PKD2 and ACTN2

Number of citations of the paper that reports this interaction (PMID 15843396)
23

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PKD2	ACTN2
Gene Name		polycystic kidney disease 2 (autosomal dominant)	actinin, alpha 2
Image
Gene Ontology Annotations	Cellular Component	Polycystin Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cilium Basal Plasma Membrane Lamellipodium Motile Primary Cilium Nonmotile Primary Cilium Filamentous Actin Ciliary Basal Body Basal Cortex Ciliary Membrane Extracellular Vesicular Exosome Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Mitotic Spindle	Extracellular Region Cytosol Cytoskeleton Actin Filament Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Voltage-gated Ion Channel Activity Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Voltage-gated Cation Channel Activity Identical Protein Binding Protein Homodimerization Activity Actinin Binding HLH Domain Binding Ion Channel Binding Calcium-induced Calcium Release Activity ATPase Binding Phosphoprotein Binding Muscle Alpha-actinin Binding	Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle LIM Domain Binding Thyroid Hormone Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Protein Dimerization Activity Actin Filament Binding FATZ Binding Titin Z Domain Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Liver Development Embryonic Placenta Development Heart Looping Detection Of Nodal Flow Calcium Ion Transport Cell Cycle Arrest JAK-STAT Cascade Determination Of Left/right Symmetry Heart Development Negative Regulation Of Cell Proliferation Spinal Cord Development Neural Tube Development Regulation Of CAMP Metabolic Process Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Reactive Oxygen Species Metanephric Part Of Ureteric Bud Development Sodium Ion Transmembrane Transport Aorta Development Regulation Of Cell Proliferation Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Detection Of Mechanical Stimulus Release Of Sequestered Calcium Ion Into Cytosol Centrosome Duplication Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Placenta Blood Vessel Development Renal Tubule Morphogenesis Renal Artery Morphogenesis Calcium Ion Transmembrane Transport Positive Regulation Of Cell Cycle Arrest Cellular Response To Hydrostatic Pressure Cellular Response To Osmotic Stress Cellular Response To Fluid Shear Stress Potassium Ion Transmembrane Transport Determination Of Liver Left/right Asymmetry Metanephric Mesenchyme Development Mesonephric Tubule Development Mesonephric Duct Development Metanephric Smooth Muscle Tissue Development Metanephric Cortex Development Metanephric Ascending Thin Limb Development Metanephric Cortical Collecting Duct Development Metanephric Distal Tubule Development Metanephric S-shaped Body Morphogenesis Regulation Of Calcium Ion Import Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Platelet Degranulation Cell Adhesion Synaptic Transmission Blood Coagulation Microspike Assembly Muscle Filament Sliding Platelet Activation Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Focal Adhesion Assembly Protein Homotetramerization Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Receptor Activity
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium	Striated Muscle Contraction Platelet degranulation CREB phosphorylation through the activation of Ras Activation of NMDA receptor upon glutamate binding and postsynaptic events Response to elevated platelet cytosolic Ca2+ CREB phosphorylation through the activation of CaMKII Nephrin interactions Platelet activation, signaling and aggregation Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS		Dental caries ( 23064961)
Protein-Protein Interactions		15 interactors: ACTN2 CD2AP DIAPH1 HAX1 KRT40 KRTAP10-3 KRTAP10-8 MAGEA8 PACS1 PACS2 PKD1 PLSCR1 TNNI3 TPM1 TRPC1	59 interactors: ACTN3 ADAM12 ADORA2A ANG ATXN2 ATXN7 BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 COIL DISC1 DLG1 DLG4 EPS8L1 ERBB2IP FAM154A FBXL22 GRIN1 GRIN2B ITGB3BP KAT2B KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MED14 MICALL2 MOS MYOZ1 MYOZ2 MYOZ3 MYPN NCOA2 NCOR1 NOS3 NR1I2 NRIP1 PALLD PDLIM1 PDLIM3 PKD2 RAVER1 RPL35 RTP5 SELE SNAI1 SNW1 SP100 SSX2IP ST7 SYNPO2 TNN TTN UTRN ZNF446
Entrez ID		5311	88
HPRD ID		01437	00019
Ensembl ID		ENSG00000118762	ENSG00000077522
Uniprot IDs		Q13563 Q9UEU6	B2RCS5 P35609 Q59FD9
PDB IDs		2KLD 2KLE 2KQ6 2Y4Q 3HRN 3HRO	1H8B 1HCI 1QUU
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Regulation Of ATPase Activity Actin-mediated Cell Contraction Actin Filament-based Movement Regulation Of Cellular Localization Endomembrane System Organization Regulation Of Intracellular Transport Regulation Of Cytoskeleton Organization Positive Regulation Of ATPase Activity Cell Projection Organization Muscle Contraction Plasma Membrane Organization Regulation Of Actin Cytoskeleton Reorganization Protein Targeting To Plasma Membrane Actin Filament-based Process Ventricular Cardiac Muscle Tissue Morphogenesis Muscle System Process Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Muscle Tissue Morphogenesis Heart Contraction Regulation Of Protein Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Movement Of Cell Or Subcellular Component Metanephric Distal Tubule Morphogenesis Positive Regulation Of Heart Rate By Epinephrine Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Calcium Ion Transport Into Cytosol Establishment Of Protein Localization To Plasma Membrane Striated Muscle Contraction Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cellular Metal Ion Homeostasis Protein Kinase D Signaling Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Regulation Of Systemic Arterial Blood Pressure Cellular Cation Homeostasis Regulation Of Peptidyl-serine Phosphorylation Cellular Ion Homeostasis Cardiac Ventricle Development Metal Ion Homeostasis Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity	Cytoskeleton Organization Regulation Of Ion Transport Organelle Organization Cell Communication Actin Filament-based Process Signaling Cellular Component Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Ion Transmembrane Transport Anatomical Structure Development Synaptic Transmission Positive Regulation Of Metabolic Process Cell Development Signal Transduction Movement Of Cell Or Subcellular Component Cell Differentiation Cell-cell Signaling Regulation Of Cellular Process Rhythmic Process Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Actin Cytoskeleton Organization Anatomical Structure Morphogenesis Protein Complex Assembly Regulation Of Potassium Ion Transport Striated Muscle Cell Differentiation Regulation Of Signaling Anatomical Structure Formation Involved In Morphogenesis Response To Organic Substance Regulation Of Sodium Ion Transport Response To Abiotic Stimulus Muscle System Process Negative Regulation Of Transport Striated Muscle Cell Development Positive Regulation Of Cellular Biosynthetic Process Myofibril Assembly Establishment Or Maintenance Of Apical/basal Cell Polarity Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Muscle Cell Development Cellular Calcium Ion Homeostasis Regulation Of Receptor Internalization Regulation Of Cellular Response To Heat Response To Stimulus Regulation Of Histone Deacetylase Activity Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Locomotion Negative Regulation Of Ion Transport
Tagcloud ?		acts adpkd autosomal chaperone coil coiled complexing determinant disrupted distal glycoform gps heterozygotes illustrating inherited interbreeding maturation mature missense nephropathy nonequimolar pathogenic pc1 pc2 pkd1 polycystic polycystin progressive severity	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Difference) ?		acts adpkd autosomal chaperone coil coiled complexing determinant disrupted distal glycoform gps heterozygotes illustrating inherited interbreeding maturation mature missense nephropathy nonequimolar pathogenic pc1 pc2 pkd1 polycystic polycystin progressive severity	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Intersection) ?