GRK1 and CAV1

Number of citations of the paper that reports this interaction (PMID 10085129)
37

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		GRK1	CAV1
Gene Name		G protein-coupled receptor kinase 1	caveolin 1, caveolae protein, 22kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Disc Membrane	Golgi Membrane Acrosomal Membrane Intracellular Endosome Endoplasmic Reticulum Lipid Particle Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Cilium Cell Cortex Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity G-protein Coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity	Receptor Binding Patched Binding Structural Molecule Activity Protein Binding Cholesterol Binding Peptidase Activator Activity Enzyme Binding Protein Kinase Binding Protein Complex Scaffold Identical Protein Binding Ion Channel Binding Nitric-oxide Synthase Binding Inward Rectifier Potassium Channel Inhibitor Activity
	Biological Process	Visual Perception Phototransduction, Visible Light Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Photoreceptor Cell Morphogenesis Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Protein Autophosphorylation Post-embryonic Retina Morphogenesis In Camera-type Eye	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Inactivation Of MAPK Activity Angiogenesis Vasculogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Response To Ischemia Regulation Of The Force Of Heart Contraction By Chemical Signal Triglyceride Metabolic Process Calcium Ion Transport Cellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Skeletal Muscle Tissue Development Lactation Blood Coagulation Protein Localization Cellular Response To Starvation Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Peptidase Activity Viral Process Vesicle Organization Regulation Of Fatty Acid Metabolic Process Lipid Storage Regulation Of Blood Coagulation Cholesterol Transport Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Maintenance Of Protein Location In Cell Response To Progesterone Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Nitric Oxide Homeostasis Vasoconstriction Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Cholesterol Homeostasis Negative Regulation Of MAPK Cascade Response To Estrogen Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Vasoconstriction Nitric Oxide Metabolic Process Negative Regulation Of JAK-STAT Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Metalloenzyme Activity Leukocyte Migration Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Cytosolic Calcium Ion Homeostasis Response To Calcium Ion Membrane Depolarization Regulation Of Peptidase Activity Calcium Ion Homeostasis Mammary Gland Involution Negative Regulation Of Protein Tyrosine Kinase Activity Caveola Assembly Cellular Response To Hyperoxia Caveolin-mediated Endocytosis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Membrane Repolarization During Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Inward Rectifier Potassium Channel Activity Protein Localization To Basolateral Plasma Membrane Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Anoikis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction	Metabolism of lipids and lipoproteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Lipid digestion, mobilization, and transport Signaling by Wnt Basigin interactions VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall eNOS activation disassembly of the destruction complex and recruitment of AXIN to the membrane Metabolism of nitric oxide Signaling by VEGF TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis NOSTRIN mediated eNOS trafficking VEGFR2 mediated vascular permeability XAV939 inhibits tankyrase, stabilizing AXIN eNOS activation and regulation Signaling by WNT in cancer
Drugs
Diseases
GWAS			Atrial fibrillation ( 22544366) Electrocardiographic traits ( 20062063) Glaucoma (primary open-angle) ( 20835238) PR interval ( 20062060 23139255)
Protein-Protein Interactions		8 interactors: CALM1 CAV1 PDE6D RCVRN RHO SNCA SNCB SNCG	81 interactors: ABCB1 ABL1 ADRBK1 AKAP1 APP AR BMX BSG BST1 BTK CAV2 CD40 CSK CSNK2A1 CSNK2A2 DAG1 DNM1 EDNRB EGFR ERBB2 ESR1 FLNA FLOT2 FYN GJA1 GJA3 GJB2 GNAI2 GRB7 GRK1 GRK5 HRAS HTR1F IGF1R IGFBP3 ILK INSR IRS1 KDR LATS1 LRP1 MALL MAPK1 MAPK3 MMP14 NEU3 NGFR NOS2 NOS3 NTRK1 PDGFRA PDGFRB PLD1 PLD2 PPP1CA PPP2CA PRNP PTEN PTGS2 PTPN1 PTPN11 PTPN6 PTPRF RAC1 RCVRN RHOA RHOC S1PR1 SCP2 SNCA SOS1 SRC STOML3 STRN STRN4 TGFBR1 TNFRSF1B TRAF2 TRAF6 TRPC1 VCP
Entrez ID		6011	857
HPRD ID		01585	03028
Ensembl ID			ENSG00000105974
Uniprot IDs		Q15835	A9XTE5 Q03135 Q2TNI1 Q59E85 Q7Z4F3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Calcium Ion Transport Regulation Of Ion Transport Regulation Of Oxidoreductase Activity Phototransduction, Visible Light Regulation Of Calcium Ion Transport Into Cytosol Detection Of Visible Light Positive Regulation Of Calcium Ion Transport Cellular Response To Light Stimulus Phototransduction Negative Regulation Of Ion Transport Detection Of Light Stimulus Negative Regulation Of Monooxygenase Activity Response To Abiotic Stimulus Response To Inorganic Substance Cellular Response To Radiation Regulation Of Ion Homeostasis Regulation Of Dopamine Secretion Synapse Organization Visual Perception Detection Of Abiotic Stimulus Sensory Perception Of Light Stimulus Synaptic Transmission Regulation Of Catalytic Activity Negative Regulation Of Oxidoreductase Activity Positive Regulation Of Ion Transport Dopamine Metabolic Process Nitric Oxide Metabolic Process Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Transporter Activity Catecholamine Metabolic Process Receptor Internalization Positive Regulation Of Lyase Activity Regulation Of Signaling Negative Regulation Of Ion Transmembrane Transport Response To Cocaine Response To Organic Cyclic Compound Response To External Stimulus Negative Regulation Of Protein Phosphorylation Cell-cell Signaling Response To Metal Ion Negative Regulation Of Transmembrane Transport Response To Light Stimulus	Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Signal Transduction Locomotion Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Response To External Stimulus Response To Stimulus Response To Organic Substance Cellular Response To Stimulus Regulation Of Cell Proliferation Regulation Of Phosphorylation Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Wound Healing Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To Wounding Positive Regulation Of Phosphorylation Cell Development Regulation Of Catalytic Activity Developmental Process Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Kinase Activity Regulation Of Body Fluid Levels Chemotaxis Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Catalytic Activity Blood Coagulation Anatomical Structure Development Hemostasis Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Tissue Development Intracellular Signal Transduction Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway System Development Neurotrophin Signaling Pathway Neuron Projection Morphogenesis Response To Stress Cell Morphogenesis Involved In Neuron Differentiation
Tagcloud ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk2 grk4 grk5 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	17beta caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmr1 fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna
Tagcloud (Difference) ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk2 grk4 grk5 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	17beta caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmr1 fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna
Tagcloud (Intersection) ?