ERGIC3 and GPR35

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		ERGIC3	GPR35
Description		ERGIC and golgi 3	G protein-coupled receptor 35
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Retrograde Transporter Complex, Golgi To ER Transporter Complex	Plasma Membrane Membrane
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-X-C Chemokine Receptor Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Vesicle-mediated Transport Positive Regulation Of Intracellular Protein Transport	Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways			Class A/1 (Rhodopsin-like receptors)
Drugs			Furosemide Pyrantel Kynurenic Acid
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 24097068 25961943 20686565) Height ( 28552196) Hip circumference adjusted for BMI ( 28552196 34021172) LDL cholesterol levels ( 32203549) Refractive error ( 32231278) Schizophrenia ( 28991256) Total cholesterol levels ( 28334899 30275531) Triglycerides ( 25961943) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 21297633 28067908)
Interacting Genes		233 interacting genes: ABHD16A ADGRE2 ADIPOQ AGPAT4 AGTRAP AIG1 ALG10 AOC2 APOC3 APOD APOL2 AQP10 AQP2 AQP3 ARLN ASGR1 ATP13A1 ATP1B4 ATP6V0C BCL2L1 BET1 BIK BNIP3 BTN2A2 BUD31 C14orf180 C2 C3orf52 CCDC167 CCR2 CCR4 CCR8 CD207 CD302 CD81 CDIPT CDS2 CEBPA CFHR5 CHRM4 CIAO2A CLCA4 CLDN19 CLDN8 CLDND2 CMTM5 CNIH1 CNIH3 COL4A5 COX20 CTSA CTXN3 CXorf66 CYB561 CYB561D2 CYB5B CYBC1 CYP4F2 DEFB103A DEFB103B EBP EMC6 EMP1 EMP3 ENTPD3 ERG28 ERGIC1 EXTL1 F2RL1 FA2H FAM3C FAXDC2 FETUB FIS1 FKBP8 FUNDC2 FXYD2 FXYD3 FXYD6 FXYD6-FXYD2 GAST GIMAP1 GIMAP5 GJB2 GOSR2 GPM6B GPR151 GPR152 GPR35 GPR37 GYPA HHATL HMOX1 HMOX2 IFITM3 IGFBP5 INSIG2 ITGAM JAGN1 KCNK1 LHFPL5 LPAR3 LPCAT2 MALL MARCHF2 MARCHF5 MFF MFSD6 MIP MS4A13 MYADM NDRG4 NDUFB6 NEU1 NINJ2 NKG7 NRG4 NRM NSG1 OGT ORMDL1 ORMDL2 ORMDL3 PAQR5 PAQR7 PEX11G PEX16 PGAP2 PLLP PLN PLP1 PLPP4 PMP22 PNLIPRP1 POMGNT1 RFT1 RHAG RTP2 RUSF1 SCARB2 SCD SEC22B SEC23A SELENOK SERP2 SFXN5 SLC13A3 SLC1A1 SLC29A2 SLC30A2 SLC35A1 SLC35A4 SLC35B2 SLC35B4 SLC38A7 SLC41A1 SLC41A2 SLC49A3 SMAGP SMCO4 SMIM1 SMIM3 SNCA SNORC SPN STATH STRIT1 STX12 STX1B STX3 STX8 SYNGR1 SYNJ2BP SYS1 TAP1 TECR TF THBD TM4SF4 TMEM100 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM140 TMEM141 TMEM147 TMEM14A TMEM14B TMEM179B TMEM203 TMEM218 TMEM222 TMEM229B TMEM243 TMEM254 TMEM42 TMEM60 TMEM65 TMEM86A TMEM86B TMEM97 TMUB2 TNFRSF10C TOMM6 TRAM1L1 TRARG1 TREX1 TRIM32 TSPAN33 TSPO2 UBIAD1 UNC50 UNC93B1 UPK1B VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VKORC1L1 VMP1 VSTM1 VTI1B YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC15 ZDHHC21 ZFPL1	58 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1
Entrez ID		51614	2859
HPRD ID		15306	16003
Ensembl ID		ENSG00000125991	ENSG00000178623
Uniprot IDs		A2TJK5 Q9Y282	A8K2J1 B2RA17 Q9HC97
PDB IDs			8H8J
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Plasma Membrane Establishment Of Protein Localization To Membrane Endomembrane System Vesicle Fusion Golgi Membrane Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Localization Within Membrane Chemical Homeostasis Membrane Fusion Protein Localization To Membrane Membrane Organization SNARE Complex Assembly Protein Localization To Cell Periphery Establishment Of Protein Localization Establishment Of Protein Localization To Plasma Membrane Mitochondrial Outer Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Transmembrane Transport SNARE Binding Cellular Localization Membrane Docking Cholesterol Binding Bleb Assembly Structural Constituent Of Myelin Sheath Vesicle Organization Organelle Localization By Membrane Tethering Transport Vesicle Protein Localization To Plasma Membrane Intracellular Chemical Homeostasis Vesicle-mediated Transport To The Plasma Membrane Vesicle Docking Golgi Apparatus Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Homeostatic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Water Channel Activity Endosome To Plasma Membrane Protein Transport Golgi Vesicle Transport Mitochondrial Membrane Myelination Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Membrane Inorganic Ion Transmembrane Transport Transmembrane Transport Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transport Monoatomic Ion Transport Membrane Organization Cholesterol Metabolic Process Metal Ion Transport Sterol Metabolic Process Inorganic Cation Transmembrane Transport Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transmembrane Transport Import Across Plasma Membrane Sterol Biosynthetic Process Positive Regulation Of Protein Localization Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Cytoplasmic Vesicle Membrane Plasma Membrane Lysosome Glucose 6-phosphate:phosphate Antiporter Activity C-4 Methylsterol Oxidase Activity Lysosomal Membrane Import Into Cell Monoatomic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Intracellular Monoatomic Ion Homeostasis Vesicle-mediated Transport Recycling Endosome Glucose-6-phosphate Transport Phagocytic Cup Carbohydrate Derivative Transport Steroid Metabolic Process Potassium Ion Transmembrane Transport Endoplasmic Reticulum Tubular Network Formation Late Endosome Membrane Monoatomic Cation Homeostasis Regulation Of Protein Localization Steroid Biosynthetic Process Monoatomic Ion Homeostasis Postsynaptic Density Proton Transmembrane Transport Cholesterol Biosynthetic Process Positive Regulation Of Intracellular Protein Transport
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