CHD7 and CTCF

Number of citations of the paper that reports this interaction (PMID 17603073)
7

Data Source:
BioGRID (unspecified method)

		CHD7	CTCF
Gene Name		chromodomain helicase DNA binding protein 7	CCCTC-binding factor (zinc finger protein)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Chromosome, Centromeric Region Condensed Chromosome Nucleus Nucleoplasm Nucleolus
	Molecular Function	DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Skeletal System Development In Utero Embryonic Development Heart Morphogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated RRNA Processing Central Nervous System Development Adult Heart Development Sensory Perception Of Sound Adult Walking Behavior Blood Circulation Chromatin Modification Cranial Nerve Development Olfactory Nerve Development Olfactory Bulb Development T Cell Differentiation Female Genitalia Development Embryonic Hindlimb Morphogenesis Positive Regulation Of Multicellular Organism Growth Olfactory Behavior Inner Ear Morphogenesis Nose Development Semicircular Canal Morphogenesis Genitalia Development Artery Morphogenesis Regulation Of Neurogenesis Cognition Palate Development Retina Development In Camera-type Eye Regulation Of Growth Hormone Secretion Limb Development Face Development Epithelium Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Chromosome Segregation Maintenance Of DNA Methylation Positive Regulation Of Gene Expression Chromatin Modification Nucleosome Positioning Regulation Of Histone Methylation Regulation Of Histone Acetylation Regulation Of Gene Expression, Epigenetic Regulation Of Molecular Function, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Centromeric Sister Chromatid Cohesion
Pathways
Drugs
Diseases
GWAS		Pulmonary function decline ( 22424883) Refractive error ( 23396134)	HDL cholesterol ( 19060911)
Protein-Protein Interactions		3 interactors: CTCF NLK PPARG	13 interactors: CHD7 CHD8 HMGB1 POLR2A RXRA SIN3A SMAD3 SMAD4 SUZ12 THRB TRB YBX1 ZMYM4
Entrez ID		55636	10664
HPRD ID		10595	05005
Ensembl ID		ENSG00000171316	ENSG00000102974
Uniprot IDs		Q6ZWF9 Q9P2D1	P49711
PDB IDs		2CKC 2V0E 2V0F	1X6H 2CT1
Enriched GO Terms of Interacting Partners?		Response To Metformin Response To Diuretic Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Pancreatic Stellate Cell Proliferation Regulation Of Molecular Function, Epigenetic Cellular Response To Vitamin E Regulation Of Cholesterol Transporter Activity Serine Phosphorylation Of STAT3 Protein Serine Phosphorylation Of STAT Protein Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Nucleosome Positioning Cellular Response To Hyperoxia Receptor Biosynthetic Process Negative Regulation Of Multicellular Organismal Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Maintenance Of DNA Methylation Negative Regulation Of Telomerase Activity Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Centromeric Sister Chromatid Cohesion Regulation Of Cellular Ketone Metabolic Process Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Acute Inflammatory Response Regulation Of Telomerase Activity Response To Low-density Lipoprotein Particle Positive Regulation Of Phagocytosis, Engulfment Cellular Response To Lithium Ion Positive Regulation Of Fatty Acid Oxidation White Fat Cell Differentiation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process Cellular Response To Prostaglandin Stimulus Regulation Of Sister Chromatid Cohesion Response To Prostaglandin E Response To Vitamin E Response To Lipoprotein Particle Positive Regulation Of Oligodendrocyte Differentiation Monocyte Differentiation Negative Regulation Of Lipid Storage Lipoprotein Transport RNA Metabolic Process Negative Regulation Of DNA Biosynthetic Process Response To Immobilization Stress Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Transcription Involved In Cell Fate Commitment	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process In Utero Embryonic Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Embryo Development Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Developmental Process Nitrogen Compound Metabolic Process Heart Morphogenesis Positive Regulation Of Metabolic Process Multicellular Organismal Development Biosynthetic Process SMAD Protein Complex Assembly Regulation Of Binding Anatomical Structure Development Chromatin Modification Regulation Of Transforming Growth Factor Beta2 Production Tube Development Chromatin Organization
Tagcloud ?		causes charge contributes dead embryos expand f53q f54s gestation inappropriately insight l25q lethality mdm2 mdmx p53 phenotypes regulators reminiscent remodeler surprisingly syndrome transactivation transcriptionally triggering typically unrestrained variant w26s	acting angle bend bending binds chicken confer direction efficiently erba f1 f2 fails flexure hetero heterodimer homodimer homologue lysozyme magnitude nep1 quaternary represses rxr silencer simultaneously synergistically t3 tr
Tagcloud (Difference) ?		causes charge contributes dead embryos expand f53q f54s gestation inappropriately insight l25q lethality mdm2 mdmx p53 phenotypes regulators reminiscent remodeler surprisingly syndrome transactivation transcriptionally triggering typically unrestrained variant w26s	acting angle bend bending binds chicken confer direction efficiently erba f1 f2 fails flexure hetero heterodimer homodimer homologue lysozyme magnitude nep1 quaternary represses rxr silencer simultaneously synergistically t3 tr
Tagcloud (Intersection) ?