NEUROD1 and MAFA

Number of citations of the paper that reports this interaction (PubMedID 15665000)
0

Data Source:
HPRD (in vivo, in vitro)

		NEUROD1	MAFA
Description		neuronal differentiation 1	MAF bZIP transcription factor A
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Via JAK-STAT Nervous System Development Sensory Organ Development Response To Glucose Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebellum Development Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Cell Differentiation Hindbrain Development Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Amacrine Cell Differentiation Enteroendocrine Cell Differentiation Glucose Homeostasis Camera-type Eye Development Positive Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Embryonic Organ Morphogenesis Inner Ear Development Regulation Of Insulin Secretion Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intestinal Epithelial Structure Maintenance Axon Development Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Glucose Insulin Secretion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	Regulation of gene expression in beta cells
Drugs
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Nonsyndromic cleft palate ( 31609978)
Interacting Genes		15 interacting genes: CALM1 CALM2 CALM3 DUSP3 EP300 HAP1 MAFA MAP3K10 NR0B2 PDX1 PITX1 RREB1 TCF12 TCF3 TCF4	6 interacting genes: HERC4 MAF MAPK1 MAPK14 NEUROD1 PDX1
Entrez ID		4760	389692
HPRD ID		03428	14346
Ensembl ID		ENSG00000162992	ENSG00000182759
Uniprot IDs		A0A0S2Z493 Q13562	Q8NHW3
PDB IDs			4EOT
Enriched GO Terms of Interacting Partners?		Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calyx Of Held Regulation Of Monoatomic Ion Transmembrane Transporter Activity DNA-binding Transcription Factor Activity Catalytic Complex Chromatin Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Transcription Regulator Complex Calcineurin-mediated Signaling Presynaptic Cytosol BHLH Transcription Factor Binding Myelin Sheath Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Sequestering Of Calcium Ion Positive Regulation Of RNA Metabolic Process Negative Regulation Of Calcium Ion Transmembrane Transport Transmembrane Transporter Binding Spindle Microtubule Positive Regulation Of Synaptic Transmission Regulation Of Calcium Ion Transmembrane Transport Presynaptic Endocytosis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Substantia Nigra Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Calcium Channel Regulator Activity Nucleus Sperm Midpiece Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle	Transcription By RNA Polymerase II Negative Regulation Of Type B Pancreatic Cell Apoptotic Process DNA-templated Transcription Cell Differentiation Response To Nutrient Levels Enteroendocrine Cell Differentiation MAP Kinase Activity Endocrine Pancreas Development Cellular Developmental Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Protein Transport Response To Lipid Lipopolysaccharide-mediated Signaling Pathway Nucleobase-containing Compound Biosynthetic Process Response To Nicotine Positive Regulation Of Nucleobase-containing Compound Metabolic Process Insulin Secretion Positive Regulation Of Establishment Of Protein Localization Regulation Of Epithelial Cell Apoptotic Process Inner Ear Development Epithelial Cell Differentiation Peptide Hormone Secretion Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Transport Positive Regulation Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Acadesine Embryonic Morphogenesis Sequence-specific DNA Binding Positive Regulation Of Insulin Secretion DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Peptide Secretion Regulation Of Ossification Regulation Of Cellular Localization Stem Cell Differentiation Animal Organ Development Homeostatic Process Regulation Of Establishment Of Protein Localization Anatomical Structure Morphogenesis Ficolin-1-rich Granule Lumen Negative Regulation Of Signaling Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Response To Peptide Response To Tumor Necrosis Factor RNA Metabolic Process Macromolecule Metabolic Process
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