PHYH and F8

Number of citations of the paper that reports this interaction (PMID 11574539)
1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PHYH	F8
Gene Name		phytanoyl-CoA 2-hydroxylase	coagulation factor VIII, procoagulant component
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Matrix	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen
	Molecular Function	Protein Binding Electron Carrier Activity L-ascorbic Acid Binding Metal Ion Binding Cofactor Binding Phytanoyl-CoA Dioxygenase Activity	Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity
	Biological Process	Fatty Acid Alpha-oxidation Isoprenoid Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Methyl-branched Fatty Acid Metabolic Process	Platelet Degranulation Proteolysis Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation Oxidation-reduction Process
Pathways		Alpha-oxidation of phytanate Metabolism of lipids and lipoproteins Peroxisomal lipid metabolism	Common Pathway Intrinsic Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)
Drugs			Drotrecogin alfa Coagulation Factor IX
Diseases
GWAS			Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Red blood cell traits ( 23446634)
Protein-Protein Interactions		9 interactors: ACSL6 APP F8 FAM9B FKBP4 MAGEA11 PEX7 PHYHIP TOM1L1	16 interactors: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 UBQLN1 VWF
Entrez ID		5264	2157
HPRD ID		03609	02384
Ensembl ID		ENSG00000107537	ENSG00000185010
Uniprot IDs		O14832	P00451
PDB IDs		2A1X	1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV
Enriched GO Terms of Interacting Partners?		Transport Platelet Degranulation Regulation Of Neuron Differentiation Steroid Hormone Receptor Complex Assembly Positive Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Generation Of Neurons Neurogenesis Regulation Of Neurogenesis Synaptic Growth At Neuromuscular Junction Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Regulation Of Cell Development Negative Regulation Of Neuron Differentiation Platelet Activation Intracellular Receptor Signaling Pathway Nervous System Development Collateral Sprouting Axon Midline Choice Point Recognition Cellular Localization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Ether Lipid Biosynthetic Process Axon Choice Point Recognition Response To Abiotic Stimulus Negative Regulation Of Neurogenesis Neuron Remodeling Ether Lipid Metabolic Process Fatty Acid Metabolic Process Lipid Metabolic Process Negative Regulation Of Cell Development Exocytosis Positive Regulation Of Triglyceride Biosynthetic Process Response To Gravity Protein Import Into Peroxisome Matrix Negative Regulation Of Microtubule Polymerization Regulation Of Neuron Projection Development Long-chain Fatty-acyl-CoA Biosynthetic Process Blood Coagulation, Intrinsic Pathway Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Protein Autophosphorylation Regulation Of Mitotic Cell Cycle Intracellular Transport Blood Coagulation Protein Complex Localization Fatty-acyl-CoA Biosynthetic Process Cellular Copper Ion Homeostasis Hemostasis Regulation Of Cell Differentiation Cell Differentiation Response To Stress Positive Regulation Of Fatty Acid Transport	Post-translational Protein Modification Peptidyl-glutamic Acid Carboxylation Blood Coagulation Hemostasis Blood Coagulation, Intrinsic Pathway Regulation Of Body Fluid Levels Wound Healing Peptidyl-amino Acid Modification Vesicle-mediated Transport Response To Wounding Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Protein Metabolic Process Blood Coagulation, Extrinsic Pathway Protein Activation Cascade Negative Regulation Of Blood Coagulation Platelet Activation Negative Regulation Of Coagulation Glycoprotein Metabolic Process Negative Regulation Of Wound Healing Response To Stress Platelet Degranulation Regulation Of Blood Coagulation Protein Glycosylation Macromolecule Glycosylation Glycosylation Cellular Protein Modification Process Receptor-mediated Endocytosis Regulation Of Wound Healing Cellular Protein Metabolic Process Glycoprotein Biosynthetic Process Establishment Of Localization In Cell Response To Endoplasmic Reticulum Stress Fibrinolysis Secretion By Cell Proteolysis Transport Leukocyte Migration Cellular Localization Regulation Of Cell Migration Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Regulation Of Cell Motility Chaperone-mediated Protein Folding Secretion Peptide Antigen Assembly With MHC Class I Protein Complex Beta-amyloid Clearance Regulation Of Protein Folding In Endoplasmic Reticulum Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Endocytosis
Tagcloud ?		168phya asymmetric bacillus belonged bpp bpps crystallized di dii explaining glycol grew hcl histidine hjb17 incomplete p1211 phyht phyp phytases phytate polyethylene precipitant propeller refolding synchrotron trihydrate tris vapour	absent ba betac csf f3 gm gmr gmralpha gmrbeta granulocyte heterodimeric magnitude mitogenesis next phenylalanine phosphorylaiton proliferate prominent regenerate residues restored shc shp2 stat5 sufficient tyrosine y577 y612 y695
Tagcloud (Difference) ?		168phya asymmetric bacillus belonged bpp bpps crystallized di dii explaining glycol grew hcl histidine hjb17 incomplete p1211 phyht phyp phytases phytate polyethylene precipitant propeller refolding synchrotron trihydrate tris vapour	absent ba betac csf f3 gm gmr gmralpha gmrbeta granulocyte heterodimeric magnitude mitogenesis next phenylalanine phosphorylaiton proliferate prominent regenerate residues restored shc shp2 stat5 sufficient tyrosine y577 y612 y695
Tagcloud (Intersection) ?