CHD7

Description		chromodomain helicase DNA binding protein 7
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding ATP-dependent Chromatin Remodeler Activity Promoter-specific Chromatin Binding
	Biological Process	Skeletal System Development Blood Vessel Development In Utero Embryonic Development Blood Vessel Remodeling Heart Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Right Ventricular Compact Myocardium Morphogenesis Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription RRNA Processing Transcription By RNA Polymerase II Central Nervous System Development Adult Heart Development Sensory Perception Of Sound Locomotory Behavior Adult Walking Behavior Blood Circulation Response To Bacterium Regulation Of Gene Expression Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cranial Nerve Development Olfactory Nerve Development Olfactory Bulb Development T Cell Differentiation Female Genitalia Development Embryonic Hindlimb Morphogenesis Aorta Development Aorta Morphogenesis Atrioventricular Canal Development Positive Regulation Of Multicellular Organism Growth Olfactory Behavior Ear Morphogenesis Inner Ear Morphogenesis Chordate Embryonic Development Camera-type Eye Development Nose Development Positive Regulation Of Transcription By RNA Polymerase II Semicircular Canal Morphogenesis Tissue Remodeling Genitalia Development Artery Morphogenesis Regulation Of Neurogenesis Nervous System Process Cognition Regulation Of Transport Roof Of Mouth Development Retina Development In Camera-type Eye Regulation Of Growth Hormone Secretion Limb Development Head Development Face Development Innervation Cardiac Septum Morphogenesis Epithelium Development Secondary Palate Development
Pathways
Drugs
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL) CHARGE syndrome
GWAS		Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Eosinophil count ( 32888494 27863252 29403010) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 28552196) Lymphocyte percentage of white cells ( 27863252 32888494) Menopause (age at onset) ( 26414677) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 29403010 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Pulmonary function decline ( 22424883) Refractive error ( 32231278 23396134) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic sclerosis ( 31672989) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532) White blood cell count ( 29403010 27863252 32888494)
Novel Interacting Genes		1 novel interacting genes: GGH
Interacting Genes		3 interacting genes: CHD8 CTCF TSG101
Entrez ID		55636
HPRD ID		10595
Ensembl ID		ENSG00000171316
Uniprot IDs		Q6ZWF9 Q9P2D1
PDB IDs		2CKC 2V0E 2V0F
Enriched GO Terms of Interacting Partners?		Exosomal Secretion Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Extracellular Exosome Assembly Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Viral Budding Via Host ESCRT Complex Exopeptidase Activity Gamma-glutamyl-peptidase Activity Omega Peptidase Activity Tetrahydrofolylpolyglutamate Metabolic Process Chromatin Insulator Sequence Binding Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chromatin Loop Anchoring Activity Regulation Of Centromeric Sister Chromatid Cohesion Chordate Embryonic Development In Utero Embryonic Development Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Fibroblast Apoptotic Process Virion Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process ESCRT I Complex Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity Prepulse Inhibition Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Vacuole Chromatin Binding Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Sister Chromatid Cohesion Chromatin Looping Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Fibroblast Apoptotic Process ATP-dependent Chromatin Remodeler Activity Startle Response Viral Budding Via Host ESCRT Complex Regulation Of Protein Tyrosine Kinase Activity Genomic Imprinting Histone H3K4me3 Reader Activity Positive Regulation Of Viral Life Cycle Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Flemming Body Regulation Of Signaling Receptor Activity Negative Regulation Of Macromolecule Biosynthetic Process Protein Localization To Organelle
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