SIRT2 and RAD51

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		SIRT2	RAD51
Description		sirtuin 2	RAD51 recombinase
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Heterochromatin Nucleus Chromatin Silencing Complex Chromosome Nucleolus Cytoplasm Mitochondrion Centrosome Centriole Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Membrane Growth Cone Midbody Paranodal Junction Paranode Region Of Axon Cell Projection Perikaryon Myelin Sheath Lateral Loop Schmidt-Lanterman Incisure Juxtaparanode Region Of Axon Perinuclear Region Of Cytoplasm Mitotic Spindle Meiotic Spindle Glial Cell Projection	Nuclear Ubiquitin Ligase Complex Nuclear Chromosome Chromosome, Telomeric Region Chromatin Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Centrosome Cytosol Cytoskeleton PML Body Protein-containing Complex Site Of Double-strand Break Perinuclear Region Of Cytoplasm Presynaptic Intermediate Filament Cytoskeleton
	Molecular Function	Chromatin Binding NAD+ Poly-ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Transferase Activity Histone Deacetylase Activity, NAD-dependent Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Histone Acetyltransferase Binding Histone Deacetylase Binding Tubulin Deacetylase Activity Ubiquitin Binding Metal Ion Binding Histone H4K16 Deacetylase Activity, NAD-dependent NAD Binding NAD+ Binding DNA-binding Transcription Factor Binding NAD-dependent Protein Demyristoylase Activity NAD-dependent Protein Depalmitoylase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	DNA Strand Exchange Activity Nucleotide Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Single-stranded DNA Helicase Activity Enzyme Binding Identical Protein Binding DNA Polymerase Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Immune System Process Chromatin Organization Protein Deacetylation Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Autophagy Mitotic Nuclear Membrane Reassembly Regulation Of Exit From Mitosis Nervous System Development Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Skeletal Muscle Satellite Cell Differentiation Lipid Catabolic Process Substantia Nigra Development Myelination In Peripheral Nervous System Cell Differentiation Heterochromatin Formation Subtelomeric Heterochromatin Formation Regulation Of Myelination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Peptidyl-lysine Deacetylation Epigenetic Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Regulation Of Phosphorylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Post-translational Protein Modification NLRP3 Inflammasome Complex Assembly Innate Immune Response Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Biosynthetic Process Negative Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Cell Division Meiotic Cell Cycle Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Caloric Restriction Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Hypoxia Cellular Response To Epinephrine Stimulus Tubulin Deacetylation Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Oocyte Maturation Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Reactive Oxygen Species Metabolic Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Metabolic Process DNA Repair DNA Recombination Mitotic Recombination DNA Damage Response Meiosis I Reciprocal Meiotic Recombination Response To Xenobiotic Stimulus Response To Toxic Substance Response To X-ray Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Replication Fork Processing Telomere Organization Interstrand Cross-link Repair DNA Strand Invasion Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Cellular Response To Alkaloid Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Camptothecin Response To Glucoside Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic Recombination-dependent Replication Fork Processing Double-strand Break Repair Involved In Meiotic Recombination Regulation Of DNA Damage Checkpoint
Pathways		Initiation of Nuclear Envelope (NE) Reformation	HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs		Cambinol	Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib
Diseases
GWAS			Anxiety and stress-related disorders ( 31116379) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)
Interacting Genes		23 interacting genes: ARHGDIA ATRIP CDC14B CDC20 CDK2 EP300 FZR1 H3C1 HDAC6 HIF1A HOXA10 KAT2A KAT2B MCL1 MDM2 MORC2 OXTR PHGDH PLA2G4A RAD51 SP140 TUBA4A XPO1	99 interacting genes: ABL1 AGO2 ATM ATRX BARD1 BCCIP BCR BLM BRCA1 BRCA2 CASP3 CASP7 CASP8AP2 CCND1 CDH13 CHD3 CHEK1 CRYAA CSNK2A1 CSNK2B CST6 CTCF DDB2 DMC1 DNAJA3 ENAH EP400 ERCC2 ERCC5 EVL FANCD2 FANCI FBH1 FBXO5 FIRRM GMEB1 HID1 HNRNPC HSP90AA1 IL24 IRS1 ITIH5 MAPK8IP3 MCPH1 MDC1 MMS22L MSH4 NBN NCL NELFB NXF1 PARPBP PCSK1N PDS5B PFN1 PIAS1 PLK1 POLA1 RAD18 RAD51AP1 RAD51AP2 RAD51C RAD52 RAD54B RAD54L RAD54L2 RECQL5 RELA RFWD3 RNF20 RPA1 RPA2 RPA3 SEM1 SFR1 SIRT2 ST14 SUMO1 SUMO2 SWSAP1 TDG TFF1 TOPORS TP53 TP53BP1 UBE2I UCHL3 UGDH UHRF2 UMPS USP10 VASP VIM WDR48 WRN XPO1 XRCC2 XRCC3 ZDHHC17
Entrez ID		22933	5888
HPRD ID		10377	01557
Ensembl ID		ENSG00000068903	ENSG00000051180
Uniprot IDs		A0A0A0MRF5 Q8IXJ6	Q06609
PDB IDs		1J8F 3ZGO 3ZGV 4L3O 4R8M 4RMG 4RMH 4RMI 4RMJ 4X3O 4X3P 4Y6L 4Y6O 4Y6Q 5D7O 5D7P 5D7Q 5DY4 5DY5 5FYQ 5G4C 5MAR 5MAT 5Y0Z 5Y5N 5YQL 5YQM 5YQN 5YQO 6L65 6L66 6L71 6L72 6NR0 6QCN 7BOS 7BOT 8OWZ 8PY3 8QOO 8QT0 8QT1 8QT2 8QT3 8QT4 8QT8 8QTU 8TGP 8XE7	1B22 1N0W 5H1B 5H1C 5JZC 5NP7 5NWL 7C9A 7EJC 7EJE 8BQ2 8BR2 8BSC 8GYK 8JND 8JNE 8JNF 8PBC 8PBD 8R64 8RCD 8RCF 8XBT 8XBU 8XBV 8XBW 8XBX 8XBY
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Process Histone Deacetylase Binding Negative Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Cellular Response To Stress Negative Regulation Of Cell Cycle Internal Protein Amino Acid Acetylation Nucleoplasm Protein-containing Complex Regulation Of Metabolic Process DNA Damage Response Regulation Of Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Peptidyl-lysine Acetylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Histone H3K9 Acetyltransferase Activity Acetyltransferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Histone Acetyltransferase Complex Regulation Of Cellular Response To Stress Protein-lysine-acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis DNA Damage Checkpoint Signaling Histone Acetyltransferase Activity Nucleus Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cell Cycle Phase Transition Protein Acetylation Chromatin Remodeling Small Molecule Biosynthetic Process L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Monocarboxylic Acid Metabolic Process Epigenetic Regulation Of Gene Expression Cytosol Negative Regulation Of Centriole Replication Regulation Of Centrosome Duplication Intracellular Signal Transduction Response To Stress Gluconeogenesis Regulation Of Gluconeogenesis	DNA Repair DNA Damage Response DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Recombinational Repair Cellular Response To Stress DNA Recombination Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stress Macromolecule Metabolic Process Nucleus PML Body Signal Transduction In Response To DNA Damage Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process Regulation Of DNA Recombination Replication Fork Regulation Of Cell Cycle Single-stranded DNA Binding Response To Ionizing Radiation DNA Binding DNA Damage Checkpoint Signaling Response To Radiation Regulation Of DNA Repair Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Chromosome Organization Mitotic DNA Integrity Checkpoint Signaling Chromosome Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Damaged DNA Binding Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Cell Cycle Process Site Of Double-strand Break Homologous Recombination Negative Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Chromosome, Telomeric Region Response To X-ray Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Negative Regulation Of DNA Recombination
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