DGCR14 and WNK2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DGCR14	WNK2
Gene Name		DiGeorge syndrome critical region gene 14	WNK lysine deficient protein kinase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Catalytic Step 2 Spliceosome	Cytoplasm Plasma Membrane
	Molecular Function	Molecular_function Protein Binding	Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	MRNA Splicing, Via Spliceosome Nervous System Development	Protein Phosphorylation Negative Regulation Of Cell Proliferation Intracellular Signal Transduction Protein Autophosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Ion Homeostasis Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CDK5RAP3 CRP DHX16 FRA10AC1 GNB2L1 LYST PFDN1 RBM4 TTC14 VIM WNK2	4 interactors: ATXN1 DGCR14 WNK1 YWHAZ
Entrez ID		8220	65268
HPRD ID		03452	06951
Ensembl ID		ENSG00000100056	ENSG00000165238
Uniprot IDs		Q96DF8	F8W9F9 Q9Y3S1
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Translation Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of CAMP Catabolic Process Mast Cell Secretory Granule Organization Regulation Of Neuron Differentiation Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Ion Homeostasis Regulation Of Cell Differentiation IRES-dependent Translational Initiation Cap-independent Translational Initiation Regulation Of Neurogenesis Endosome Transport Via Multivesicular Body Sorting Pathway Circadian Regulation Of Translation Defense Response To Bacterium Negative Regulation Of Oxidative Stress-induced Neuron Death Bergmann Glial Cell Differentiation Negative Regulation Of Vasodilation Secretion Of Lysosomal Enzymes Protein Ufmylation Negative Regulation Of Translation In Response To Stress Regulation Of Cell Development Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Homooligomerization Positive Regulation Of Gastrulation Phospholipid Homeostasis Regulation Of Gene Expression Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cytoplasmic Translational Initiation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Mitochondrial Depolarization Opsonization Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Phagocytosis Regulation Of Translation Cell Differentiation Central Nervous System Development Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Superoxide Anion Generation Regulation Of Interleukin-8 Secretion Regulation Of Cellular Localization Rhythmic Process Regulation Of Metabolic Process Cytoplasmic Translation Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Translation In Response To Stress Negative Regulation Of Macrophage Derived Foam Cell Differentiation	Golgi Reassembly Negative Regulation Of Pancreatic Juice Secretion Histamine Secretion By Mast Cell Establishment Of Golgi Localization Golgi Inheritance Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Histamine Secretion Negative Regulation Of Phosphorylation Histamine Transport Positive Regulation Of Systemic Arterial Blood Pressure Golgi Localization Mast Cell Degranulation RNA Processing Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Mast Cell Mediated Immunity Lysosome Localization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mast Cell Activation Cytoplasmic Transport Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Leukocyte Degranulation Positive Regulation Of Blood Pressure Regulated Secretory Pathway Peptidyl-threonine Phosphorylation Cell-cell Signaling
Tagcloud ?			allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hist1h1c hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation
Tagcloud (Difference) ?			allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hist1h1c hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation
Tagcloud (Intersection) ?