PKD2 and DIAPH1

Number of citations of the paper that reports this interaction (PubMedID 15123714)
0

Data Source:
HPRD (in vivo)

		PKD2	DIAPH1
Description		polycystin 2, transient receptor potential cation channel	diaphanous related formin 1
Image
GO Annotations	Cellular Component	Polycystin Complex Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction Cilium Basal Plasma Membrane Membrane Basolateral Plasma Membrane Lamellipodium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Motile Cilium Vesicle Monoatomic Ion Channel Complex Cation Channel Complex Ciliary Basal Body Cell Projection Basal Cortex Ciliary Membrane Extracellular Exosome Mitotic Spindle Non-motile Cilium Lumenal Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane Migrasome	Nucleus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Actin Filament Plasma Membrane Membrane Secretory Granule Membrane Ruffle Membrane Cell Projection Mitotic Spindle Ficolin-1-rich Granule Membrane
	Molecular Function	Signaling Receptor Binding Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Potassium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Channel Activity Outward Rectifier Potassium Channel Activity Voltage-gated Monoatomic Cation Channel Activity Identical Protein Binding Protein Homodimerization Activity Actinin Binding HLH Domain Binding Transmembrane Transporter Binding Metal Ion Binding Calcium-induced Calcium Release Activity ATPase Binding Phosphoprotein Binding Muscle Alpha-actinin Binding Transcription Regulator Inhibitor Activity	RNA Binding Actin Binding Signaling Receptor Binding Protein Binding Small GTPase Binding Transmembrane Transporter Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Liver Development Embryonic Placenta Development Heart Looping Detection Of Nodal Flow Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Determination Of Left/right Symmetry Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Wnt Signaling Pathway Calcium-mediated Signaling Spinal Cord Development Neural Tube Development Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Metanephric Part Of Ureteric Bud Development Sodium Ion Transmembrane Transport Aorta Development Regulation Of Cell Population Proliferation Chordate Embryonic Development Cilium Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Detection Of Mechanical Stimulus Release Of Sequestered Calcium Ion Into Cytosol Protein Tetramerization Protein Homotetramerization Protein Heterotetramerization Centrosome Duplication Establishment Of Localization In Cell Regulation Of Cell Cycle Placenta Blood Vessel Development Renal Tubule Morphogenesis Renal Artery Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Hydrostatic Pressure Cellular Response To Osmotic Stress Cellular Response To Fluid Shear Stress Potassium Ion Transmembrane Transport Determination Of Liver Left/right Asymmetry Metanephric Mesenchyme Development Mesonephric Tubule Development Mesonephric Duct Development Metanephric Smooth Muscle Tissue Development Metanephric Cortex Development Metanephric Ascending Thin Limb Development Metanephric Cortical Collecting Duct Development Metanephric Distal Tubule Development Metanephric S-shaped Body Morphogenesis Regulation Of Calcium Ion Import Inorganic Cation Transmembrane Transport Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Cytoskeleton Organization Sensory Perception Of Sound Regulation Of Cell Shape Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Microtubule-based Process Protein Localization To Microtubule Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytoskeleton Organization Cellular Response To Histamine
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	RHO GTPases Activate Formins ERBB2 Regulates Cell Motility Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RHOD GTPase cycle RHOF GTPase cycle Regulation of MITF-M dependent genes involved in invasion
Drugs
Diseases		Polycystic kidney disease
GWAS		Coffee consumption (cups per day) ( 25288136) Dental caries ( 23064961) Gout ( 30899057) Hyperuricemia ( 28776340) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels in response to allopurinol in gout ( 25676789) Uric acid levels ( 29558500)	Age at first birth ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29083406) Femur bone mineral density x serum urate levels interaction ( 34046847) Mean platelet volume ( 27863252 32888494) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		21 interacting genes: ACTN2 CD2AP CYSRT1 DIAPH1 HAX1 HSF2BP KRT40 KRTAP10-3 KRTAP10-8 KRTAP6-2 LMNA MAGEA8 MDFI PACS1 PACS2 PKD1 PLSCR1 PTPRG TNNI3 TPM1 TRPC1	18 interacting genes: APBB1 BAIAP2 CDC42 CDC7 CENPA EGFR GAS7 NEDD4 PAX6 PKD2 PRPF40A PTPRF RAC1 RHOA RHOC TCERG1 WBP4 XPO6
Entrez ID		5311	1729
HPRD ID		01437	03670
Ensembl ID		ENSG00000118762	ENSG00000131504
Uniprot IDs		Q13563 Q9UEU6	A0A2R8Y5N1 O60610 Q6URC4
PDB IDs		2KLD 2KLE 2KQ6 2Y4Q 3HRN 3HRO 5K47 5MKE 5MKF 5T4D 6A70 6D1W 6T9N 6T9O 6WB8 8HK7 8K3S 9DLI 9DWQ	8FG1
Enriched GO Terms of Interacting Partners?		Transmembrane Transporter Binding Intermediate Filament Actin Filament Sarcomere Alcohol Dehydrogenase (NAD+) Activity Actin Filament Binding Striated Muscle Cell Development Regulation Of Cytoskeleton Organization Actin Binding Cytosol All-trans-retinol Dehydrogenase (NAD+) Activity Cation Channel Complex Actin-myosin Filament Sliding Muscle Filament Sliding Protein Domain Specific Binding Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Keratin Filament Muscle Cell Development Structural Constituent Of Cytoskeleton Regulation Of Muscle System Process Positive Regulation Of Cation Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Retinoic Acid Metabolic Process Protein Heterooligomerization Actin Cytoskeleton Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Actin Filament Uncapping Identical Protein Binding Butanol Dehydrogenase (NAD+) Activity Ethanol Dehydrogenase (NAD+) Activity Actin Filament Polymerization Regulation Of Calcium Ion Transmembrane Transport Regulation Of System Process S-methyl-5-thioadenosine Phosphorylase Activity Metanephric Distal Tubule Morphogenesis Monoatomic Cation Channel Activity Regulation Of ATP-dependent Activity Negative Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Positive Regulation Of Heart Rate By Epinephrine Actin-mediated Cell Contraction	Proline-rich Region Binding Cell Projection Morphogenesis Neuron Projection Morphogenesis Positive Regulation Of Stress Fiber Assembly Anatomical Structure Morphogenesis Cell Projection Organization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Skeletal Muscle Satellite Cell Migration Lamellipodium Cell Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Stress Fiber Assembly Regulation Of Cell Projection Organization Cerebral Cortex Cell Migration Cell Motility Regulation Of Cell Cycle Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Actin Filament Organization Regulation Of Actin Filament Organization Neuron Projection Development Telencephalon Cell Migration Regulation Of Synapse Organization Forebrain Cell Migration Membrane Invagination Plasma Membrane Bounded Cell Projection Organization Non-canonical Wnt Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Lipase Activity Apical Junction Assembly Regulation Of Cell Division Cell-cell Junction Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Mitotic Cytokinesis Thioesterase Binding Salivary Gland Morphogenesis Positive Regulation Of Protein-containing Complex Assembly G Protein Activity Regulation Of Cell Cycle Regulation Of Protein-containing Complex Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Neuron Projection Development Protein Kinase Binding Postsynapse Cell Junction Organization Regulation Of Cytokinesis
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