AMOTL2 and NFIL3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		AMOTL2	NFIL3
Name		angiomotin like 2	nuclear factor, interleukin 3 regulated
Structure		No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Endosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Junction Cytoplasmic Vesicle Cell Projection Recycling Endosome Anchoring Junction	Chromatin Nucleus RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding Actin Filament Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Endothelial Cell Morphogenesis Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Wnt Signaling Pathway Actin Cytoskeleton Organization Regulation Of Cell Migration Hippo Signaling Positive Regulation Of Protein Localization	Negative Regulation Of Transcription By RNA Polymerase II Natural Killer Cell Differentiation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Immune Response Circadian Rhythm Positive Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Interleukin-4
Pathways		Signaling by Hippo	None
GWAS		Cadmium levels ( 26025379 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 )	Bipolar disorder (inflammation and infection response interaction) ( 25781172 ) Birth weight ( 31043758 ) Inflammatory bowel disease ( 23128233 ) Offspring birth weight ( 31043758 )
Interacting Genes		92 interacting genes: AMOT BFSP2 BLZF1 BRMS1L BYSL CARD9 CCDC185 CCDC196 CCDC57 CCHCR1 CDC37 CDR2 CHCHD3 CINP CYTH4 DAXX DDIT3 DSCAM DTNB DYNLL1 DZIP1L EIF4E2 FAM184A FAM90A1 FBXO7 FCRL5 FXR2 GCC1 GNG11 GNG5 GOLGA2 GSTM5 KIF9 KRT1 KRT13 KRT15 KRT19 KRT20 KRT31 KRT38 KRTAP10-5 KRTAP4-2 L3MBTL2 LMNB2 LMO3 LMO4 MAD1L1 MAGEA4 MAGOHB MFAP1 MORF4L2 MPP1 MTCL2 MTMR6 MTNR1A MYO5B NDC80 NF2 NFIL3 NME7 NTAQ1 PIBF1 PPP2CA PPP2R1A PRKAA2 PRPF18 PSMC3 RAD51D RALBP1 RASAL3 RASSF5 RNF20 RNF40 RNF8 SAAL1 SH3RF2 SMARCE1 SP100 SPAG5 SPOP SPP1 TCEA2 THRA TMCC2 TNKS2 TRAF2 TRIM27 TSGA10IP YES1 ZBED1 ZBTB16 ZGPAT	18 interacting genes: AMOTL2 BATF CFTR CREB3 DDIT3 DELEC1 DNMT3L DR1 FHL1 GMCL1 HSF2BP MAFF MAFG PDE9A PIH1D2 RINT1 TRAF2 UBR5
Entrez ID		51421	4783
HPRD ID		16485	05619
Ensembl ID		ENSG00000114019	ENSG00000165030
Uniprot IDs		Q9Y2J4	Q16649
PDB IDs		Not available	8K86 8K89 8K8A
GO Terms Enriched among Interactors		Keratin Filament Intermediate Filament Intermediate Filament Organization Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Protein Binding Identical Protein Binding Structural Constituent Of Cytoskeleton Cytoskeleton Organization Ubiquitin Protein Ligase Binding Structural Molecule Activity Nucleus Cytosol Centriolar Satellite Organelle Organization Protein Polyubiquitination Centrosome Chromosome, Centromeric Region HULC Complex PML Body Supramolecular Fiber Organization Ubiquitin Ligase Complex Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Primary Metabolic Process Protein Ubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Cell Cycle	RNA Polymerase II Transcription Regulator Complex Integrated Stress Response Signaling CAMP Response Element Binding Protein Binding Response To Endoplasmic Reticulum Stress Cellular Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Male Meiosis I Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Ion Transport Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress DNA Damage Response DNA-binding Transcription Factor Activity TORC2 Complex Disassembly Positive Regulation Of Deacetylase Activity Meiosis I Positive Regulation Of Gene Expression Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Regulation Of DNA-templated Transcription Negative Regulation Of Determination Of Dorsal Identity Negative Regulation Of DNA-templated Transcription Endoplasmic Reticulum Unfolded Protein Response CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II CHOP-ATF4 Complex Intracellular Signal Transduction CHOP-ATF3 Complex Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Diaphragm Contraction Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Vascular Associated Smooth Muscle Cell Migration Negative Cofactor 2 Complex General Transcription Initiation Factor Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Epidermis Development Sequence-specific Double-stranded DNA Binding Regulation Of Epidermal Cell Differentiation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Meiosis I Cell Cycle Process