PHYH and TOM1L1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PHYH	TOM1L1
Gene Name		phytanoyl-CoA 2-hydroxylase	target of myb1 (chicken)-like 1
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Matrix	Cytoplasm Lysosome Endosome Golgi Stack Cytosol Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Electron Carrier Activity L-ascorbic Acid Binding Metal Ion Binding Cofactor Binding Phytanoyl-CoA Dioxygenase Activity	Protein Binding SH3 Domain Binding Protein Kinase Binding Clathrin Binding Protein Kinase Activator Activity Ubiquitin Binding
	Biological Process	Fatty Acid Alpha-oxidation Isoprenoid Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Methyl-branched Fatty Acid Metabolic Process	Intracellular Protein Transport Signal Transduction Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process
Pathways		Alpha-oxidation of phytanate Metabolism of lipids and lipoproteins Peroxisomal lipid metabolism
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		9 interactors: ACSL6 APP F8 FAM9B FKBP4 MAGEA11 PEX7 PHYHIP TOM1L1	27 interactors: AMFR CCDC47 CELF1 COPS7A CWF19L1 FAM208A FYN GLUD2 GRB2 GSN HGS HNRNPH1 MAP3K3 NDC80 NOMO1 PDPN PELP1 PHYH PIK3R1 PWP2 RAB18 TOLLIP TSG101 TUBA1B UBXN4 VAV2 VCP
Entrez ID		5264	10040
HPRD ID		03609	05266
Ensembl ID		ENSG00000107537	ENSG00000141198
Uniprot IDs		O14832	B7Z9E2 I3L4I4 O75674
PDB IDs		2A1X	3RRU
Enriched GO Terms of Interacting Partners?		Transport Platelet Degranulation Regulation Of Neuron Differentiation Steroid Hormone Receptor Complex Assembly Positive Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Generation Of Neurons Neurogenesis Regulation Of Neurogenesis Synaptic Growth At Neuromuscular Junction Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Regulation Of Cell Development Negative Regulation Of Neuron Differentiation Platelet Activation Intracellular Receptor Signaling Pathway Nervous System Development Collateral Sprouting Axon Midline Choice Point Recognition Cellular Localization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Ether Lipid Biosynthetic Process Axon Choice Point Recognition Response To Abiotic Stimulus Negative Regulation Of Neurogenesis Neuron Remodeling Ether Lipid Metabolic Process Fatty Acid Metabolic Process Lipid Metabolic Process Negative Regulation Of Cell Development Exocytosis Positive Regulation Of Triglyceride Biosynthetic Process Response To Gravity Protein Import Into Peroxisome Matrix Negative Regulation Of Microtubule Polymerization Regulation Of Neuron Projection Development Long-chain Fatty-acyl-CoA Biosynthetic Process Blood Coagulation, Intrinsic Pathway Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Protein Autophosphorylation Regulation Of Mitotic Cell Cycle Intracellular Transport Blood Coagulation Protein Complex Localization Fatty-acyl-CoA Biosynthetic Process Cellular Copper Ion Homeostasis Hemostasis Regulation Of Cell Differentiation Cell Differentiation Response To Stress Positive Regulation Of Fatty Acid Transport	Phosphatidylinositol-mediated Signaling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Endoplasmic Reticulum Stress Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Platelet Activation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Neurotrophin TRK Receptor Signaling Pathway T Cell Costimulation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Response To Organic Substance Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of RNA Splicing Fc Receptor Signaling Pathway ER-nucleus Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Wound Healing Response To Unfolded Protein Response To Stress Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Component Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Complex Assembly Response To Wounding ER-associated Ubiquitin-dependent Protein Catabolic Process Blood Coagulation Hemostasis Cellular Response To Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Fibroblast Growth Factor Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination NFAT Protein Import Into Nucleus Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of ERBB Signaling Pathway Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of T Cell Activation
Tagcloud ?		168phya asymmetric bacillus belonged bpp bpps crystallized di dii explaining glycol grew hcl histidine hjb17 incomplete p1211 phyht phyp phytases phytate polyethylene precipitant propeller refolding synchrotron trihydrate tris vapour	adaptor behave bridged clathrin cytosolic defective egf egfr elusive endocytic endocytosis endosome engage exogenous grb2 incapable knocked machinery onto participate redistributes rescue rnai shc stimulates tail transient triggers tyr
Tagcloud (Difference) ?		168phya asymmetric bacillus belonged bpp bpps crystallized di dii explaining glycol grew hcl histidine hjb17 incomplete p1211 phyht phyp phytases phytate polyethylene precipitant propeller refolding synchrotron trihydrate tris vapour	adaptor behave bridged clathrin cytosolic defective egf egfr elusive endocytic endocytosis endosome engage exogenous grb2 incapable knocked machinery onto participate redistributes rescue rnai shc stimulates tail transient triggers tyr
Tagcloud (Intersection) ?