ERGIC3 and ATP6V0C

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		ERGIC3	ATP6V0C
Description		ERGIC and golgi 3	ATPase H+ transporting V0 subunit c
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Retrograde Transporter Complex, Golgi To ER Transporter Complex	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain Azurophil Granule Membrane Synapse Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding	Protein Binding Proton Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Vesicle-mediated Transport Positive Regulation Of Intracellular Protein Transport	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Proton Motive Force-driven ATP Synthesis Regulation Of Macroautophagy Positive Regulation Of Wnt Signaling Pathway Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs			Tiludronic acid
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 24097068 25961943 20686565) Height ( 28552196) Hip circumference adjusted for BMI ( 28552196 34021172) LDL cholesterol levels ( 32203549) Refractive error ( 32231278) Schizophrenia ( 28991256) Total cholesterol levels ( 28334899 30275531) Triglycerides ( 25961943) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		233 interacting genes: ABHD16A ADGRE2 ADIPOQ AGPAT4 AGTRAP AIG1 ALG10 AOC2 APOC3 APOD APOL2 AQP10 AQP2 AQP3 ARLN ASGR1 ATP13A1 ATP1B4 ATP6V0C BCL2L1 BET1 BIK BNIP3 BTN2A2 BUD31 C14orf180 C2 C3orf52 CCDC167 CCR2 CCR4 CCR8 CD207 CD302 CD81 CDIPT CDS2 CEBPA CFHR5 CHRM4 CIAO2A CLCA4 CLDN19 CLDN8 CLDND2 CMTM5 CNIH1 CNIH3 COL4A5 COX20 CTSA CTXN3 CXorf66 CYB561 CYB561D2 CYB5B CYBC1 CYP4F2 DEFB103A DEFB103B EBP EMC6 EMP1 EMP3 ENTPD3 ERG28 ERGIC1 EXTL1 F2RL1 FA2H FAM3C FAXDC2 FETUB FIS1 FKBP8 FUNDC2 FXYD2 FXYD3 FXYD6 FXYD6-FXYD2 GAST GIMAP1 GIMAP5 GJB2 GOSR2 GPM6B GPR151 GPR152 GPR35 GPR37 GYPA HHATL HMOX1 HMOX2 IFITM3 IGFBP5 INSIG2 ITGAM JAGN1 KCNK1 LHFPL5 LPAR3 LPCAT2 MALL MARCHF2 MARCHF5 MFF MFSD6 MIP MS4A13 MYADM NDRG4 NDUFB6 NEU1 NINJ2 NKG7 NRG4 NRM NSG1 OGT ORMDL1 ORMDL2 ORMDL3 PAQR5 PAQR7 PEX11G PEX16 PGAP2 PLLP PLN PLP1 PLPP4 PMP22 PNLIPRP1 POMGNT1 RFT1 RHAG RTP2 RUSF1 SCARB2 SCD SEC22B SEC23A SELENOK SERP2 SFXN5 SLC13A3 SLC1A1 SLC29A2 SLC30A2 SLC35A1 SLC35A4 SLC35B2 SLC35B4 SLC38A7 SLC41A1 SLC41A2 SLC49A3 SMAGP SMCO4 SMIM1 SMIM3 SNCA SNORC SPN STATH STRIT1 STX12 STX1B STX3 STX8 SYNGR1 SYNJ2BP SYS1 TAP1 TECR TF THBD TM4SF4 TMEM100 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM140 TMEM141 TMEM147 TMEM14A TMEM14B TMEM179B TMEM203 TMEM218 TMEM222 TMEM229B TMEM243 TMEM254 TMEM42 TMEM60 TMEM65 TMEM86A TMEM86B TMEM97 TMUB2 TNFRSF10C TOMM6 TRAM1L1 TRARG1 TREX1 TRIM32 TSPAN33 TSPO2 UBIAD1 UNC50 UNC93B1 UPK1B VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VKORC1L1 VMP1 VSTM1 VTI1B YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC15 ZDHHC21 ZFPL1	54 interacting genes: AQP6 ARF6 ASGR2 CD53 CD69 CD79A CERS2 CLEC14A CLEC17A CLEC2D CLIC1 CPLX4 CREB3 DNAJC1 DRD2 EDA EDA2R ERBB2 ERGIC3 ERH EVI2A FAM210B FFAR2 GPR152 GPR25 GPR42 HSD17B13 HTR2C KLRC1 LMNA LRRC25 MARK3 MCEMP1 MDFI MSR1 NIPAL3 OPRM1 PDCD1LG2 PI16 PSMA3 RETREG3 SCN3B SLC35E3 SLC7A1 SMIM3 SPACA1 SSMEM1 STOM SUSD3 TMEM139 TMEM31 TMEM9 VSIR ZCCHC12
Entrez ID		51614	527
HPRD ID		15306	00162
Ensembl ID		ENSG00000125991	ENSG00000185883
Uniprot IDs		A2TJK5 Q9Y282	P27449
PDB IDs			6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Plasma Membrane Establishment Of Protein Localization To Membrane Endomembrane System Vesicle Fusion Golgi Membrane Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Localization Within Membrane Chemical Homeostasis Membrane Fusion Protein Localization To Membrane Membrane Organization SNARE Complex Assembly Protein Localization To Cell Periphery Establishment Of Protein Localization Establishment Of Protein Localization To Plasma Membrane Mitochondrial Outer Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Transmembrane Transport SNARE Binding Cellular Localization Membrane Docking Cholesterol Binding Bleb Assembly Structural Constituent Of Myelin Sheath Vesicle Organization Organelle Localization By Membrane Tethering Transport Vesicle Protein Localization To Plasma Membrane Intracellular Chemical Homeostasis Vesicle-mediated Transport To The Plasma Membrane Vesicle Docking Golgi Apparatus Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Homeostatic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Water Channel Activity Endosome To Plasma Membrane Protein Transport Golgi Vesicle Transport Mitochondrial Membrane Myelination Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity	Membrane Protein Binding Plasma Membrane Transmembrane Signaling Receptor Activity External Side Of Plasma Membrane Carbohydrate Binding G Protein-coupled Receptor Activity Fucose Binding Regulation Of Establishment Of Protein Localization Identical Protein Binding
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