XPO7 and NUP153

Number of citations: 0 (PubMedID 11024021)
Data Source: HPRD (in vitro)

		XPO7	NUP153
Name		exportin 7	nucleoporin 153
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Pore Cytoplasm	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytosol Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Host Cell Nuclear Pore Nuclear Basket
	Molecular Function	Nuclear Export Signal Receptor Activity Protein Binding Small GTPase Binding	DNA Binding Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-membrane Adaptor Activity Metal Ion Binding Molecular Condensate Scaffold Activity
	Biological Process	Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Protein Transport Nuclear Transport	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport Symbiont Entry Into Host Cell Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Pore Complex Assembly Viral Penetration Into Host Nucleus Amyloid Fibril Formation
Pathways		None	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
GWAS		Atrial fibrillation ( 30061737 29892015 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Lung cancer in ever smokers ( 28604730 ) Maximum habitual alcohol consumption ( 31151762 ) Mean corpuscular hemoglobin ( 28017375 29403010 27863252 32888494 ) Mean corpuscular volume ( 27863252 29403010 20139978 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Platelet distribution width ( 32888494 ) PR interval ( 32439900 ) Red blood cell count ( 27863252 32888494 ) Refractive error ( 32231278 )	Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 18391951 ) Obesity-related traits ( 23251661 )
Novel Interactors		1 novel interactors: ATXN1	2 novel interactors: DTNBP1 MRPS5
Interacting Genes		9 interacting genes: DDX19B MAPK9 NUP153 PDPK1 RAN RNF10 TAB1 USO1 XPOT	29 interacting genes: APC BRCA1 CEBPA CLK1 DNMT3A DYNLT1 FILNC1 GRSF1 IPO5 KPNA2 KPNB1 MAPK1 MAPK14 MAPK3 NUP62 NXF1 NXF2 PTGER4 RAN SENP2 SMAD2 SMAD3 TNPO1 TPR TRN-GTT2-7 XPO1 XPO5 XPO7 XPOT
Entrez ID		23039	9972
HPRD ID		05846	04899
Ensembl ID		ENSG00000130227	ENSG00000124789
Uniprot IDs		Q9UIA9	P49790
PDB IDs		Not available	2EBQ 2EBR 2EBV 2GQE 4U0C 4U0D 5TSV 5TSX 6AYA 8CKY 8CL0 9CNU
GO Terms Enriched among Interactors		Nuclear Export RNA Export From Nucleus Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore Intracellular Transport RNA Transport Cellular Localization Nucleobase-containing Compound Transport Establishment Of Localization In Cell Intracellular Protein Transport Nuclear Inclusion Body Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Protein Localization Protein Transport Nuclear Envelope Regulation Of Glial Cell Proliferation Establishment Of Protein Localization 3-phosphoinositide-dependent Protein Kinase Activity Golgi Vesicle Docking TRNA Re-export From Nucleus RNA Binding Intracellular Signaling Cassette Protein Localization To Tricellular Tight Junction RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Positive Regulation Of Multicellular Organismal Process Regulation Of Gliogenesis JUN Kinase Activity TRNA Export From Nucleus Cytoplasm Cytosol Regulation Of Nucleocytoplasmic Transport Import Into Nucleus Protein Import Into Nucleus RNA Import Into Nucleus POZ Domain Binding Negative Regulation Of RNA Export From Nucleus Viral Penetration Into Host Nucleus MRNA Transport Nuclear Matrix Regulation Of Cellular Localization Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Viral Process Ribosomal Large Subunit Export From Nucleus TRNA Transport	Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore RNA Transport Nuclear Export RNA Export From Nucleus Nucleobase-containing Compound Transport Protein Transport Establishment Of Protein Localization Regulation Of Intracellular Transport Protein Localization To Nucleus Intracellular Protein Transport Protein Import Into Nucleus Nucleoplasm Import Into Nucleus Protein Export From Nucleus Intracellular Transport Nuclear Export Signal Receptor Activity Positive Regulation Of Protein Import Into Nucleus Intracellular Protein Localization Establishment Of Localization In Cell RNA Import Into Nucleus Nuclear Import Signal Receptor Activity Regulation Of Nucleocytoplasmic Transport Nuclear Localization Sequence Binding Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Nuclear Envelope MRNA Transport RNA Binding Cellular Localization Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Regulation Of Cellular Localization Nuclear Membrane Positive Regulation Of Intracellular Protein Transport Small GTPase Binding Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Localization To Nucleus Nucleus Establishment Of Protein Localization To Organelle Phosphatase Binding Response To Tumor Necrosis Factor Regulation Of Ossification MAP Kinase Activity RNA Nuclear Export Complex Pre-miRNA Export From Nucleus Regulation Of Cytoskeleton Organization MRNA Export From Nucleus Cytoplasm