PHYH and FKBP4

Number of citations of the paper that reports this interaction (PubMedID 10051602)
42

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		PHYH	FKBP4
Description		phytanoyl-CoA 2-hydroxylase	FKBP prolyl isomerase 4
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GO Annotations	Cellular Component	Peroxisome Peroxisomal Matrix Cytosol 9+0 Non-motile Cilium	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Microtubule Axon Protein-containing Complex Cell Projection Neuronal Cell Body Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Catalytic Activity Protein Binding Ferrous Iron Binding Oxidoreductase Activity Carboxylic Acid Binding L-ascorbic Acid Binding Metal Ion Binding Phytanoyl-CoA Dioxygenase Activity Dioxygenase Activity	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding ATP Binding GTP Binding FK506 Binding Isomerase Activity Protein-macromolecule Adaptor Activity Heat Shock Protein Binding Copper-dependent Protein Binding Nuclear Glucocorticoid Receptor Binding Tau Protein Binding Phosphoprotein Binding
	Biological Process	Fatty Acid Alpha-oxidation 2-oxoglutarate Metabolic Process Fatty Acid Metabolic Process Isoprenoid Metabolic Process 2-oxobutyrate Catabolic Process Methyl-branched Fatty Acid Metabolic Process	Protein Folding Steroid Hormone Receptor Complex Assembly Copper Ion Transport Embryo Implantation Negative Regulation Of Neuron Projection Development Androgen Receptor Signaling Pathway Prostate Gland Development Negative Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Protein-containing Complex Localization Male Sex Differentiation Reproductive Structure Development
Pathways		Alpha-oxidation of phytanate Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS
Drugs		Antihemophilic factor, human recombinant Ascorbic acid Lonoctocog alfa Moroctocog alfa
Diseases		Refsum disease; Heredopathia atactica polyneuritiformis
GWAS			Apolipoprotein A1 levels ( 32203549) Estradiol levels ( 34255042) FEV1 ( 30804560) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Quantitative traits ( 19197348) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: ACSL6 APP F8 FAM9B FKBP4 MAGEA11 PATJ PEX7 PHYHIP SIRPA TOM1L1	24 interacting genes: ACVR1 AHSA1 ATOX1 CALM1 CEBPA CSNK2A1 EGFR ESR1 FES FKBP1A GLMN HSF1 HSPA4 IRF4 NR3C1 NR3C2 OGT PHYH PTPN2 S100A1 S100A2 S100A6 SH3BP4 SMURF2
Entrez ID		5264	2288
HPRD ID		03609	11794
Ensembl ID		ENSG00000107537	ENSG00000004478
Uniprot IDs		O14832	Q02790
PDB IDs		2A1X	1N1A 1P5Q 1Q1C 1QZ2 4DRJ 4LAV 4LAW 4LAX 4LAY 4TW8 6RCY 8FFV
Enriched GO Terms of Interacting Partners?			STAT Family Protein Binding Hsp90 Protein Binding Estrogen Response Element Binding Regulation Of Multicellular Organismal Process Signal Transduction ATPase Binding Cytosol Calcium-dependent Protein Binding Protein-containing Complex Regulation Of Cell Population Proliferation Embryonic Placenta Development TBP-class Protein Binding Steroid Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Identical Protein Binding Intracellular Signal Transduction Cellular Response To Estradiol Stimulus Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Hemopoiesis Positive Regulation Of Signal Transduction Sequence-specific DNA Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Response To Nutrient Nuclear Receptor Activity Regulation Of Gluconeogenesis Positive Regulation Of Fibroblast Proliferation Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Lipid Binding Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Regulation Of RNA Biosynthetic Process Regulation Of Protein Catabolic Process Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway S100 Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein Folding Response To Hormone
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