AMOTL2 and LMNB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AMOTL2	LMNB2
Description		angiomotin like 2	lamin B2
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Endosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Junction Cytoplasmic Vesicle Cell Projection Recycling Endosome Anchoring Junction	Nucleus Nuclear Envelope Nuclear Lamina Intermediate Filament Nuclear Membrane
	Molecular Function	Protein Binding Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Endothelial Cell Morphogenesis Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Wnt Signaling Pathway Actin Cytoskeleton Organization Regulation Of Cell Migration Hippo Signaling Positive Regulation Of Protein Localization	Nuclear Envelope Organization Cytoskeleton Organization Nuclear Migration Heterochromatin Formation Nuclear Pore Localization Protein Localization To Nuclear Envelope
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS		Cadmium levels ( 26025379) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Interacting Genes		92 interacting genes: AMOT BFSP2 BLZF1 BRMS1L BYSL CARD9 CCDC185 CCDC196 CCDC57 CCHCR1 CDC37 CDR2 CHCHD3 CINP CYTH4 DAXX DDIT3 DSCAM DTNB DYNLL1 DZIP1L EIF4E2 FAM184A FAM90A1 FBXO7 FCRL5 FXR2 GCC1 GNG11 GNG5 GOLGA2 GSTM5 KIF9 KRT1 KRT13 KRT15 KRT19 KRT20 KRT31 KRT38 KRTAP10-5 KRTAP4-2 L3MBTL2 LMNB2 LMO3 LMO4 MAD1L1 MAGEA4 MAGOHB MFAP1 MORF4L2 MPP1 MTCL2 MTMR6 MTNR1A MYO5B NDC80 NF2 NFIL3 NME7 NTAQ1 PIBF1 PPP2CA PPP2R1A PRKAA2 PRPF18 PSMC3 RAD51D RALBP1 RASAL3 RASSF5 RNF20 RNF40 RNF8 SAAL1 SH3RF2 SMARCE1 SP100 SPAG5 SPOP SPP1 TCEA2 THRA TMCC2 TNKS2 TRAF2 TRIM27 TSGA10IP YES1 ZBED1 ZBTB16 ZGPAT	28 interacting genes: AMOT AMOTL2 CA8 CCDC120 CCDC88B CDC37 EFHC2 FH GOLGA2 LZTS1 MFAP1 MID2 OVOL1 PIBF1 POU6F2 PPP1R13B PRKCD SVIL TFIP11 THAP1 TMPO TP53BP2 TRIM27 TSGA10IP USP2 WASHC3 ZC2HC1C ZFHX3
Entrez ID		51421	84823
HPRD ID		16485	01037
Ensembl ID		ENSG00000114019	ENSG00000176619
Uniprot IDs		Q9Y2J4	Q03252
PDB IDs			2LLL
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Intermediate Filament Organization Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Protein Binding Identical Protein Binding Structural Constituent Of Cytoskeleton Cytoskeleton Organization Ubiquitin Protein Ligase Binding Structural Molecule Activity Nucleus Cytosol Centriolar Satellite Organelle Organization Protein Polyubiquitination Centrosome Chromosome, Centromeric Region HULC Complex PML Body Supramolecular Fiber Organization Ubiquitin Ligase Complex Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Primary Metabolic Process Protein Ubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Cell Cycle	Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Regulation Of Actin Filament Organization Cytoplasm Regulation Of Autophagy Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription
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