PLA2G5 and PLA2G4A

Number of citations of the paper that reports this interaction (PubMedID 12124392)
0

Data Source:
HPRD (in vitro)

		PLA2G5	PLA2G4A
Description		phospholipase A2 group V	phospholipase A2 group IVA
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endosome Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Early Phagosome Phagolysosome Phagocytic Vesicle Recycling Endosome	Golgi Membrane Nucleus Nuclear Envelope Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity Calcium-independent Phospholipase A2 Activity	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Lipid Binding O-acyltransferase Activity Phosphatidylinositol-5-phosphate Binding Hydrolase Activity Phosphatidylinositol-3-phosphate Binding Metal Ion Binding Calcium-dependent Phospholipase A2 Activity Calcium-independent Phospholipase A2 Activity Carboxylic Ester Hydrolase Activity Phosphatidylinositol-4-phosphate Binding Ceramide 1-phosphate Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Phospholipid Metabolic Process Phagocytosis Phospholipid Catabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Leukotriene Biosynthetic Process Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Negative Regulation Of T Cell Proliferation Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Arachidonate Secretion Positive Regulation Of Phagocytosis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Phagosome-lysosome Fusion Positive Regulation Of Opsonization Positive Regulation Of Antifungal Innate Immune Response Positive Regulation Of Phagosome Maturation	Prostaglandin Biosynthetic Process Positive Regulation Of T-helper 1 Type Immune Response Glycerol Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Monoacylglycerol Biosynthetic Process Glycerophospholipid Metabolic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Prostaglandin Metabolic Process Phospholipid Catabolic Process Positive Regulation Of Platelet Activation Lipid Catabolic Process Arachidonate Metabolic Process Leukotriene Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Phosphatidylglycerol Catabolic Process Phosphatidylcholine Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Icosanoid Biosynthetic Process Glycerophospholipid Catabolic Process Arachidonate Secretion Establishment Of Localization In Cell Cellular Response To Antibiotic
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	phospho-PLA2 pathway Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA Arachidonate metabolism ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL COPI-independent Golgi-to-ER retrograde traffic
Drugs			Fluticasone propionate Procaine Quinacrine Niflumic acid Darapladib Fluticasone
Diseases
GWAS		Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471)	Blood urea nitrogen levels ( 31152163) Body size at age 10 ( 32376654) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163) Generalized epilepsy ( 22949513) Hip circumference adjusted for BMI ( 28552196) Hyperinsulinemia in less-fat diet ( 30327367) Hyperinsulinemia x saturated fatty acids interaction ( 30327367) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798) Non-del(5q) myelodysplastic syndromes ( 31738830) Uterine fibroid size (maximum volume) ( 30196971) Zinc levels ( 26025379)
Interacting Genes		1 interacting genes: PLA2G4A	24 interacting genes: ANXA2 BORCS6 CAP1 CASP1 CASP3 CASP4 ITGA2B ITGB3 JAK1 KAT5 MAPK1 MAPK14 MAPKAPK5 MKNK1 NCF1 PLA2G5 PRKCA RELA RPS6KA5 SHBG SIRT2 UBXN1 VIM XAGE1B
Entrez ID		5322	5321
HPRD ID		03117	08986
Ensembl ID		ENSG00000127472	ENSG00000116711
Uniprot IDs		P39877	B4DZI4 P47712
PDB IDs			1BCI 1CJY 1RLW
Enriched GO Terms of Interacting Partners?		UDP-glucose 4-epimerase Activity UDP-N-acetylglucosamine 4-epimerase Activity Organophosphate Catabolic Process Phosphatidylglycerol Catabolic Process Galactose Metabolic Process Galactose Catabolic Process Carbohydrate Metabolic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway Platelet Activating Factor Metabolic Process Cellular Response To Antibiotic Calcium-independent Phospholipase A2 Activity Calcium-dependent Phospholipase A2 Activity Positive Regulation Of Platelet Activation Ether Lipid Biosynthetic Process Phosphatidylcholine Acyl-chain Remodeling Phosphatidylcholine Catabolic Process Ceramide 1-phosphate Binding Glycerol Metabolic Process Positive Regulation Of Prostaglandin Secretion Monoacylglycerol Biosynthetic Process Platelet Activating Factor Biosynthetic Process Negative Regulation Of Multicellular Organism Growth Regulation Of Store-operated Calcium Entry Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Phosphatidylinositol-5-phosphate Binding O-acyltransferase Activity Positive Regulation Of Fatty Acid Transport Positive Regulation Of Icosanoid Secretion Arachidonate Secretion Ether Lipid Metabolic Process Glycerophospholipid Catabolic Process Phosphatidylcholine Lysophospholipase Activity Positive Regulation Of T-helper 1 Type Immune Response Leukotriene Biosynthetic Process Decidualization Regulation Of Hormone Biosynthetic Process Phospholipase Activity Protein Homodimerization Activity Leukotriene Metabolic Process Phospholipase A2 Activity Positive Regulation Of Macrophage Activation Phosphatidylinositol-4-phosphate Binding Phosphatidylglycerol Metabolic Process Response To Vitamin D Regulation Of Fatty Acid Transport Prostaglandin Metabolic Process Prostanoid Metabolic Process Response To Antibiotic Carboxylic Ester Hydrolase Activity	Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Defense Response Interleukin-18-mediated Signaling Pathway Response To Peptide Response To External Biotic Stimulus Response To Lipid Pyroptotic Inflammatory Response Response To Cytokine Protein Metabolic Process Regulation Of Inflammatory Response Regulation Of Protein Metabolic Process Positive Regulation Of Defense Response Response To Lipopolysaccharide Regulation Of Immune System Process Response To Muramyl Dipeptide Protein Kinase Activity Regulation Of Cell-cell Adhesion Response To Molecule Of Bacterial Origin Regulation Of Multicellular Organismal Process Interleukin-1-mediated Signaling Pathway Response To Mechanical Stimulus Inflammatory Response Protein Serine Kinase Activity Integrin AlphaIIb-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Protein Phosphorylation Regulation Of Cell Adhesion Phagolysosome Phosphorylation Canonical Inflammasome Complex Assembly Protein Serine/threonine Kinase Activity Negative Regulation Of Multicellular Organismal Process Protein Catabolic Process Cellular Response To Oxygen-containing Compound Kinase Activity Apoptotic Process Cellular Response To Cytokine Stimulus Focal Adhesion Negative Regulation Of Protein Catabolic Process Response To Tumor Necrosis Factor Programmed Cell Death Cell Death NLRP1 Inflammasome Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Calcium-dependent Protein Serine/threonine Kinase Activity Response To Nicotine Protein Modification Process Cellular Response To Lipid Stress-induced Premature Senescence
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