BABAM1

Description		BRISC and BRCA1 A complex member 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body BRCA1-A Complex BRISC Complex
	Molecular Function	Protein Binding Identical Protein Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Cell Division Hematopoietic Stem Cell Proliferation DNA Repair-dependent Chromatin Remodeling
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Epithelial ovarian cancer ( 25581431) Mitochondrial DNA copy number ( 30704525)
Novel Interacting Genes		1 novel interacting genes: GATAD2A
Interacting Genes		7 interacting genes: ABRAXAS1 AKT1 BABAM2 BRCA1 TERF2IP TRIM27 UBC
Entrez ID		29086
HPRD ID		13702
Ensembl ID		ENSG00000105393
Uniprot IDs		J3KQS6 Q9NWV8
PDB IDs		6H3C 8PVY 8PY2
Enriched GO Terms of Interacting Partners?		BRCA1-A Complex Positive Regulation Of DNA Metabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Mitotic G2/M Transition Checkpoint Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Repair Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Nuclear Ubiquitin Ligase Complex Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Damage Checkpoint Signaling Nucleoplasm Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Post-translational Protein Modification Regulation Of G2/M Transition Of Mitotic Cell Cycle Chromatin Organization Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Phase Transition Response To Radiation Positive Regulation Of DNA Repair Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein K6-linked Ubiquitination Positive Regulation Of Metabolic Process Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle Process DNA Metabolic Process Negative Regulation Of Cell Cycle Process Protein Polyubiquitination Male Germ Cell Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Cellular Response To Stress Protein Modification Process Nucleus Negative Regulation Of Cell Cycle
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