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DGCR14 and CRP
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
DGCR14
CRP
Gene Name
DiGeorge syndrome critical region gene 14
C-reactive protein, pentraxin-related
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Catalytic Step 2 Spliceosome
Extracellular Region
Extracellular Space
Filopodium
Growth Cone
Extracellular Vesicular Exosome
Molecular Function
Molecular_function
Protein Binding
Complement Component C1q Binding
Calcium Ion Binding
Protein Binding
Cholesterol Binding
Low-density Lipoprotein Particle Binding
Choline Binding
Protein Homodimerization Activity
Virion Binding
Low-density Lipoprotein Particle Receptor Binding
Biological Process
MRNA Splicing, Via Spliceosome
Nervous System Development
Response To Hypoxia
Acute-phase Response
Inflammatory Response
Complement Activation, Classical Pathway
Aging
Opsonization
Response To Lead Ion
Positive Regulation Of Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Positive Regulation Of Superoxide Anion Generation
Wound Healing
Response To Ethanol
Negative Regulation Of Vasodilation
Defense Response To Gram-positive Bacterium
Protein Polymerization
Cellular Response To Calcium Ion
Positive Regulation Of Dendrite Development
Regulation Of Interleukin-8 Secretion
Pathways
Classical antibody-mediated complement activation
Creation of C4 and C2 activators
Complement cascade
Initial triggering of complement
Innate Immune System
Drugs
Phosphocholine
Diseases
GWAS
C-reactive protein (
22492993
19567438
21647738
18439548
18439552
21196492
21300955
22939635
)
Inflammatory biomarkers (
22291609
)
Lung cancer (
18385676
)
Metabolic traits (
19060910
)
Protein quantitative trait loci (
18464913
)
Select biomarker traits (
17903293
)
Protein-Protein Interactions
11 interactors:
CDK5RAP3
CRP
DHX16
FRA10AC1
GNB2L1
LYST
PFDN1
RBM4
TTC14
VIM
WNK2
20 interactors:
APCS
C1QA
CFH
DGCR14
FCGR1A
FCGR2A
FCGR2B
FN1
GLUD1
GMPPA
GP6
HIST1H1A
HIST1H2AL
HIST2H2AC
LAMC3
LEP
MAPK1
MAPK3
RPL13A
SNRNP70
Entrez ID
8220
1401
HPRD ID
03452
00422
Ensembl ID
ENSG00000100056
ENSG00000132693
Uniprot IDs
Q96DF8
P02741
PDB IDs
1B09
1CRV
1GNH
1LJ7
3L2Y
3PVN
3PVO
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Translation
Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway
Positive Regulation Of CAMP Catabolic Process
Mast Cell Secretory Granule Organization
Regulation Of Neuron Differentiation
Negative Regulation Of Hydrogen Peroxide-induced Neuron Death
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Regulation Of Ion Homeostasis
Regulation Of Cell Differentiation
IRES-dependent Translational Initiation
Cap-independent Translational Initiation
Regulation Of Neurogenesis
Endosome Transport Via Multivesicular Body Sorting Pathway
Circadian Regulation Of Translation
Defense Response To Bacterium
Negative Regulation Of Oxidative Stress-induced Neuron Death
Bergmann Glial Cell Differentiation
Negative Regulation Of Vasodilation
Secretion Of Lysosomal Enzymes
Protein Ufmylation
Negative Regulation Of Translation In Response To Stress
Regulation Of Cell Development
Negative Regulation Of Translation Involved In Gene Silencing By MiRNA
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Protein Homooligomerization
Positive Regulation Of Gastrulation
Phospholipid Homeostasis
Regulation Of Gene Expression
Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Cytoplasmic Translational Initiation
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Positive Regulation Of Mitochondrial Depolarization
Opsonization
Leukocyte Mediated Immunity
Adaptive Immune Response
Regulation Of Hydrogen Peroxide-induced Cell Death
Negative Regulation Of Phagocytosis
Regulation Of Translation
Cell Differentiation
Central Nervous System Development
Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Regulation Of Superoxide Anion Generation
Regulation Of Interleukin-8 Secretion
Regulation Of Cellular Localization
Rhythmic Process
Regulation Of Metabolic Process
Cytoplasmic Translation
Positive Regulation Of Sodium Ion Transmembrane Transport
Regulation Of Translation In Response To Stress
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Immune System Process
Innate Immune Response
Immune Response
Regulation Of Immune System Process
Defense Response
Regulation Of Golgi Inheritance
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Caveolin-mediated Endocytosis
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Positive Regulation Of Immune Response
JAK-STAT Cascade
Regulation Of Golgi Organization
Platelet Activation
Response To Stress
Regulation Of Early Endosome To Late Endosome Transport
Phagocytosis
Fc Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cellular Response To Cytokine Stimulus
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Growth Hormone Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cellular Response To Growth Hormone Stimulus
Response To Cytokine
Response To Epidermal Growth Factor
Regulation Of Cellular Response To Heat
Blood Coagulation
Hemostasis
Lipopolysaccharide-mediated Signaling Pathway
Acute-phase Response
Immune Response-regulating Signaling Pathway
Response To Growth Hormone
Response To Exogenous DsRNA
Leukocyte Migration
Negative Regulation Of Formation Of Translation Preinitiation Complex
Positive Regulation Of Luteinizing Hormone Secretion
Negative Regulation Of Glutamine Transport
Negative Regulation Of Apolipoprotein Binding
Cellular Response To L-ascorbic Acid
Toll-like Receptor 5 Signaling Pathway
Viral Process
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Regulation Of Body Fluid Levels
Toll-like Receptor 9 Signaling Pathway
Tagcloud
?
antibiotic
appropriate
children
chosen
circulating
cutoff
detectable
febrile
fell
fever
greatly
helpful
il
involving
lasting
necrosis
none
pediatric
pg
pneumonia
probable
rather
remained
sequential
syndrome
tnf
tool
uti
viral
Tagcloud (Difference)
?
antibiotic
appropriate
children
chosen
circulating
cutoff
detectable
febrile
fell
fever
greatly
helpful
il
involving
lasting
necrosis
none
pediatric
pg
pneumonia
probable
rather
remained
sequential
syndrome
tnf
tool
uti
viral
Tagcloud (Intersection)
?