GRK1

Description		G protein-coupled receptor kinase 1
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Membrane Cell Projection Photoreceptor Disc Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity ATP Binding Kinase Activity Transferase Activity Rhodopsin Kinase Activity
	Biological Process	Signal Transduction Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Light Stimulus Regulation Of Signal Transduction G Protein-coupled Opsin Signaling Pathway Regulation Of Opsin-mediated Signaling Pathway Protein Autophosphorylation
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade
Drugs
Diseases		Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO)
GWAS
Interacting Genes		9 interacting genes: ADRB2 CALM1 CAV1 PDE6D RCVRN RHO SNCA SNCB SNCG
Entrez ID		6011
HPRD ID		01585
Ensembl ID		ENSG00000185974
Uniprot IDs		Q15835
PDB IDs		5AFP
Enriched GO Terms of Interacting Partners?		Presynaptic Endocytosis Cuprous Ion Binding Endocytosis Vesicle-mediated Transport In Synapse Import Into Cell Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Synaptic Vesicle Endocytosis Axon Terminus Regulation Of Calcium Ion Transport Vesicle-mediated Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Cell Communication By Electrical Coupling Establishment Of Localization In Cell Regulation Of Transport Inclusion Body Regulation Of Membrane Potential Regulation Of Calcium Ion Transmembrane Transport Regulation Of Dopamine Secretion Regulation Of Muscle Contraction Receptor-mediated Endocytosis Modulation Of Chemical Synaptic Transmission Regulation Of Cardiac Muscle Cell Action Potential Visual Perception Dopamine Metabolic Process Sensory Perception Of Light Stimulus Cilium Calcium Ion Binding Regulation Of Catecholamine Secretion Phototransduction Cell Projection Regulation Of Muscle System Process Protein Sequestering Activity Catecholamine Metabolic Process Detection Of Stimulus Synapse Organization Sperm Midpiece Regulation Of Monoatomic Cation Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Smooth Muscle Contraction Positive Regulation Of Mini Excitatory Postsynaptic Potential System Process Long-term Synaptic Potentiation Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Action Potential Inward Rectifier Potassium Channel Inhibitor Activity Positive Regulation Of Calcium Ion Transmembrane Transport Photoreceptor Inner Segment
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