ITPR2 and TRPC1

Number of citations of the paper that reports this interaction (PMID 10970773)
23

Data Source:
HPRD (in vitro, in vivo)

		ITPR2	TRPC1
Gene Name		inositol 1,4,5-trisphosphate receptor, type 2	transient receptor potential cation channel, subfamily C, member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Cell Cortex Membrane Integral Component Of Membrane Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Sarcomere Costamere Receptor Complex Membrane Raft
	Molecular Function	Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Transmembrane Transporter Activity Phosphatidylinositol Binding	Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Ion Channel Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Response To Hypoxia Energy Reserve Metabolic Process Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Calcium Ion Transmembrane Transport Cellular Response To CAMP Cellular Response To Ethanol	Calcium Ion Transport Axon Guidance Ion Transmembrane Transport Saliva Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cytosolic Calcium Ion Homeostasis Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization	Signaling by the B Cell Receptor (BCR) Ion channel transport Axon guidance Role of second messengers in netrin-1 signaling TRP channels Stimuli-sensing channels Netrin-1 signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 17827064) Renal cell carcinoma ( 22010048) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		4 interactors: BANK1 PRKACA TRPC1 TRPC4	14 interactors: BMPR2 CAV1 GRIA1 HOMER1 HOMER3 ITPR2 ITPR3 MDFI MX1 PKD2 RHOA TRPC3 TRPC4 TRPC5
Entrez ID		3709	7220
HPRD ID		02536	11894
Ensembl ID		ENSG00000123104	ENSG00000144935
Uniprot IDs		Q14571	P48995
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Chemotaxis Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Ion Homeostasis Histone H3-T6 Phosphorylation Regulation Of Cellular Localization Cytosolic Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport Locomotion Positive Regulation Of Intracellular Transport Gamma-aminobutyric Acid Secretion Cellular Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Calcium Ion Homeostasis Calcium Ion Transport Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Secretion Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Desmosome Assembly Gamma-aminobutyric Acid Transport Negative Regulation Of Glial Cell Apoptotic Process Saliva Secretion Transmembrane Transport Axon Guidance Regulation Of Protein Secretion Negative Regulation Of Transport Regulation Of Tight Junction Assembly Cell Development Cellular Metal Ion Homeostasis Response To External Stimulus Negative Regulation Of Glucose Import Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macrophage Differentiation Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Intracellular Transport Cellular Cation Homeostasis Positive Regulation Of MAPK Cascade Response To Parathyroid Hormone Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Cellular Ion Homeostasis Positive Regulation Of Protein Export From Nucleus Regulation Of Cell Activation Metal Ion Homeostasis Cell Communication By Electrical Coupling Activation Of Protein Kinase A Activity	Vascular Endothelial Growth Factor Receptor Signaling Pathway Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transport Metal Ion Transport Positive Regulation Of Calcium Ion Transport Response To Stimulus Response To Calcium Ion Regulation Of Cellular Localization Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cation Transport Ion Transport Cell Communication Response To External Stimulus Blood Coagulation Hemostasis Regulation Of Intracellular Transport Ion Transmembrane Transport Platelet Activation Positive Regulation Of Ion Transport Response To Inorganic Substance Glutamate Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cation Transmembrane Transport Cellular Response To Stimulus Regulation Of Signaling Regulation Of Cation Channel Activity Regulation Of Body Fluid Levels Regulation Of Endothelial Cell Proliferation Wound Healing Regulation Of Transcription Factor Import Into Nucleus Anatomical Structure Morphogenesis Regulation Of Ion Transport Regulation Of Protein Transport Transmembrane Transport Response To Organic Substance Response To Stress Regulation Of Establishment Of Protein Localization Response To Metal Ion Response To Wounding Intracellular Signal Transduction Positive Regulation Of Transport Positive Regulation Of Signal Transduction Inositol Phosphate-mediated Signaling Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Axon Guidance
Tagcloud ?		accumulation besides calcium channels enable endoplasmic escape inositol ip3r2 mcu mediate mitochondria mitochondrial ois oncogene pathophysiological regulators release replicative restricted reticulum retinoblastoma screen senescence subsequent triggers triphosphate trisphosphate uniporter	ca2 cation cdna channels converted dami details entry excitable hel homologues htrp1 identity influx meg01 megakaryocytes megakaryocytic platelets primers producers revealing sizes splicing store trpc2 trpl
Tagcloud (Difference) ?		accumulation besides calcium enable endoplasmic escape inositol ip3r2 mcu mediate mitochondria mitochondrial ois oncogene pathophysiological regulators release replicative restricted reticulum retinoblastoma screen senescence subsequent triggers triphosphate trisphosphate uniporter	ca2 cation cdna converted dami details entry excitable hel homologues htrp1 identity influx meg01 megakaryocytes megakaryocytic platelets primers producers revealing sizes splicing store trpc2 trpl
Tagcloud (Intersection) ?		channels