ATP5PF and BCL2L2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ATP5PF	BCL2L2
Name		ATP synthase peripheral stalk subunit F6	BCL2 like 2
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Proton-transporting ATP Synthase Complex	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism	Protein Binding Channel Activity Identical Protein Binding Disordered Domain Specific Binding
	Biological Process	Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Substantia Nigra Development Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport	Release Of Cytochrome C From Mitochondria Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Sertoli Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Formation of ATP by chemiosmotic coupling Cristae formation Mitochondrial protein degradation	None
Drugs		None	Navitoclax
GWAS		No GWAS studies recorded	Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 )
Interacting Genes		17 interacting genes: ABHD16A BCL2L2 INPP5K KCNK5 MALL MAPK6 MIEF1 MIEF2 MOSPD3 NDRG4 PHOSPHO2 PLP2 PTPN9 REEP6 RPS6KA3 SFT2D2 SIGLEC12	53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CEBPA CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35E3 SLC35H1 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53
Entrez ID		522	599
HPRD ID		04399	03569
Ensembl ID		ENSG00000154723	ENSG00000129473
Uniprot IDs		P18859 Q6IB54 Q6NZ59	Q92843
PDB IDs		8H9G 8H9K 8H9N 8H9R 8H9S 8H9T 8H9U 8H9V 8KI3	1MK3 1O0L 1ZY3 2Y6W 4CIM
GO Terms Enriched among Interactors		Regulation Of Cellular Localization Regulation Of Protein Targeting To Membrane Positive Regulation Of Mitochondrial Fission Mitochondrial Fusion Positive Regulation Of Protein Targeting To Membrane Regulation Of Mitochondrial Fission	Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Apoptotic Mitochondrial Changes Apoptotic Process Positive Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Cell Death Positive Regulation Of Programmed Cell Death Programmed Cell Death Mitochondrial Outer Membrane Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Apoptotic Signaling Pathway Regulation Of Membrane Permeability Mitochondrion Organization Cellular Response To Stress Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein-containing Complex Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Fibroblast Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Apoptotic Process Bcl-2 Family Protein Complex Positive Regulation Of Organelle Organization Positive Regulation Of Fibroblast Apoptotic Process Cellular Response To Hypoxia Lymphocyte Apoptotic Process Thymocyte Apoptotic Process Cellular Response To Decreased Oxygen Levels Regulation Of Protein-containing Complex Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Triglyceride Metabolic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxygen Levels Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Identical Protein Binding Leukocyte Apoptotic Process Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrion Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death