NLK and CHD7

Number of citations of the paper that reports this interaction (PMID 17952062)
111

Data Source:
BioGRID (biochemical, affinity chromatography technology, pull down)

		NLK	CHD7
Gene Name		nemo-like kinase	chromodomain helicase DNA binding protein 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding SH2 Domain Binding	DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding
	Biological Process	MAPK Cascade Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Serine Phosphorylation Of STAT3 Protein Intracellular Signal Transduction Protein Autophosphorylation	Skeletal System Development In Utero Embryonic Development Heart Morphogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated RRNA Processing Central Nervous System Development Adult Heart Development Sensory Perception Of Sound Adult Walking Behavior Blood Circulation Chromatin Modification Cranial Nerve Development Olfactory Nerve Development Olfactory Bulb Development T Cell Differentiation Female Genitalia Development Embryonic Hindlimb Morphogenesis Positive Regulation Of Multicellular Organism Growth Olfactory Behavior Inner Ear Morphogenesis Nose Development Semicircular Canal Morphogenesis Genitalia Development Artery Morphogenesis Regulation Of Neurogenesis Cognition Palate Development Retina Development In Camera-type Eye Regulation Of Growth Hormone Secretion Limb Development Face Development Epithelium Development
Pathways		Ca2+ pathway Signaling by Wnt beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Pulmonary function decline ( 22424883) Refractive error ( 23396134)
Protein-Protein Interactions		25 interactors: ASGR1 ATXN1 CHD7 CREBBP CUL1 FBXW5 FOXO4 GRN HIPK2 KRTAP10-3 KRTAP4-2 KRTAP5-6 KRTAP5-9 LEF1 MYB MYBL1 PPARG QRICH1 RCHY1 SDR16C5 SKP2 STAT3 STAT5A USP4 ZHX3	3 interactors: CTCF NLK PPARG
Entrez ID		51701	55636
HPRD ID		17637	10595
Ensembl ID		ENSG00000087095	ENSG00000171316
Uniprot IDs		Q9UBE8	Q6ZWF9 Q9P2D1
PDB IDs			2CKC 2V0E 2V0F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Leukocyte Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Hemopoiesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Immune System Development Radial Glial Cell Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Developmental Process Lymphocyte Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Anatomical Structure Development Modification-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Multicellular Organism Growth Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Catabolic Process Cellular Response To Oxygen Levels Organ Development Regulation Of Cell Cycle Cellular Response To Hormone Stimulus	Response To Metformin Response To Diuretic Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Pancreatic Stellate Cell Proliferation Regulation Of Molecular Function, Epigenetic Cellular Response To Vitamin E Regulation Of Cholesterol Transporter Activity Serine Phosphorylation Of STAT3 Protein Serine Phosphorylation Of STAT Protein Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Nucleosome Positioning Cellular Response To Hyperoxia Receptor Biosynthetic Process Negative Regulation Of Multicellular Organismal Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Maintenance Of DNA Methylation Negative Regulation Of Telomerase Activity Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Centromeric Sister Chromatid Cohesion Regulation Of Cellular Ketone Metabolic Process Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Acute Inflammatory Response Regulation Of Telomerase Activity Response To Low-density Lipoprotein Particle Positive Regulation Of Phagocytosis, Engulfment Cellular Response To Lithium Ion Positive Regulation Of Fatty Acid Oxidation White Fat Cell Differentiation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process Cellular Response To Prostaglandin Stimulus Regulation Of Sister Chromatid Cohesion Response To Prostaglandin E Response To Vitamin E Response To Lipoprotein Particle Positive Regulation Of Oligodendrocyte Differentiation Monocyte Differentiation Negative Regulation Of Lipid Storage Lipoprotein Transport RNA Metabolic Process Negative Regulation Of DNA Biosynthetic Process Response To Immobilization Stress Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Transcription Involved In Cell Fate Commitment
Tagcloud ?		adenomatosis apr asymmetric asymmetry caenorhabditis divisions evolutionarily fates heterochronic illuminate lin lineages lit opposing pharynx polarity polarizing polyposis pop postembryonic proceeds renewing robustly seam symmetric tcf timing transitions wingless	causes charge contributes dead embryos expand f53q f54s gestation inappropriately insight l25q lethality mdm2 mdmx p53 phenotypes regulators reminiscent remodeler surprisingly syndrome transactivation transcriptionally triggering typically unrestrained variant w26s
Tagcloud (Difference) ?		adenomatosis apr asymmetric asymmetry caenorhabditis divisions evolutionarily fates heterochronic illuminate lin lineages lit opposing pharynx polarity polarizing polyposis pop postembryonic proceeds renewing robustly seam symmetric tcf timing transitions wingless	causes charge contributes dead embryos expand f53q f54s gestation inappropriately insight l25q lethality mdm2 mdmx p53 phenotypes regulators reminiscent remodeler surprisingly syndrome transactivation transcriptionally triggering typically unrestrained variant w26s
Tagcloud (Intersection) ?