AMOTL2 and GSTM5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AMOTL2	GSTM5
Description		angiomotin like 2	glutathione S-transferase mu 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Endosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Junction Cytoplasmic Vesicle Cell Projection Recycling Endosome Anchoring Junction	Cytoplasm Cytosol
	Molecular Function	Protein Binding Actin Filament Binding	Glutathione Transferase Activity Protein Binding Transferase Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Endothelial Cell Morphogenesis Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Wnt Signaling Pathway Actin Cytoskeleton Organization Regulation Of Cell Migration Hippo Signaling Positive Regulation Of Protein Localization	Glutathione Metabolic Process
Pathways		Signaling by Hippo	Glutathione conjugation
Drugs			Glutathione Glutathione disulfide Deoxycholic acid
Diseases
GWAS		Cadmium levels ( 26025379) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		92 interacting genes: AMOT BFSP2 BLZF1 BRMS1L BYSL CARD9 CCDC185 CCDC196 CCDC57 CCHCR1 CDC37 CDR2 CHCHD3 CINP CYTH4 DAXX DDIT3 DSCAM DTNB DYNLL1 DZIP1L EIF4E2 FAM184A FAM90A1 FBXO7 FCRL5 FXR2 GCC1 GNG11 GNG5 GOLGA2 GSTM5 KIF9 KRT1 KRT13 KRT15 KRT19 KRT20 KRT31 KRT38 KRTAP10-5 KRTAP4-2 L3MBTL2 LMNB2 LMO3 LMO4 MAD1L1 MAGEA4 MAGOHB MFAP1 MORF4L2 MPP1 MTCL2 MTMR6 MTNR1A MYO5B NDC80 NF2 NFIL3 NME7 NTAQ1 PIBF1 PPP2CA PPP2R1A PRKAA2 PRPF18 PSMC3 RAD51D RALBP1 RASAL3 RASSF5 RNF20 RNF40 RNF8 SAAL1 SH3RF2 SMARCE1 SP100 SPAG5 SPOP SPP1 TCEA2 THRA TMCC2 TNKS2 TRAF2 TRIM27 TSGA10IP YES1 ZBED1 ZBTB16 ZGPAT	3 interacting genes: AMOTL2 CDC42 GPKOW
Entrez ID		51421	2949
HPRD ID		16485	00711
Ensembl ID		ENSG00000114019	ENSG00000134201
Uniprot IDs		Q9Y2J4	P46439 Q5T8R1 Q5T8R2
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Intermediate Filament Organization Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Protein Binding Identical Protein Binding Structural Constituent Of Cytoskeleton Cytoskeleton Organization Ubiquitin Protein Ligase Binding Structural Molecule Activity Nucleus Cytosol Centriolar Satellite Organelle Organization Protein Polyubiquitination Centrosome Chromosome, Centromeric Region HULC Complex PML Body Supramolecular Fiber Organization Ubiquitin Ligase Complex Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Primary Metabolic Process Protein Ubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Cell Cycle	Wnt Signaling Pathway Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Establishment Of Cell Polarity Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Establishment Or Maintenance Of Cell Polarity Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Leading Edge Membrane Thioesterase Binding Actin Filament-based Process Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Actin Cytoskeleton Organization Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Golgi Localization Endothelial Cell Morphogenesis Cardiac Conduction System Development Establishment Of Epithelial Cell Apical/basal Polarity Cell Migration Involved In Heart Development Dendritic Spine Morphogenesis Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Dendritic Cell Migration Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Embryonic Heart Tube Development Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Positive Regulation Of Lamellipodium Assembly Spindle Midzone Nuclear Migration Hippo Signaling Establishment Of Epithelial Cell Polarity Positive Regulation Of Filopodium Assembly Phagocytosis, Engulfment Nucleus Localization Heart Process Dendritic Spine Organization Positive Regulation Of Lamellipodium Organization
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