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PKD2 and PLSCR1
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
PKD2
PLSCR1
Description
polycystin 2, transient receptor potential cation channel
phospholipid scramblase 1
Image
GO Annotations
Cellular Component
Polycystin Complex
Extracellular Region
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Cell-cell Junction
Cilium
Basal Plasma Membrane
Membrane
Basolateral Plasma Membrane
Lamellipodium
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Motile Cilium
Vesicle
Monoatomic Ion Channel Complex
Cation Channel Complex
Ciliary Basal Body
Cell Projection
Basal Cortex
Ciliary Membrane
Extracellular Exosome
Mitotic Spindle
Non-motile Cilium
Lumenal Side Of Endoplasmic Reticulum Membrane
Cytoplasmic Side Of Endoplasmic Reticulum Membrane
Migrasome
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Membrane
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Signaling Receptor Binding
Voltage-gated Monoatomic Ion Channel Activity
Voltage-gated Calcium Channel Activity
Voltage-gated Sodium Channel Activity
Voltage-gated Potassium Channel Activity
Monoatomic Cation Channel Activity
Calcium Channel Activity
Potassium Channel Activity
Sodium Channel Activity
Calcium Ion Binding
Protein Binding
Cytoskeletal Protein Binding
Channel Activity
Outward Rectifier Potassium Channel Activity
Voltage-gated Monoatomic Cation Channel Activity
Identical Protein Binding
Protein Homodimerization Activity
Actinin Binding
HLH Domain Binding
Transmembrane Transporter Binding
Metal Ion Binding
Calcium-induced Calcium Release Activity
ATPase Binding
Phosphoprotein Binding
Muscle Alpha-actinin Binding
Transcription Regulator Inhibitor Activity
Magnesium Ion Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Virus Receptor Activity
DNA Binding
Nuclease Activity
Epidermal Growth Factor Receptor Binding
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
Hydrolase Activity
SH3 Domain Binding
Phospholipid Scramblase Activity
Enzyme Binding
Lead Ion Binding
CD4 Receptor Binding
Mercury Ion Binding
Biological Process
Branching Involved In Ureteric Bud Morphogenesis
Kidney Development
Liver Development
Embryonic Placenta Development
Heart Looping
Detection Of Nodal Flow
Monoatomic Ion Transport
Potassium Ion Transport
Sodium Ion Transport
Calcium Ion Transport
Intracellular Calcium Ion Homeostasis
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Determination Of Left/right Symmetry
Heart Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Wnt Signaling Pathway
Calcium-mediated Signaling
Spinal Cord Development
Neural Tube Development
Monoatomic Ion Transmembrane Transport
Cellular Response To Reactive Oxygen Species
Metanephric Part Of Ureteric Bud Development
Sodium Ion Transmembrane Transport
Aorta Development
Regulation Of Cell Population Proliferation
Chordate Embryonic Development
Cilium Organization
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Organ Development
Detection Of Mechanical Stimulus
Release Of Sequestered Calcium Ion Into Cytosol
Protein Tetramerization
Protein Homotetramerization
Protein Heterotetramerization
Centrosome Duplication
Establishment Of Localization In Cell
Regulation Of Cell Cycle
Placenta Blood Vessel Development
Renal Tubule Morphogenesis
Renal Artery Morphogenesis
Calcium Ion Transmembrane Transport
Cellular Response To Calcium Ion
Cellular Response To CAMP
Cellular Response To Hydrostatic Pressure
Cellular Response To Osmotic Stress
Cellular Response To Fluid Shear Stress
Potassium Ion Transmembrane Transport
Determination Of Liver Left/right Asymmetry
Metanephric Mesenchyme Development
Mesonephric Tubule Development
Mesonephric Duct Development
Metanephric Smooth Muscle Tissue Development
Metanephric Cortex Development
Metanephric Ascending Thin Limb Development
Metanephric Cortical Collecting Duct Development
Metanephric Distal Tubule Development
Metanephric S-shaped Body Morphogenesis
Regulation Of Calcium Ion Import
Inorganic Cation Transmembrane Transport
Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Phosphatidylserine Biosynthetic Process
Lipid Transport
Apoptotic Process
Acute-phase Response
Response To Lead Ion
Positive Regulation Of Gene Expression
Plasma Membrane Phospholipid Scrambling
Platelet Activation
Regulation Of Mast Cell Activation
Response To Interferon-beta
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Symbiont Entry Into Host Cell
Negative Regulation Of Phagocytosis
Defense Response To Virus
Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Phosphatidylserine Exposure On Apoptotic Cell Surface
Positive Regulation Of Chromosome Separation
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways
VxPx cargo-targeting to cilium
VxPx cargo-targeting to cilium
Drugs
Diseases
Polycystic kidney disease
GWAS
Coffee consumption (cups per day) (
25288136
)
Dental caries (
23064961
)
Gout (
30899057
)
Hyperuricemia (
28776340
)
Serum alkaline phosphatase levels (
33547301
)
Serum uric acid levels in response to allopurinol in gout (
25676789
)
Uric acid levels (
29558500
)
Gut microbiota (beta diversity) (
27723756
)
Interacting Genes
21 interacting genes:
ACTN2
CD2AP
CYSRT1
DIAPH1
HAX1
HSF2BP
KRT40
KRTAP10-3
KRTAP10-8
KRTAP6-2
LMNA
MAGEA8
MDFI
PACS1
PACS2
PKD1
PLSCR1
PTPRG
TNNI3
TPM1
TRPC1
132 interacting genes:
ABL1
ADAMTSL4
ADCY7
ANXA11
APP
ARNT2
ATG12
ATN1
BACE1
BCL6B
C10orf62
CATSPER1
CCDC33
CCER1
CDC42EP1
CHRD
CNTFR
CPSF6
CRK
CRKL
CRY1
CTBP1-DT
CTSZ
DAZAP2
DDIAS
DEF6
DEPP1
DHRS1
DLK2
DMRT3
DOCK2
DTX2
EFEMP2
EGFR
ENKD1
EP300
ESR2
EWSR1
EXD3
FAM107A
FBLN1
FBXL18
FRAT1
FRS3
GDPD5
GLRX3
GNAI2
GPRIN2
HEY2
HOXA1
HOXA9
HOXB6
HRG
ILF3
INTS11
IP6K2
IQCN
KIF1A
KRTAP10-11
KRTAP10-3
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP5-6
KRTAP9-2
LASP1
LCE2D
LCE3C
LCE4A
LGALS9C
LINC00663
LINC01547
LONRF1
MAPK6
MDK
MED15
MGAT5B
MVP
NECAP2
NEU4
NOC4L
NPDC1
NR0B2
NTN4
OGDH
P2RY6
PCED1A
PGLS
PHLDA1
PITX1
PKD2
PLSCR3
PLSCR4
PML
PPDPF
PRKCD
PRR13
RAMAC
RASD1
RBL1
RERE
RGS3
RXRB
SCNM1
SF1
SHC1
SLC25A6
SLC35A2
SLPI
SMARCC1
SMCP
SPATA8
SPG7
SPRY2
SRC
STK16
TFG
THBS1
TRAF4
TRIM42
VASP
VPS37C
VSIR
YIPF3
ZBTB16
ZNF417
ZNF581
ZNF587
ZNF638
ZNF688
ZNF764
Entrez ID
5311
5359
HPRD ID
01437
08855
Ensembl ID
ENSG00000118762
ENSG00000188313
Uniprot IDs
Q13563
Q9UEU6
C9J7K9
O15162
PDB IDs
2KLD
2KLE
2KQ6
2Y4Q
3HRN
3HRO
5K47
5MKE
5MKF
5T4D
6A70
6D1W
6T9N
6T9O
6WB8
8HK7
8K3S
9DLI
9DWQ
1Y2A
Enriched GO Terms of Interacting Partners
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Transmembrane Transporter Binding
Intermediate Filament
Actin Filament
Sarcomere
Alcohol Dehydrogenase (NAD+) Activity
Actin Filament Binding
Striated Muscle Cell Development
Regulation Of Cytoskeleton Organization
Actin Binding
Cytosol
All-trans-retinol Dehydrogenase (NAD+) Activity
Cation Channel Complex
Actin-myosin Filament Sliding
Muscle Filament Sliding
Protein Domain Specific Binding
Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Keratin Filament
Muscle Cell Development
Structural Constituent Of Cytoskeleton
Regulation Of Muscle System Process
Positive Regulation Of Cation Transmembrane Transport
Regulation Of Monoatomic Cation Transmembrane Transport
Retinoic Acid Metabolic Process
Protein Heterooligomerization
Actin Cytoskeleton
Positive Regulation Of Monoatomic Ion Transmembrane Transport
Regulation Of Monoatomic Ion Transmembrane Transport
Regulation Of Biological Quality
Actin Filament Uncapping
Identical Protein Binding
Butanol Dehydrogenase (NAD+) Activity
Ethanol Dehydrogenase (NAD+) Activity
Actin Filament Polymerization
Regulation Of Calcium Ion Transmembrane Transport
Regulation Of System Process
S-methyl-5-thioadenosine Phosphorylase Activity
Metanephric Distal Tubule Morphogenesis
Monoatomic Cation Channel Activity
Regulation Of ATP-dependent Activity
Negative Regulation Of Angiotensin-activated Signaling Pathway
Regulation Of Cell Proliferation Involved In Kidney Morphogenesis
Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions
Positive Regulation Of Heart Rate By Epinephrine
Actin-mediated Cell Contraction
Enzyme Binding
Ephrin Receptor Binding
Protein Binding
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell-substrate Adhesion
Cellular Response To Transforming Growth Factor Beta Stimulus
Keratin Filament
Cellular Response To Growth Factor Stimulus
Regulation Of ERK1 And ERK2 Cascade
Response To Transforming Growth Factor Beta
Intermediate Filament
Response To Growth Factor
Regulation Of Cell Adhesion
Positive Regulation Of MAPK Cascade
Helper T Cell Diapedesis
Shc-EGFR Complex
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Superoxide Metabolic Process
Negative Regulation Of Long-term Synaptic Potentiation
Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Cell Adhesion
Positive Regulation Of Cell Adhesion
Response To Lipid
Hair Cycle
Apoptotic Process
Regulation Of Focal Adhesion Assembly
Regulation Of MAPK Cascade
Cerebellar Neuron Development
Regulation Of Apoptotic Process
Protein Tyrosine Kinase Activator Activity
Cellular Response To Lipid
Morphogenesis Of A Branching Structure
ERBB Signaling Pathway
Regulation Of DNA-templated Transcription
Regulation Of Cell-substrate Junction Organization
Gland Development
Regulation Of RNA Biosynthetic Process
Programmed Cell Death
Cell Death
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Non-membrane Spanning Protein Tyrosine Kinase Activity
Epidermal Growth Factor Binding
System Development
Regulation Of Cell Population Proliferation
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Cell Migration
Regulation Of Programmed Cell Death
Regulation Of Cell-matrix Adhesion
Positive Regulation Of Superoxide Anion Generation
Central Nervous System Neuron Development
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Tagcloud (Intersection)
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