NEUROD1 and RREB1

Number of citations of the paper that reports this interaction (PMID 12482979)
13

Data Source:
HPRD (in vitro)

		NEUROD1	RREB1
Gene Name		neuronal differentiation 1	ras responsive element binding protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Body Nuclear Speck Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity E-box Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding
	Biological Process	Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Transcription, DNA-templated Nucleocytoplasmic Transport Nitric Oxide Mediated Signal Transduction Response To Glucose Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebellum Development Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Endocrine Pancreas Development Amacrine Cell Differentiation Enteroendocrine Cell Differentiation Response To Drug Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JAK-STAT Cascade Embryonic Organ Morphogenesis Inner Ear Development Regulation Of Insulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Intestinal Epithelial Structure Maintenance Regulation Of Cell Cycle Arrest Cellular Response To Glucose Stimulus Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Transcription Regulatory Region DNA Binding	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Ras Protein Signal Transduction Multicellular Organismal Development Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Regulation of beta-cell development Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Regulation of gene expression in beta cells
Drugs
Diseases
GWAS			Age-related macular degeneration ( 20385826) Fasting glucose-related traits (interaction with BMI) ( 22581228) Multiple sclerosis ( 21833088) Urate levels ( 20884846 23263486) Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		12 interactors: CALM1 CALM2 CALM3 DUSP3 EP300 HAP1 MAFA MAP3K10 PDX1 PITX1 RREB1 TCF4	2 interactors: HIST3H3 NEUROD1
Entrez ID		4760	6239
HPRD ID		03428	03733
Ensembl ID		ENSG00000162992	ENSG00000124782
Uniprot IDs		Q13562	Q92766
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cation Channel Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Cellular Biosynthetic Process Second-messenger-mediated Signaling Positive Regulation Of Metabolic Process Glucose Metabolic Process Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Glycogen Metabolic Process Intracellular Signal Transduction Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Hexose Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Cation Channel Activity Positive Regulation Of Ion Transmembrane Transport Neurotrophin Signaling Pathway Polysaccharide Metabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Secretion By Cell Positive Regulation Of Nitric-oxide Synthase Activity Cell Surface Receptor Signaling Pathway Monosaccharide Metabolic Process Regulation Of Cell Cycle Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Glycogen Catabolic Process Positive Regulation Of Calcium Ion Transport Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Central Nervous System Development Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Response To Stress Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Organic Substance	Pancreatic A Cell Fate Commitment Regulation Of Intestinal Epithelial Structure Maintenance Pancreatic PP Cell Fate Commitment Amacrine Cell Differentiation Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Pancreatic A Cell Differentiation Positive Regulation Of Transcription Regulatory Region DNA Binding Nitric Oxide Mediated Signal Transduction Dentate Gyrus Development Negative Regulation Of JAK-STAT Cascade Epithelial Cell Fate Commitment Regulation Of Transcription Regulatory Region DNA Binding Enteroendocrine Cell Differentiation Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of DNA Binding Homeostatic Process Insulin Secretion Glandular Epithelial Cell Differentiation Endocrine Pancreas Development Neural Retina Development Cellular Response To Glucose Stimulus Peptide Hormone Secretion Peptide Secretion Hippocampus Development Cellular Glucose Homeostasis Telomere Maintenance Cellular Response To Carbohydrate Stimulus Hormone Secretion Regulation Of DNA Binding Regulation Of JAK-STAT Cascade Hormone Transport Peptide Transport Pancreas Development Regulation Of Cell Cycle Arrest Limbic System Development Cerebellum Development Positive Regulation Of Binding
Tagcloud ?		aa ad1 ad2 beta2 carboxy cbp chimeras coactivator constructs convert creb ectoderm ectopic embryos evolutionarily gal4 helix implicate islet morphogenesis precursors premature separable spanning transactivation utilized xenopus	11q13 6p25 atf1 braf clear confirming cytokeratins diastase epidermotropic epithelioid ewsr1 gains glycogen histologic hmb intracytoplasmic labeling melan melanoma morphologic p63 periodic perivascular rule s100 sarcoma schiff ulcerated v600e
Tagcloud (Difference) ?		aa ad1 ad2 beta2 carboxy cbp chimeras coactivator constructs convert creb ectoderm ectopic embryos evolutionarily gal4 helix implicate islet morphogenesis precursors premature separable spanning transactivation utilized xenopus	11q13 6p25 atf1 braf clear confirming cytokeratins diastase epidermotropic epithelioid ewsr1 gains glycogen histologic hmb intracytoplasmic labeling melan melanoma morphologic p63 periodic perivascular rule s100 sarcoma schiff ulcerated v600e
Tagcloud (Intersection) ?