ATP5PF and RPS6KA3

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		ATP5PF	RPS6KA3
Name		ATP synthase peripheral stalk subunit F6	ribosomal protein S6 kinase A3
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Proton-transporting ATP Synthase Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Substantia Nigra Development Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport	Skeletal System Development Toll-like Receptor Signaling Pathway Signal Transduction Chemical Synaptic Transmission Central Nervous System Development Positive Regulation Of Cell Growth Response To Lipopolysaccharide Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of ATP by chemiosmotic coupling Cristae formation Mitochondrial protein degradation	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		None	Acetylsalicylic acid Fostamatinib
Diseases		None	Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)
GWAS		No GWAS studies recorded	Refractive error ( 32231278 )
Novel Interactors		None recorded	1 novel interactors: DPYD
Interacting Genes		17 interacting genes: ABHD16A BCL2L2 INPP5K KCNK5 MALL MAPK6 MIEF1 MIEF2 MOSPD3 NDRG4 PHOSPHO2 PLP2 PTPN9 REEP6 RPS6KA3 SFT2D2 SIGLEC12	44 interacting genes: ATM ATP5PF BAD BARX1 CREB1 CREBBP CTNND1 EIF3C ESR1 FBXO7 FGF2 FGFR3 FYN GRIN1 GRIN2D H2AX H3-4 H3C1 HMGN1 HMGN2 HTR2A ILKAP KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 MLST8 MTOR NEDD4 NFKBIA NR4A1 PDPK1 PEA15 RPTOR SHANK1 SMS SRC STAT3 STK11 SUMO2 TP53 YBX1
Entrez ID		522	6197
HPRD ID		04399	02092
Ensembl ID		ENSG00000154723	ENSG00000177189
Uniprot IDs		P18859 Q6IB54 Q6NZ59	A0A384MDW3 B1AXG1 B4DG22 B7ZB17 P51812
PDB IDs		8H9G 8H9K 8H9N 8H9R 8H9S 8H9T 8H9U 8H9V 8KI3	4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L 7OPO 8EQ5 8R58 8XEY 8XFY
GO Terms Enriched among Interactors		Regulation Of Cellular Localization Regulation Of Protein Targeting To Membrane Positive Regulation Of Mitochondrial Fission Mitochondrial Fusion Positive Regulation Of Protein Targeting To Membrane Regulation Of Mitochondrial Fission	Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Autophagy Regulation Of Carbohydrate Catabolic Process Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Pentose-phosphate Shunt Positive Regulation Of ATP Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Intracellular Signaling Cassette Regulation Of NADP Metabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Glycolytic Process DNA Damage Response Positive Regulation Of Phosphate Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Regulation Of Protein Stability Regulation Of Immune System Process Negative Regulation Of Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cellular Response To Heat Protein Localization To Organelle Regulation Of Cell Population Proliferation Positive Regulation Of Pentose-phosphate Shunt Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Response To Stress Regulation Of TOR Signaling Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process