PLA2G5

Description		phospholipase A2 group V
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endosome Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Early Phagosome Phagolysosome Phagocytic Vesicle Recycling Endosome
	Molecular Function	Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity Calcium-independent Phospholipase A2 Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Phospholipid Metabolic Process Phagocytosis Phospholipid Catabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Leukotriene Biosynthetic Process Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Negative Regulation Of T Cell Proliferation Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Arachidonate Secretion Positive Regulation Of Phagocytosis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Phagosome-lysosome Fusion Positive Regulation Of Opsonization Positive Regulation Of Antifungal Innate Immune Response Positive Regulation Of Phagosome Maturation
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs
Diseases
GWAS		Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471)
Novel Interacting Genes		2 novel interacting genes: GALE STC2
Interacting Genes		1 interacting genes: PLA2G4A
Entrez ID		5322
HPRD ID		03117
Ensembl ID		ENSG00000127472
Uniprot IDs		P39877
PDB IDs
Enriched GO Terms of Interacting Partners?		UDP-glucose 4-epimerase Activity UDP-N-acetylglucosamine 4-epimerase Activity Organophosphate Catabolic Process Phosphatidylglycerol Catabolic Process Galactose Metabolic Process Galactose Catabolic Process Carbohydrate Metabolic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway Platelet Activating Factor Metabolic Process Cellular Response To Antibiotic Calcium-independent Phospholipase A2 Activity Calcium-dependent Phospholipase A2 Activity Positive Regulation Of Platelet Activation Ether Lipid Biosynthetic Process Phosphatidylcholine Acyl-chain Remodeling Phosphatidylcholine Catabolic Process Ceramide 1-phosphate Binding Glycerol Metabolic Process Positive Regulation Of Prostaglandin Secretion Monoacylglycerol Biosynthetic Process Platelet Activating Factor Biosynthetic Process Negative Regulation Of Multicellular Organism Growth Regulation Of Store-operated Calcium Entry Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Phosphatidylinositol-5-phosphate Binding O-acyltransferase Activity Positive Regulation Of Fatty Acid Transport Positive Regulation Of Icosanoid Secretion Arachidonate Secretion Ether Lipid Metabolic Process Glycerophospholipid Catabolic Process Phosphatidylcholine Lysophospholipase Activity Positive Regulation Of T-helper 1 Type Immune Response Leukotriene Biosynthetic Process Decidualization Regulation Of Hormone Biosynthetic Process Phospholipase Activity Protein Homodimerization Activity Leukotriene Metabolic Process Phospholipase A2 Activity Positive Regulation Of Macrophage Activation Phosphatidylinositol-4-phosphate Binding Phosphatidylglycerol Metabolic Process Response To Vitamin D Regulation Of Fatty Acid Transport Prostaglandin Metabolic Process Prostanoid Metabolic Process Response To Antibiotic Carboxylic Ester Hydrolase Activity
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