RSRC2 and KASH5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RSRC2	KASH5
Description		arginine and serine rich coiled-coil 2	KASH domain containing 5
Image		No pdb structure
GO Annotations	Cellular Component		Chromosome, Telomeric Region Lateral Element Nucleus Nuclear Envelope Nuclear Outer Membrane Chromosome Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Meiotic Spindle Pole
	Molecular Function	RNA Binding Protein Binding	Protein Binding Identical Protein Binding Dynein Complex Binding
	Biological Process		Double-strand Break Repair Via Homologous Recombination Actin Filament Organization Homologous Chromosome Pairing At Meiosis Spermatogenesis Telomere Localization Meiotic Telomere Clustering Oogenesis Spindle Assembly Meiotic Cell Cycle Spindle Localization Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation
Pathways
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: AKAP9 APP CMTM5 CTAG1A CTAG1B GOLGA2 KASH5 NAV1 OGT PFDN5 PNMA1 RINT1 SAMD4B SRPK1 SRPK2 TRIM23 TRIM54 UBQLN1 UBQLN2 UBQLN4 UPF2	112 interacting genes: ABHD1 ADIPOQ ANKRD46 ATF7 BAG5 BCL2L2 BET1 C14orf180 CCDC120 CCDC87 CDC73 CDKL3 CIB3 CLDN8 CMTM5 CRABP2 CTXN3 CWF19L2 CXCL16 CXCL9 CYBC1 DERL1 DNAJC30 EFNA5 EMD FAM161A FAM241B FAM50B FAM90A1 FATE1 FIS1 FRA10AC1 FTCD FXYD3 GABARAPL2 GALNT2 GIMAP5 GOSR2 GPATCH4 GPR25 HMOX1 ITGAM ITM2B JAGN1 KDM1A LARP1 LAT LENG1 LHFPL5 LMNA LRCH4 MALL MARCHF2 MMP14 MOSPD3 MS4A1 MTX2 NRIP3 NSG1 NTAQ1 OLFM4 PDGFRA PGAP2 PGRMC1 PIGU PLP2 PLPP6 PPP1R18 RIPPLY2 RNF146 RSPH14 RSRC2 RTP2 SENP2 SERP2 SGTA SHMT2 SLC30A2 SLC35B4 SLC41A1 SLC41A2 SLC5A4 SLC61A1 SLN SMCO4 SNAP47 STBD1 STX12 STX5 TCF25 TMEM11 TMEM147 TMEM14C TMEM19 TMEM41A TMEM86A TMPRSS4 TNF TRAF3IP3 TRARG1 TSHZ3 TTC23 UPK1B UPK2 VAMP1 VAMP2 VAMP4 VMA12 VTI1B ZC2HC1C ZFPL1 ZNF250
Entrez ID		65117	147872
HPRD ID		13342	08134
Ensembl ID		ENSG00000111011	ENSG00000161609
Uniprot IDs		Q7L4I2	Q8N6L0
PDB IDs			6R2I 6WMF
Enriched GO Terms of Interacting Partners?		Cytoplasm Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Response To Stress Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Identical Protein Binding Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Amyloid Fibril Formation Positive Regulation Of ERAD Pathway Regulation Of Protein Metabolic Process Macromolecule Metabolic Process TRNA Threonylcarbamoyladenosine Metabolic Process Microtubule-based Process Autophagy Regulation Of ERAD Pathway Microtubule Nucleation Positive Regulation Of Viral Genome Replication Amyloid-beta Complex Innate Immune Response Growth Cone Lamellipodium Protein-containing Complex Organization Regulation Of Response To Calcium Ion Amylin Binding Cellular Component Assembly Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Defense Response RNA Polymerase III Assembly RNA Polymerase I Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Cellular Component Organization Organelle Assembly Cis-Golgi Network Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Regulation Of Macroautophagy Defense Response To Symbiont Regulation Of Glycolytic Process Defense Response To Other Organism Protein-containing Complex Nucleic Acid Metabolic Process Microtubule Cytoskeleton Organization Positive Regulation Of Protein Catabolic Process	Membrane SNARE Complex SNAP Receptor Activity Protein Binding Endoplasmic Reticulum Membrane Vesicle Fusion Organelle Fusion Organelle Membrane Fusion Membrane Fusion Endoplasmic Reticulum SNARE Binding Membrane Organization Localization Within Membrane Vesicle Organization Presynaptic Endosome Membrane SNARE Complex Assembly Mitochondrial Outer Membrane Establishment Of Protein Localization To Membrane Golgi Membrane Endosome To Plasma Membrane Protein Transport Positive Regulation Of Neutrophil Activation Regulation Of Cellular Localization Monoatomic Cation Transmembrane Transporter Activity Vesicle-mediated Transport Endomembrane System Establishment Of Protein Localization To Plasma Membrane
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