ZBTB9 and DYRK2

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		ZBTB9	DYRK2
Name		zinc finger and BTB domain containing 9	dual specificity tyrosine phosphorylation regulated kinase 2
Structure
GO Annotations	Cellular Component	Nucleus	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Protein-containing Complex Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Manganese Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Protein Phosphorylation Apoptotic Process DNA Damage Response Smoothened Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction By P53 Class Mediator
Pathways		None	Regulation of TP53 Activity through Phosphorylation
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Crohn's disease or systemic sclerosis ( 32024964 ) Diastolic blood pressure ( 27841878 ) Lung cancer ( 28604730 )	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728 ) Daytime sleep phenotypes ( 27126917 ) Itch intensity from mosquito bite ( 28199695 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Malaria ( 31844061 ) Metabolite levels ( 23823483 ) Mosquito bite size ( 28199695 ) Peak height velocity ( 34047840 ) Systemic lupus erythematosus ( 28714469 )
Interacting Genes		47 interacting genes: CAPN7 CBX8 CDYL2 CHURC1 CIB4 CKS1B DTNB DYRK2 EHHADH EIF4E2 GTF2E1 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 LASP1 MCM6 MDFI MORF4L1 MYBL2 NFKB1 NR3C1 PARP1 PIN1 PIN4 PPARG PPARGC1B SNIP1 SYTL4 TCEA2 TCEANC TSPYL1 TSR2 UBE2I ZBTB24 ZBTB26 ZBTB48 ZFP64 ZFY ZKSCAN5 ZNF23 ZNF407 ZNF408 ZNF417 ZNF71 ZZZ3	23 interacting genes: APP ATM DYRK4 EIF2B5 FBXW7 H2BC21 H3-4 IKZF1 KATNA1 KXD1 LRRK2 LZTS2 MAPT MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBE2D1 UBR5 WDR62 ZBTB9
Entrez ID		221504	8445
HPRD ID		15695	04606
Ensembl ID		ENSG00000213588	ENSG00000127334
Uniprot IDs		A0A1U9X8U5 Q96C00	Q92630
PDB IDs		9B9V	3K2L 3KVW 4AZF 5LXC 5LXD 5ZTN 6HDP 6HDR 6K0J 7AKF 7AKH 7DG4 7DH3 7DH9 7DHC 7DHH 7DHK 7DHN 7DHO 7DHV 7DJO 7DL6 8HLT
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding DNA Binding Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Intermediate Filament Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Keratin Filament Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Histone H3K27me3 Reader Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Adipose Tissue Development Positive Regulation Of MiRNA Metabolic Process Parental Behavior Nucleoplasm Regulation Of SMAD Protein Signal Transduction DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific	Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Localization Regulation Of Wnt Signaling Pathway Regulation Of Establishment Of Protein Localization Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Nucleus Negative Regulation Of Cell Communication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Determination Of Adult Lifespan Cellular Response To Reactive Oxygen Species Regulation Of Canonical Wnt Signaling Pathway Main Axon Cellular Response To Stress DNA Binding Proteasomal Protein Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Biosynthetic Process Cellular Response To Manganese Ion Regulation Of Protein Localization To Nucleus Regulation Of Cellular Response To Stress Identical Protein Binding Response To Reactive Oxygen Species DNA Damage Response DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Distribution Of Mitochondria Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Microtubule Severing Response To Metal Ion Regulation Of Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Chromosome, Telomeric Region Response To Oxidative Stress Positive Regulation Of Neuron Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Stability Protein Ubiquitination Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Proteolysis Response To Manganese Ion Regulation Of Gene Expression Positive Regulation Of Protein Catabolic Process Cellular Response To Oxidative Stress Regulation Of Signal Transduction Replicative Senescence