PEX7 and STOML2

Data Source: HiPPIP (Novel)

		PEX7	STOML2
Name		peroxisomal biogenesis factor 7	stomatin like 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol	Immunological Synapse Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Membrane Raft
	Molecular Function	Peroxisome Matrix Targeting Signal-2 Binding Protein Binding Enzyme Binding Protein Homodimerization Activity	Protein Binding Lipid Binding T Cell Receptor Binding GTPase Binding Cardiolipin Binding
	Biological Process	Neuron Migration Endochondral Ossification Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Peroxisome Organization Ether Lipid Biosynthetic Process Protein Transport Protein Import Into Peroxisome Matrix	Intracellular Calcium Ion Homeostasis Mitochondrion Organization Lipid Localization Positive Regulation Of Interleukin-2 Production Mitochondrial Protein Processing CD4-positive, Alpha-beta T Cell Activation Proton Motive Force-driven Mitochondrial ATP Synthesis T Cell Receptor Signaling Pathway Protein Complex Oligomerization Stress-induced Mitochondrial Fusion
Pathways		Peroxisomal protein import Peroxisomal protein import	Processing of SMDT1 Cellular response to mitochondrial stress
Diseases		Refsum disease; Heredopathia atactica polyneuritiformis Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)	None
GWAS		Caffeine consumption from coffee or tea ( 33287642 ) Caffeine consumption from tea ( 33287642 ) Lymphocyte percentage of white cells ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil percentage of white cells ( 32888494 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: STOML2	10 novel interactors: ACOT11 CDH1 HSF4 LNX1 MCC PEX7 RFXANK RNF38 RPS7 TAL1
Interacting Genes		8 interacting genes: ACAT1 KDM1A PEX13 PEX14 PEX5 PEX5L PHYH PRMT6	5 interacting genes: APP GLP1R OGT RABAC1 SUMO4
Entrez ID		5191	30968
HPRD ID		03454	16310
Ensembl ID		ENSG00000112357	ENSG00000165283
Uniprot IDs		A0A7I2V2J8 O00628 Q6FGN1	A0A087WYB4 Q9UJZ1
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Substrate Release Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Peroxisomal Membrane Protein Import Into Peroxisome Matrix Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Organization Receptor Recycling Peroxisome Intracellular Protein Transmembrane Transport Lipid Modification Peroxisomal Importomer Complex Peroxisome Targeting Sequence Binding Receptor Metabolic Process Protein Monoubiquitination Carboxylic Acid Catabolic Process Fatty Acid Alpha-oxidation Lipid Catabolic Process Protein Transmembrane Transport Fatty Acid Metabolic Process Cellular Response To Reactive Oxygen Species Small Molecule Metabolic Process Protein-containing Complex Disassembly Monocarboxylic Acid Metabolic Process Response To Reactive Oxygen Species Protein Transmembrane Transporter Activity Cerebral Cortex Cell Migration Cellular Response To Oxidative Stress Telencephalon Cell Migration Forebrain Cell Migration Carboxylic Acid Metabolic Process Cellular Response To Chemical Stress Peroxisomal Matrix Organic Acid Metabolic Process Fatty Acid Beta-oxidation Metanephric Proximal Convoluted Tubule Development Propionyl-CoA Biosynthetic Process C-acetyltransferase Activity Peroxisome Transport Along Microtubule 2-oxobutyrate Catabolic Process Phytanoyl-CoA Dioxygenase Activity Lipid Localization Histone H2AR3 Methyltransferase Activity	None