NAB2 and EXOC8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NAB2	EXOC8
Description		NGFI-A binding protein 2	exocyst complex component 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Exocyst Cytoplasm Late Endosome Cytosol Plasma Membrane Membrane Growth Cone Cell Projection Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Identical Protein Binding	Protein Binding Small GTPase Binding Phosphatidylinositol Binding
	Biological Process	Endochondral Ossification Regulation Of DNA-templated Transcription Schwann Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase III Myelination Regulation Of Epidermis Development Negative Regulation Of DNA-templated Transcription	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Endosome Organization Intracellular Protein Localization Protein Transport Regulation Of Macroautophagy Extracellular Matrix Disassembly Membrane Fission Vesicle Tethering Involved In Exocytosis
Pathways		NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 29273806 31361310 31619474 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) IgE levels ( 22075330) Schizophrenia ( 25056061 29483656)	Hemoglobin concentration ( 27863252)
Interacting Genes		80 interacting genes: ANK3 ANKRD11 CBX8 CCDC187 CCDC33 CCDC57 CCHCR1 CDC23 CTAG1A CTAG1B CTNNA3 CWF19L2 DDX6 DGCR6 DGCR6L DRG2 EGR1 EGR2 ELOA ENKD1 EXOC8 FAM200C FAM9A GCC1 GOLGA6L9 HSF2BP JAKMIP2 KIF9 KIFC3 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LENG1 LMNA LNX1 MAPK3 MCM7 MCRS1 MDFI MORF4L1 MORF4L2 NDOR1 NEDD9 NME7 NOTCH2NLA NTAQ1 PHF1 PHOSPHO2 PIK3R3 PIN1 PLOD3 PRKAA2 PRKAB2 PSMA1 QARS1 RBPMS RFC5 RINT1 SCNM1 SMARCD1 SORBS3 SPG21 SUMO1P1 TCEA2 TCEANC TCHP TGIF2LY TLE5 TRAF2 TRIM23 TSGA10 TSGA10IP TTC19 USP2 UTP14C ZMAT2 ZMYND12 ZMYND19 ZNF417	88 interacting genes: AIMP2 ANKRD36B ATP23 BEX2 BICRAL BLOC1S2 BLOC1S6 BLZF1 BORCS6 CAPN3 CCDC33 CCDC85B CCHCR1 CDSN CEP57L1 CWF19L2 DMAP1 EFHC2 ELL2 ESS2 EXOC2 FAM217B GOLGA2 GRAMD4 GTF2E2 HGS IHO1 IKZF3 ISY1 ISY1-RAB43 KIAA1217 KIFC3 KRT15 KRT18 KRT19 KRT20 KRT31 KRT34 KRT36 KRT76 LNX1 LZTS1 MARCHF7 MBD3L1 MBIP MIPOL1 MTUS2 MYOZ3 NAB2 NDC80 NUP54 PBX4 PCM1 PRR35 RAB3IL1 RALA RAPGEF3 RINT1 RUSC1 SASH1 SCARA5 SNAPC1 STMN3 SYCE1 SYT17 TADA2A TBC1D22B TCF12 TCF4 TFIP11 TRIM14 TRIM21 TRIM27 TRIM54 ULK1 UQCC2 USHBP1 USP54 VPS16 VPS37B WASHC1 ZC2HC1A ZNF177 ZNF35 ZNF559-ZNF177 ZNF566 ZNF628 ZSCAN4
Entrez ID		4665	149371
HPRD ID		03854	09943
Ensembl ID		ENSG00000166886	ENSG00000116903
Uniprot IDs		Q15742	Q8IYI6
PDB IDs
Enriched GO Terms of Interacting Partners?			Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Protein Binding Supramolecular Fiber Organization Intermediate Filament Organelle Organization Structural Molecule Activity Negative Regulation Of Viral Transcription Cytoskeleton Regulation Of Viral Transcription Regulation Of Post-translational Protein Modification Regulation Of Protein Autoubiquitination Molecular Adaptor Activity Cytoskeleton Organization Identical Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity Cellular Localization Vesicle-mediated Transport To The Plasma Membrane Regulation Of Lysosome Size BORC Complex Post-mRNA Release Spliceosomal Complex Gamma-tubulin Binding Autophagosome Epidermis Development
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