NAB2 and EGR1

Number of citations of the paper that reports this interaction (PubMedID 8668170)
51

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NAB2	EGR1
Description		NGFI-A binding protein 2	early growth response 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Identical Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Enzyme Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Endochondral Ossification Regulation Of DNA-templated Transcription Schwann Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase III Myelination Regulation Of Epidermis Development Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Response To Ischemia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Glucose Positive Regulation Of Gene Expression T Cell Differentiation BMP Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Protein Sumoylation Skeletal Muscle Cell Differentiation Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Estrous Cycle Locomotor Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Biosynthetic Process Rhythmic Process Circadian Temperature Homeostasis Interleukin-1-mediated Signaling Pathway Cellular Response To Gamma Radiation Cellular Response To Heparin Cellular Response To Mycophenolic Acid Glomerular Mesangial Cell Proliferation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Interleukin-8 Positive Regulation Of Post-translational Protein Modification Positive Regulation Of MiRNA Transcription Regulation Of Progesterone Biosynthetic Process
Pathways		NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination	Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription NGF-stimulated transcription Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 29273806 31361310 31619474 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) IgE levels ( 22075330) Schizophrenia ( 25056061 29483656)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Autism spectrum disorder or schizophrenia ( 28540026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 25056061 28991256)
Interacting Genes		80 interacting genes: ANK3 ANKRD11 CBX8 CCDC187 CCDC33 CCDC57 CCHCR1 CDC23 CTAG1A CTAG1B CTNNA3 CWF19L2 DDX6 DGCR6 DGCR6L DRG2 EGR1 EGR2 ELOA ENKD1 EXOC8 FAM200C FAM9A GCC1 GOLGA6L9 HSF2BP JAKMIP2 KIF9 KIFC3 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LENG1 LMNA LNX1 MAPK3 MCM7 MCRS1 MDFI MORF4L1 MORF4L2 NDOR1 NEDD9 NME7 NOTCH2NLA NTAQ1 PHF1 PHOSPHO2 PIK3R3 PIN1 PLOD3 PRKAA2 PRKAB2 PSMA1 QARS1 RBPMS RFC5 RINT1 SCNM1 SMARCD1 SORBS3 SPG21 SUMO1P1 TCEA2 TCEANC TCHP TGIF2LY TLE5 TRAF2 TRIM23 TSGA10 TSGA10IP TTC19 USP2 UTP14C ZMAT2 ZMYND12 ZMYND19 ZNF417	27 interacting genes: CDKN2A CEBPB CRBN CREBBP CSNK2A1 DNMT3L EP300 ERBB3 IL1B JUN MTDH NAB1 NAB2 NEAT1 NEDD4 NFATC1 NFATC2 NGFR PITX1 PSMA3 RELA SNCA SP1 SRA1 SREBF2 TP53 WT1
Entrez ID		4665	1958
HPRD ID		03854	00549
Ensembl ID		ENSG00000166886	ENSG00000120738
Uniprot IDs		Q15742	P18146 Q546S1
PDB IDs			4R2A 4R2C 4R2D 4X9J 5N14
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Positive Regulation Of MiRNA Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Intracellular Signaling Cassette Transcription Regulator Complex Regulation Of Developmental Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Signal Transduction Chromatin DNA-binding Transcription Factor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Schwann Cell Differentiation NF-kappaB Binding Cellular Response To Stress Regulation Of Signal Transduction
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