SIRT2 and KAT2A

Number of citations of the paper that reports this interaction (PubMedID 12887892)
0

Data Source:
HPRD (in vivo)

		SIRT2	KAT2A
Description		sirtuin 2	lysine acetyltransferase 2A
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Heterochromatin Nucleus Chromatin Silencing Complex Chromosome Nucleolus Cytoplasm Mitochondrion Centrosome Centriole Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Membrane Growth Cone Midbody Paranodal Junction Paranode Region Of Axon Cell Projection Perikaryon Myelin Sheath Lateral Loop Schmidt-Lanterman Incisure Juxtaparanode Region Of Axon Perinuclear Region Of Cytoplasm Mitotic Spindle Meiotic Spindle Glial Cell Projection	Histone Acetyltransferase Complex SAGA Complex Chromatin Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Transcription Factor TFTC Complex Oxoglutarate Dehydrogenase Complex Mitotic Spindle ATAC Complex
	Molecular Function	Chromatin Binding NAD+ Poly-ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Transferase Activity Histone Deacetylase Activity, NAD-dependent Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Histone Acetyltransferase Binding Histone Deacetylase Binding Tubulin Deacetylase Activity Ubiquitin Binding Metal Ion Binding Histone H4K16 Deacetylase Activity, NAD-dependent NAD Binding NAD+ Binding DNA-binding Transcription Factor Binding NAD-dependent Protein Demyristoylase Activity NAD-dependent Protein Depalmitoylase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding N-acetyltransferase Activity Histone H3 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein Phosphatase Binding Histone Deacetylase Binding Histone H3K9 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Histone Succinyltransferase Activity Peptide Glutaryltransferase Activity Histone Glutaryltransferase Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Immune System Process Chromatin Organization Protein Deacetylation Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Autophagy Mitotic Nuclear Membrane Reassembly Regulation Of Exit From Mitosis Nervous System Development Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Skeletal Muscle Satellite Cell Differentiation Lipid Catabolic Process Substantia Nigra Development Myelination In Peripheral Nervous System Cell Differentiation Heterochromatin Formation Subtelomeric Heterochromatin Formation Regulation Of Myelination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Peptidyl-lysine Deacetylation Epigenetic Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Regulation Of Phosphorylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Post-translational Protein Modification NLRP3 Inflammasome Complex Assembly Innate Immune Response Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Biosynthetic Process Negative Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Cell Division Meiotic Cell Cycle Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Caloric Restriction Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Hypoxia Cellular Response To Epinephrine Stimulus Tubulin Deacetylation Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Oocyte Maturation Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Reactive Oxygen Species Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Somitogenesis Positive Regulation Of Cytokine Production Neural Tube Closure Gluconeogenesis Regulation Of DNA Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Heart Development Long-term Memory Regulation Of Gene Expression Internal Peptidyl-lysine Acetylation Telencephalon Development Metencephalon Development Midbrain Development Positive Regulation Of Cell Projection Organization Regulation Of Protein Stability Response To Nutrient Levels Multicellular Organism Growth Protein Modification Process Regulation Of RNA Splicing Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Negative Regulation Of Centriole Replication Fibroblast Proliferation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Regulation Of T Cell Activation Regulation Of Cell Division Regulation Of Cell Cycle Limb Development Regulation Of Cartilage Development Regulation Of Small Molecule Metabolic Process Cellular Response To Tumor Necrosis Factor Peptidyl-lysine Glutarylation Regulation Of Bone Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Stem Cell Population Maintenance Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Initiation of Nuclear Envelope (NE) Reformation	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Ub-specific processing proteases RNA Polymerase I Transcription Initiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis Formation of WDR5-containing histone-modifying complexes Formation of paraxial mesoderm
Drugs		Cambinol	Coenzyme A
Diseases
GWAS			Coronary artery disease ( 29212778 33020668) Inflammatory bowel disease ( 26278503) Mean reticulocyte volume ( 32888494) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)
Interacting Genes		23 interacting genes: ARHGDIA ATRIP CDC14B CDC20 CDK2 EP300 FZR1 H3C1 HDAC6 HIF1A HOXA10 KAT2A KAT2B MCL1 MDM2 MORC2 OXTR PHGDH PLA2G4A RAD51 SP140 TUBA4A XPO1	67 interacting genes: AKT1 ATXN7 BATF2 BECN1 CCND2 CCNE1 CDK2 CDK6 CDKN2B CEBPA CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL ECHS1 EID1 EP300 FZR1 GATA2 GRM1 H1-5 H2AC20 H2AC4 H2BC21 H2BC3 H3-4 H3C1 H3C14 H4C14 H4C16 H4C7 HSD11B2 IRF1 IRF2 IRF7 KDELR2 LATS2 MAP2K3 MAPK14 MYB MYC NF2 NOTCH1 PBX1 PRKDC PYGO2 RASSF1 RBPJ RELA RPA1 SIRT2 SNCA STK11 TACC1 TACC2 TACC3 TADA2A TCF3 TP53 TRRAP TSC1 TTYH2 UBE2I XRCC6
Entrez ID		22933	2648
HPRD ID		10377	03807
Ensembl ID		ENSG00000068903	ENSG00000108773
Uniprot IDs		A0A0A0MRF5 Q8IXJ6	Q92830
PDB IDs		1J8F 3ZGO 3ZGV 4L3O 4R8M 4RMG 4RMH 4RMI 4RMJ 4X3O 4X3P 4Y6L 4Y6O 4Y6Q 5D7O 5D7P 5D7Q 5DY4 5DY5 5FYQ 5G4C 5MAR 5MAT 5Y0Z 5Y5N 5YQL 5YQM 5YQN 5YQO 6L65 6L66 6L71 6L72 6NR0 6QCN 7BOS 7BOT 8OWZ 8PY3 8QOO 8QT0 8QT1 8QT2 8QT3 8QT4 8QT8 8QTU 8TGP 8XE7	1F68 1Z4R 3D7C 5H84 5H86 5MLJ 5TRL 5TRM 6J3P 8E6O 8H65 8H66 8H6C 8H6D
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Process Histone Deacetylase Binding Negative Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Cellular Response To Stress Negative Regulation Of Cell Cycle Internal Protein Amino Acid Acetylation Nucleoplasm Protein-containing Complex Regulation Of Metabolic Process DNA Damage Response Regulation Of Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Peptidyl-lysine Acetylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Histone H3K9 Acetyltransferase Activity Acetyltransferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Histone Acetyltransferase Complex Regulation Of Cellular Response To Stress Protein-lysine-acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis DNA Damage Checkpoint Signaling Histone Acetyltransferase Activity Nucleus Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cell Cycle Phase Transition Protein Acetylation Chromatin Remodeling Small Molecule Biosynthetic Process L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Monocarboxylic Acid Metabolic Process Epigenetic Regulation Of Gene Expression Cytosol Negative Regulation Of Centriole Replication Regulation Of Centrosome Duplication Intracellular Signal Transduction Response To Stress Gluconeogenesis Regulation Of Gluconeogenesis	Nucleus Nucleoplasm Regulation Of Cell Cycle Regulation Of Cell Population Proliferation Structural Constituent Of Chromatin Nucleosome Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Development Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Chromatin Organization Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Process Chromatin Binding Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Protein Heterodimerization Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Hemopoiesis DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Leukocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Development Mitotic Cell Cycle Phase Transition Mononuclear Cell Differentiation Nucleosome Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Cell Cycle Phase Transition Chromosome
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