PEG3 and SIAH1

Number of citations of the paper that reports this interaction (PubMedID 10681424)
25

Data Source:
HPRD (in vivo, two hybrid)

		PEG3	SIAH1
Description		paternally expressed 3	siah E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Autophagosome	Nucleus Cytoplasm Early Endosome Cytosol Beta-catenin Destruction Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Zinc Ion Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Ubiquitination Cell Differentiation Protein Catabolic Process Protein Destabilization Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Canonical Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Urate levels in lean individuals ( 25811787)	Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Mean corpuscular hemoglobin ( 32888494) Waist circumference ( 28552196)
Interacting Genes		7 interacting genes: APP BRCA1 LIMS1 SIAH1 SIAH2 TRAF2 USP7	157 interacting genes: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 AXIN1 AXIN2 BAG1 BAG3 BAG4 BCL6 CACYBP CAPG CCDC198 CDC23 CDC34 CDK5R1 COPS5 DAB1 DAZAP2 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 H4C16 HCFC1 HIF1AN HIPK2 HIPK3 INHA IQCN ITSN1 KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIF1B KIF22 KIFC3 KLF10 LACTB2 LANCL2 LMNA M1AP MAB21L1 MAP3K5 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 NANOS2 NANOS3 NECTIN2 NELFA NHERF2 NOL6 NTAQ1 NUMB NUMBL OPRM1 OTUB2 PARD6B PCDH17 PEG10 PEG3 PFKM PHC1 PHC2 PIAS2 PIAS3 PIMREG PINK1 PKD1 POU2AF1 PRPF31 PRR20B PRR20C PRR20D PRR20E PTPMT1 PUF60 PYGB QRICH1 RAB33A RAB33B RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 RXRB SDCBP SFMBT2 SH3RF1 SLAIN1 SNCAIP SPATA4 SPATC1L SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 ZYX
Entrez ID		5178	6477
HPRD ID		03285	03736
Ensembl ID		ENSG00000198300	ENSG00000196470
Uniprot IDs		A0A3B3IRU6 Q9GZU2	Q8IUQ4
PDB IDs		4BHX	2A25 4C9Z 4CA1 4I7B 4I7C 4I7D 4X3G 5WZZ 8HEO 9G0L
Enriched GO Terms of Interacting Partners?		Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Post-translational Protein Modification Ubiquitin Protein Ligase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Ubiquitin Conjugating Enzyme Binding Regulation Of Programmed Cell Death Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Epigenetic Regulation Of Gene Expression Protein Modification Process Protein Metabolic Process Apoptotic Process Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Early Endosome Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Small Molecule Metabolic Process Programmed Cell Death Cell Death Tumor Necrosis Factor-mediated Signaling Pathway TORC1 Signaling Zinc Ion Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of RNA Metabolic Process Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Surface Receptor Signaling Pathway P53 Binding Protein Autoubiquitination TORC2 Complex Disassembly Metal Ion Binding	Nucleus Ubiquitin Conjugating Enzyme Activity Protein Binding Ubiquitin Protein Ligase Binding Nucleoplasm Cytoplasm Protein Modification By Small Protein Conjugation Protein Polyubiquitination Perinuclear Region Of Cytoplasm Microtubule Cytoskeleton Post-translational Protein Modification Identical Protein Binding Beta-catenin Destruction Complex Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Nuclear Body Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Nucleotide Binding Protein Ubiquitination Cell Death Microtubule-based Process Apoptotic Process SUMO Transferase Activity Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Programmed Cell Death Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process Microtubule Cytoskeleton Organization Microtubule Regulation Of Macromolecule Metabolic Process Microtubule Binding Organelle Organization Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Lateral Ventricle Development Astrocyte Projection Positive Regulation Of Post-translational Protein Modification Establishment Of Mitochondrion Localization UBC13-MMS2 Complex Neuroblast Division In Subventricular Zone Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Adenyl-nucleotide Exchange Factor Activity Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process
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