BABAM1 and BABAM2

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (two hybrid)

		BABAM1	BABAM2
Description		BRISC and BRCA1 A complex member 1	BRISC and BRCA1 A complex member 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body BRCA1-A Complex BRISC Complex	Nuclear Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol BRCA1-A Complex BRISC Complex
	Molecular Function	Protein Binding Identical Protein Binding	Peroxisome Targeting Sequence Binding Tumor Necrosis Factor Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Cell Division Hematopoietic Stem Cell Proliferation DNA Repair-dependent Chromatin Remodeling	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization Apoptotic Process DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Signal Transduction Response To Ionizing Radiation Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Cell Division Protein K63-linked Deubiquitination Cellular Response To Ionizing Radiation Regulation Of DNA Damage Checkpoint
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Epithelial ovarian cancer ( 25581431) Mitochondrial DNA copy number ( 30704525)	Blond vs. brown/black hair color ( 30531825) Estimated glomerular filtration rate ( 31152163) Intraocular pressure ( 29617998) Low density lipoprotein cholesterol levels ( 33339817) Urate levels ( 31578528) Uterine fibroids ( 31649266)
Interacting Genes		7 interacting genes: ABRAXAS1 AKT1 BABAM2 BRCA1 TERF2IP TRIM27 UBC	7 interacting genes: BABAM1 GFI1B NCOA3 PPDPF SUMO2 UBC UBE2D1
Entrez ID		29086	9577
HPRD ID		13702	08498
Ensembl ID		ENSG00000105393	ENSG00000158019
Uniprot IDs		J3KQS6 Q9NWV8	Q9NXR7
PDB IDs		6H3C 8PVY 8PY2	6H3C 6R8F 8PVY 8PY2
Enriched GO Terms of Interacting Partners?		BRCA1-A Complex Positive Regulation Of DNA Metabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Mitotic G2/M Transition Checkpoint Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Repair Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Nuclear Ubiquitin Ligase Complex Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Damage Checkpoint Signaling Nucleoplasm Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Post-translational Protein Modification Regulation Of G2/M Transition Of Mitotic Cell Cycle Chromatin Organization Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Phase Transition Response To Radiation Positive Regulation Of DNA Repair Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein K6-linked Ubiquitination Positive Regulation Of Metabolic Process Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle Process DNA Metabolic Process Negative Regulation Of Cell Cycle Process Protein Polyubiquitination Male Germ Cell Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Cellular Response To Stress Protein Modification Process Nucleus Negative Regulation Of Cell Cycle	Protein Tag Activity TORC1 Signaling Organelle Envelope
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