NSG2 and UCHL3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		NSG2	UCHL3
Description		neuronal vesicle trafficking associated 2	ubiquitin C-terminal hydrolase L3
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Late Endosome Golgi Apparatus Endosome Membrane Membrane Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Golgi Cisterna Membrane Multivesicular Body Membrane Trans-Golgi Network Membrane Cell Projection Lysosomal Lumen Postsynaptic Density Membrane Glutamatergic Synapse Golgi Cis Cisterna Membrane	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Protein Binding Clathrin Light Chain Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Ubiquitin Binding Deubiquitinase Activity
	Biological Process	Endosomal Transport Clathrin Coat Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Catabolic Process Post-translational Protein Modification
Pathways			UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation
Drugs
Diseases
GWAS		Alzheimer's disease ( 33074286) Blond vs. brown/black hair color ( 30531825) Diffusing capacity of carbon monoxide ( 30694715) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: ANKRD46 APOC1 C3orf52 CLEC7A HCFC1R1 NDUFA2 RIF1 RPS27 RRH SERPINH1 SLC35F6 STX18 SUPT4H1 TNNT1 TSPAN6 UCHL3 ZNF768	23 interacting genes: ATM ATXN7L3 CCNB1 CDH1 CEBPA FOXM1 LONRF1 NEDD8 NSG2 PJA1 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5 YAP1
Entrez ID		51617	7347
HPRD ID		13664	04367
Ensembl ID		ENSG00000170091	ENSG00000118939
Uniprot IDs		Q9Y328	A0A140VJZ4 P15374
PDB IDs			1UCH 1XD3 6ISU 6QML 7YV4
Enriched GO Terms of Interacting Partners?			Cellular Response To Gamma Radiation Post-translational Protein Modification Response To Gamma Radiation Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Protein K63-linked Ubiquitination Cellular Response To Ionizing Radiation Protein Ubiquitination Response To Stress Cellular Response To Camptothecin Regulation Of Primary Metabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Metal Ion Ubiquitin Protein Ligase Activity Cellular Response To Oxygen-containing Compound Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Lithium Ion Nucleoplasm Interleukin-6-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Lithium Ion Cysteine-type Deubiquitinase Activity Regulation Of DNA Repair Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Protein Deubiquitination Telomere Maintenance Signal Transduction By P53 Class Mediator Response To Toxic Substance Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein-containing Complex Organization Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Gland Development Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Deubiquitinase Activity Protein Polyubiquitination Protein Modification By Small Protein Removal DNA Damage Response
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