ESS2 and WNK2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ESS2	WNK2
Description		ess-2 spliceosome associated protein	WNK lysine deficient protein kinase 2
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GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Catalytic Step 2 Spliceosome	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing	Protein Phosphorylation DNA Damage Response Negative Regulation Of Cell Population Proliferation Intracellular Signal Transduction Homeostatic Process Protein Autophosphorylation Monoatomic Ion Homeostasis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Stimuli-sensing channels
Drugs
Diseases
GWAS			Ability to confide in someone ( 29970889) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 33381925) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Perceived sweetness of sucrose ( 31005972)
Interacting Genes		33 interacting genes: ARMC7 CCDC57 CDK5RAP3 CEP55 CPSF7 CRP DGCR6 DHX16 EHMT2 EXOC8 EXOSC7 HOOK1 ITCH KRT31 LYST NEDD4 OGT OIP5 PFDN1 PRPF38B PRRC2B QARS1 RACK1 RBM22 RBM4 SMARCD1 THOC1 TRAK1 TTC14 UTP6 VIM WNK2 YAP1	6 interacting genes: ATXN1 ESS2 MTDH OXSR1 WNK1 YWHAZ
Entrez ID		8220	65268
HPRD ID		03452	06951
Ensembl ID		ENSG00000100056	ENSG00000165238
Uniprot IDs		F8WEF8 Q96DF8	E9PCD1 Q9Y3S1
PDB IDs		8C6J 8RO2 9FMD	6ELM 6FBK
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Cyclin Binding RNA Processing MRNA Metabolic Process MRNA Processing RNA Splicing Lysosomal Transport Positive Regulation Of Stem Cell Population Maintenance Endosome To Lysosome Transport Vacuolar Transport Negative Regulation Of MAPK Cascade RNA Binding Regulation Of Stem Cell Population Maintenance Spliceosomal Complex Molecular Adaptor Activity Proline-rich Region Binding Regulation Of Macroautophagy Pre-mRNA Binding	Chemokine (C-C Motif) Ligand 21 Signaling Pathway Cellular Response To Chemokine Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Positive Regulation Of Lymphocyte Chemotaxis Cellular Hyperosmotic Response Regulation Of Lymphocyte Chemotaxis Hyperosmotic Response Positive Regulation Of T Cell Migration Cell Volume Homeostasis Positive Regulation Of Lymphocyte Migration Cellular Response To Osmotic Stress Regulation Of T Cell Migration Protein Phosphorylation Phosphorylation Regulation Of Lymphocyte Migration Response To Osmotic Stress Chemokine-mediated Signaling Pathway Regulation Of Cell Size Protein Kinase Binding Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Monoatomic Ion Transport Synaptic Target Recognition Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Transmembrane Transporter Binding Regulation Of Mononuclear Cell Migration Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Potassium Ion Transmembrane Transport POZ Domain Binding Potassium Ion Transport Lymphocyte Migration Into Lymph Node Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Sodium Ion Transport Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Golgi Reassembly Negative Regulation Of Pancreatic Juice Secretion Phosphoserine Residue Binding Intercellular Canaliculus Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Localization Ion Channel Regulator Activity Regulation Of Chemotaxis Intracellular Membraneless Organelle Regulation Of Leukocyte Migration Poly(G) Binding Establishment Of Golgi Localization
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