ERGIC3 and FKBP8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ERGIC3	FKBP8
Description		ERGIC and golgi 3	FKBP prolyl isomerase 8
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Retrograde Transporter Complex, Golgi To ER Transporter Complex	Mitochondrion Mitochondrial Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane Mitochondrial Membrane Protein-containing Complex
	Molecular Function	Protein Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Calmodulin Binding Isomerase Activity Identical Protein Binding Protein Folding Chaperone Metal Ion Binding Disordered Domain Specific Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Vesicle-mediated Transport Positive Regulation Of Intracellular Protein Transport	Cell Fate Specification Negative Regulation Of Protein Phosphorylation Protein Folding Apoptotic Process Signal Transduction Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Regulation Of Gene Expression Dorsal/ventral Neural Tube Patterning Neural Tube Development BMP Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process Neuron Fate Specification Regulation Of Macromolecule Metabolic Process Protein Localization To Mitochondrion Regulation Of Mitophagy
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 24097068 25961943 20686565) Height ( 28552196) Hip circumference adjusted for BMI ( 28552196 34021172) LDL cholesterol levels ( 32203549) Refractive error ( 32231278) Schizophrenia ( 28991256) Total cholesterol levels ( 28334899 30275531) Triglycerides ( 25961943) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Plasma parathyroid hormone levels ( 30134803) Urinary potassium excretion ( 31409800)
Interacting Genes		233 interacting genes: ABHD16A ADGRE2 ADIPOQ AGPAT4 AGTRAP AIG1 ALG10 AOC2 APOC3 APOD APOL2 AQP10 AQP2 AQP3 ARLN ASGR1 ATP13A1 ATP1B4 ATP6V0C BCL2L1 BET1 BIK BNIP3 BTN2A2 BUD31 C14orf180 C2 C3orf52 CCDC167 CCR2 CCR4 CCR8 CD207 CD302 CD81 CDIPT CDS2 CEBPA CFHR5 CHRM4 CIAO2A CLCA4 CLDN19 CLDN8 CLDND2 CMTM5 CNIH1 CNIH3 COL4A5 COX20 CTSA CTXN3 CXorf66 CYB561 CYB561D2 CYB5B CYBC1 CYP4F2 DEFB103A DEFB103B EBP EMC6 EMP1 EMP3 ENTPD3 ERG28 ERGIC1 EXTL1 F2RL1 FA2H FAM3C FAXDC2 FETUB FIS1 FKBP8 FUNDC2 FXYD2 FXYD3 FXYD6 FXYD6-FXYD2 GAST GIMAP1 GIMAP5 GJB2 GOSR2 GPM6B GPR151 GPR152 GPR35 GPR37 GYPA HHATL HMOX1 HMOX2 IFITM3 IGFBP5 INSIG2 ITGAM JAGN1 KCNK1 LHFPL5 LPAR3 LPCAT2 MALL MARCHF2 MARCHF5 MFF MFSD6 MIP MS4A13 MYADM NDRG4 NDUFB6 NEU1 NINJ2 NKG7 NRG4 NRM NSG1 OGT ORMDL1 ORMDL2 ORMDL3 PAQR5 PAQR7 PEX11G PEX16 PGAP2 PLLP PLN PLP1 PLPP4 PMP22 PNLIPRP1 POMGNT1 RFT1 RHAG RTP2 RUSF1 SCARB2 SCD SEC22B SEC23A SELENOK SERP2 SFXN5 SLC13A3 SLC1A1 SLC29A2 SLC30A2 SLC35A1 SLC35A4 SLC35B2 SLC35B4 SLC38A7 SLC41A1 SLC41A2 SLC49A3 SMAGP SMCO4 SMIM1 SMIM3 SNCA SNORC SPN STATH STRIT1 STX12 STX1B STX3 STX8 SYNGR1 SYNJ2BP SYS1 TAP1 TECR TF THBD TM4SF4 TMEM100 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM140 TMEM141 TMEM147 TMEM14A TMEM14B TMEM179B TMEM203 TMEM218 TMEM222 TMEM229B TMEM243 TMEM254 TMEM42 TMEM60 TMEM65 TMEM86A TMEM86B TMEM97 TMUB2 TNFRSF10C TOMM6 TRAM1L1 TRARG1 TREX1 TRIM32 TSPAN33 TSPO2 UBIAD1 UNC50 UNC93B1 UPK1B VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VKORC1L1 VMP1 VSTM1 VTI1B YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC15 ZDHHC21 ZFPL1	52 interacting genes: AQP6 ARHGEF5 ARL13B ATP13A2 BCL2 BCL2L1 BIK BNIPL CD79A CIDEB CLCN1 CXCR2 CYB561 CYBRD1 EBP EGFR ELOVL4 ERBB2 ERGIC3 FAM174A FGF14 GPR37 JAGN1 MAPK14 MTOR OGT PEX12 PLN PPP3CA PSMC1 PSMD2 RETREG3 RHBDD2 RHEB SCN3B SHANK3 SLC10A1 SLC10A6 SLC35A5 SLC35B1 SLC71A2 SMO TERF1 TMEM14B TMEM254 TMEM31 TMEM43 TMEM45B TMEM80 TMX1 VHL ZFPL1
Entrez ID		51614	23770
HPRD ID		15306	05327
Ensembl ID		ENSG00000125991	ENSG00000105701
Uniprot IDs		A2TJK5 Q9Y282	B2R8G6 Q14318
PDB IDs			2AWG 2D9F 2F2D 2MF9 3EY6 5MGX
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Plasma Membrane Establishment Of Protein Localization To Membrane Endomembrane System Vesicle Fusion Golgi Membrane Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Localization Within Membrane Chemical Homeostasis Membrane Fusion Protein Localization To Membrane Membrane Organization SNARE Complex Assembly Protein Localization To Cell Periphery Establishment Of Protein Localization Establishment Of Protein Localization To Plasma Membrane Mitochondrial Outer Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Transmembrane Transport SNARE Binding Cellular Localization Membrane Docking Cholesterol Binding Bleb Assembly Structural Constituent Of Myelin Sheath Vesicle Organization Organelle Localization By Membrane Tethering Transport Vesicle Protein Localization To Plasma Membrane Intracellular Chemical Homeostasis Vesicle-mediated Transport To The Plasma Membrane Vesicle Docking Golgi Apparatus Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Homeostatic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Water Channel Activity Endosome To Plasma Membrane Protein Transport Golgi Vesicle Transport Mitochondrial Membrane Myelination Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of Cellular Localization Mitochondrial Membrane Negative Regulation Of Catabolic Process Regulation Of Protein Localization Bcl-2 Family Protein Complex Protein Binding Transmembrane Transport Negative Regulation Of Autophagy Dendritic Cell Apoptotic Process Ascorbate Homeostasis Intracellular Signal Transduction Regulation Of Membrane Potential Transmembrane Monodehydroascorbate Reductase Activity Striated Muscle Cell Development Skeletal Muscle Fiber Development Bile Acid:sodium Symporter Activity Positive Regulation Of Growth Regulation Of Protein Catabolic Process BH3 Domain Binding Myotube Cell Development Regulation Of Establishment Of Protein Localization Muscle Cell Development Negative Regulation Of Calcium Ion Transmembrane Transport Intracellular Signaling Cassette Regulation Of TORC1 Signaling Channel Activity ERBB2-EGFR Signaling Pathway Cell Morphogenesis Autophagy Negative Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Striated Muscle Cell Differentiation Oligodendrocyte Differentiation Monoatomic Ion Transport Regulation Of Myotube Differentiation Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Translational Initiation Pyrimidine Nucleotide-sugar Transmembrane Transport Regulation Of Growth Positive Regulation Of Translational Initiation Mononuclear Cell Proliferation Nucleotide-sugar Transmembrane Transport Negative Regulation Of Calcium Ion Transport Identical Protein Binding Proteasomal Protein Catabolic Process Proteasome Regulatory Particle, Base Subcomplex Proteasome Regulatory Particle Ciliary Membrane
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