ITPR2 and TRPC4

Number of citations of the paper that reports this interaction (PMID 11163362)
8

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ITPR2	TRPC4
Gene Name		inositol 1,4,5-trisphosphate receptor, type 2	transient receptor potential cation channel, subfamily C, member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Cell Cortex Membrane Integral Component Of Membrane Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Receptor Complex	Plasma Membrane Caveola Cell-cell Junction Cell Surface Basolateral Plasma Membrane Cortical Cytoskeleton Calcium Channel Complex
	Molecular Function	Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Transmembrane Transporter Activity Phosphatidylinositol Binding	Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Response To Hypoxia Energy Reserve Metabolic Process Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Calcium Ion Transmembrane Transport Cellular Response To CAMP Cellular Response To Ethanol	Calcium Ion Transport Axon Guidance Gamma-aminobutyric Acid Secretion Ion Transmembrane Transport Oligodendrocyte Differentiation Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization	Ion channel transport Axon guidance Role of second messengers in netrin-1 signaling TRP channels Stimuli-sensing channels Netrin-1 signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 17827064) Renal cell carcinoma ( 22010048) Waist-hip ratio ( 20935629)	Age-related macular degeneration ( 23326517) Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: BANK1 PRKACA TRPC1 TRPC4	9 interactors: ITCH ITPR1 ITPR2 ITPR3 MX1 SLC9A3R1 TJP1 TRPC1 TRPC5
Entrez ID		3709	7223
HPRD ID		02536	09154
Ensembl ID		ENSG00000123104	ENSG00000133107
Uniprot IDs		Q14571	Q3KR50 Q9UBN4
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Chemotaxis Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Ion Homeostasis Histone H3-T6 Phosphorylation Regulation Of Cellular Localization Cytosolic Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport Locomotion Positive Regulation Of Intracellular Transport Gamma-aminobutyric Acid Secretion Cellular Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Calcium Ion Homeostasis Calcium Ion Transport Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Secretion Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Desmosome Assembly Gamma-aminobutyric Acid Transport Negative Regulation Of Glial Cell Apoptotic Process Saliva Secretion Transmembrane Transport Axon Guidance Regulation Of Protein Secretion Negative Regulation Of Transport Regulation Of Tight Junction Assembly Cell Development Cellular Metal Ion Homeostasis Response To External Stimulus Negative Regulation Of Glucose Import Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macrophage Differentiation Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Intracellular Transport Cellular Cation Homeostasis Positive Regulation Of MAPK Cascade Response To Parathyroid Hormone Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Cellular Ion Homeostasis Positive Regulation Of Protein Export From Nucleus Regulation Of Cell Activation Metal Ion Homeostasis Cell Communication By Electrical Coupling Activation Of Protein Kinase A Activity	Calcium Ion Transmembrane Transport Inositol Phosphate-mediated Signaling Calcium Ion Transport Metal Ion Transport Cellular Chemical Homeostasis Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Cation Transport Cellular Homeostasis Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemical Homeostasis Cation Transmembrane Transport Ion Transport Cellular Ion Homeostasis Energy Reserve Metabolic Process Immune Response-regulating Signaling Pathway Second-messenger-mediated Signaling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Ion Homeostasis Cytosolic Calcium Ion Homeostasis Regulation Of Body Fluid Levels Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Immune Response Ion Transmembrane Transport Neurotrophin TRK Receptor Signaling Pathway Defense Response Positive Regulation Of Immune Response Regulation Of Secretion Regulation Of Peptide Hormone Secretion Neurotrophin Signaling Pathway Homeostatic Process Fc-epsilon Receptor Signaling Pathway Response To Stimulus Phagocytosis Regulation Of Hormone Secretion Fc Receptor Signaling Pathway Calcium Ion Transport Into Cytosol Immune Response-activating Cell Surface Receptor Signaling Pathway
Tagcloud ?		accumulation besides calcium channels enable endoplasmic escape inositol ip3r2 mcu mediate mitochondria mitochondrial ois oncogene pathophysiological regulators release replicative restricted reticulum retinoblastoma screen senescence subsequent triggers triphosphate trisphosphate uniporter	analyse anatomically convey drg drgs fibres ganglia ganglion refined somatosensation string trigeminal trpa1 trpc1 trpc3 trpc5 trpm3 trpm4 trpm5 trpm6 trpm7 trpm8 trpml1 trpp2 trpv1 trpv2 trpv4 vertebral
Tagcloud (Difference) ?		accumulation besides calcium channels enable endoplasmic escape inositol ip3r2 mcu mediate mitochondria mitochondrial ois oncogene pathophysiological regulators release replicative restricted reticulum retinoblastoma screen senescence subsequent triggers triphosphate trisphosphate uniporter	analyse anatomically convey drg drgs fibres ganglia ganglion refined somatosensation string trigeminal trpa1 trpc1 trpc3 trpc5 trpm3 trpm4 trpm5 trpm6 trpm7 trpm8 trpml1 trpp2 trpv1 trpv2 trpv4 vertebral
Tagcloud (Intersection) ?