RIPOR2 and MAP2K2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RIPOR2	MAP2K2
Description		RHO family interacting cell polarization regulator 2	mitogen-activated protein kinase kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Apical Plasma Membrane Filopodium Stereocilium Cell Projection Stereocilium Membrane Actin-based Cell Projection	Extracellular Region Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Peroxisomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cell-cell Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding 14-3-3 Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Kinase Activity Transferase Activity PDZ Domain Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Molecular Adaptor Activity Scaffold Protein Binding Protein Serine Kinase Activity
	Biological Process	Chemotaxis Cell Adhesion Negative Regulation Of Cell Adhesion Muscle Organ Development Sensory Perception Of Sound Negative Regulation Of Signal Transduction Cell Differentiation Negative Regulation Of Rho Protein Signal Transduction Negative Regulation Of T Cell Proliferation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Filopodium Assembly Regulation Of Cell Cycle Positive Regulation Of Neutrophil Chemotaxis Regulation Of Mitotic Spindle Assembly Positive Regulation Of Myoblast Fusion Negative Regulation Of Establishment Of T Cell Polarity Negative Regulation Of Protein Localization To Cell Leading Edge Cellular Response To Chemokine Regulation Of Establishment Of Cell Polarity Positive Regulation Of Neutrophil Extravasation Negative Regulation Of T Cell Migration Negative Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity	MAPK Cascade Heart Development Positive Regulation Of Gene Expression Schwann Cell Development Thyroid Gland Development Regulation Of Stress-activated MAPK Cascade Peptidyl-serine Autophosphorylation ERBB2-ERBB3 Signaling Pathway Myelination Positive Regulation Of DNA-templated Transcription Insulin-like Growth Factor Receptor Signaling Pathway Thymus Development Regulation Of Axon Regeneration Positive Regulation Of Axonogenesis Face Development Lung Morphogenesis Trachea Formation Epithelial Cell Proliferation Involved In Lung Morphogenesis ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Positive Regulation Of Cell Motility Regulation Of Early Endosome To Late Endosome Transport
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	MAPK1 (ERK2) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants
Drugs			Bosutinib Trametinib Selumetinib Binimetinib Fostamatinib Pimasertib
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)	Eosinophil count ( 32888494) Heel bone mineral density ( 30598549) Height ( 29782485) Lymphocyte count ( 32888494) Pulse pressure ( 30224653) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: MAP2K2 MTNR1B PER1 RHOA RHOC YWHAG	20 interacting genes: ARAF BRAF CASP9 CCNDBP1 CNKSR1 COPS5 DUSP3 GRIN1 GRIN2D HNRNPK LAMTOR3 LIG4 MAPK1 MAPK3 MAPK8 MOS RAF1 RGS12 RIPOR2 ZNF207
Entrez ID		9750	5605
HPRD ID		12881	03164
Ensembl ID		ENSG00000111913	ENSG00000126934
Uniprot IDs		A0A2R8Y7B3 A0A2R8YEE0 B7Z5J9 B7Z6D6 B7Z6U4 F5GX51 F5H029 Q9Y4F9	B3KS97 P36507
PDB IDs			1S9I 4H3Q
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Satellite Cell Migration Positive Regulation Of Lipase Activity Apical Junction Assembly Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Wound Healing, Spreading Of Cells Regulation Of Protein Kinase Activity Regulation Of Cell Communication Regulation Of Kinase Activity Regulation Of Signaling Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Stress Fiber Assembly Cleavage Furrow Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Vasoconstriction Positive Regulation Of Actin Filament Bundle Assembly Mitotic Cytokinesis Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Focal Adhesion Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Cytoskeleton-dependent Cytokinesis Regulation Of Stress Fiber Assembly Regulation Of Phosphorus Metabolic Process Aortic Valve Formation Cell-cell Junction Assembly Positive Regulation Of Hydrolase Activity Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Cell Motility Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Positive Regulation Of Locomotion Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Circadian Rhythm Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Modification Process Beta Selection Protein Kinase C Inhibitor Activity Blood Vessel Diameter Maintenance	MAPK Cascade MAP Kinase Kinase Kinase Activity Face Development Thyroid Gland Development Intracellular Signal Transduction Protein Serine Kinase Activity ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Intracellular Signaling Cassette Protein Serine/threonine Kinase Activity Thymus Development Regulation Of Signal Transduction Regulation Of MAPK Cascade MAP Kinase Activity Pseudopodium Protein Kinase Activity Schwann Cell Development ERBB Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Peptidyl-serine Phosphorylation Stress-activated MAPK Cascade ERBB2 Signaling Pathway Regulation Of Intracellular Signal Transduction Stress-activated Protein Kinase Signaling Cascade Signal Transduction Kinase Activity Interleukin-34-mediated Signaling Pathway Hematopoietic Or Lymphoid Organ Development Regulation Of Peptidyl-serine Phosphorylation Cytoplasm Regulation Of Chromosome Organization Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Synaptic Transmission NMDA Glutamate Receptor Activity Glutamate Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Granulocyte Chemotaxis Response To Epidermal Growth Factor Negative Regulation Of Apoptotic Process ERK1 And ERK2 Cascade Long-term Synaptic Potentiation Protein Phosphorylation Negative Regulation Of Programmed Cell Death NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity
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