ITPR2

Gene Name		inositol 1,4,5-trisphosphate receptor, type 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Cell Cortex Membrane Integral Component Of Membrane Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Receptor Complex
	Molecular Function	Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Transmembrane Transporter Activity Phosphatidylinositol Binding
	Biological Process	Response To Hypoxia Energy Reserve Metabolic Process Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Calcium Ion Transmembrane Transport Cellular Response To CAMP Cellular Response To Ethanol
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 17827064) Renal cell carcinoma ( 22010048) Waist-hip ratio ( 20935629)
Protein-protein Interactions		4 interactors: BANK1 PRKACA TRPC1 TRPC4
Entrez ID		3709
HPRD ID		02536
Ensembl ID		ENSG00000123104
Uniprot IDs		Q14571
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Chemotaxis Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Ion Homeostasis Histone H3-T6 Phosphorylation Regulation Of Cellular Localization Cytosolic Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport Locomotion Positive Regulation Of Intracellular Transport Gamma-aminobutyric Acid Secretion Cellular Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Calcium Ion Homeostasis Calcium Ion Transport Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Secretion Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Desmosome Assembly Gamma-aminobutyric Acid Transport Negative Regulation Of Glial Cell Apoptotic Process Saliva Secretion Transmembrane Transport Axon Guidance Regulation Of Protein Secretion Negative Regulation Of Transport Regulation Of Tight Junction Assembly Cell Development Cellular Metal Ion Homeostasis Response To External Stimulus Negative Regulation Of Glucose Import Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macrophage Differentiation Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Intracellular Transport Cellular Cation Homeostasis Positive Regulation Of MAPK Cascade Response To Parathyroid Hormone Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Cellular Ion Homeostasis Positive Regulation Of Protein Export From Nucleus Regulation Of Cell Activation Metal Ion Homeostasis Cell Communication By Electrical Coupling Activation Of Protein Kinase A Activity
Tagcloud ?		accumulation besides calcium channels enable endoplasmic escape inositol ip3r2 mcu mediate mitochondria mitochondrial ois oncogene pathophysiological regulators release replicative restricted reticulum retinoblastoma screen senescence subsequent triggers triphosphate trisphosphate uniporter