LMNB2 and FH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LMNB2	FH
Description		lamin B2	fumarate hydratase
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Lamina Intermediate Filament Nuclear Membrane	Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Site Of Double-strand Break Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Identical Protein Binding	Catalytic Activity Fumarate Hydratase Activity Protein Binding Lyase Activity Histone Binding
	Biological Process	Nuclear Envelope Organization Cytoskeleton Organization Nuclear Migration Heterochromatin Formation Nuclear Pore Localization Protein Localization To Nuclear Envelope	Urea Cycle Regulation Of Arginine Metabolic Process Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Arginine Metabolic Process DNA Damage Response Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			Citric acid cycle (TCA cycle) Mitochondrial protein degradation
Drugs
Diseases			Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency Multiple cutaneous and uterine leiomyomata Renal cell carcinoma
GWAS			Daytime sleep phenotypes ( 27126917) Major depressive disorder ( 27479909) Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: AMOT AMOTL2 CA8 CCDC120 CCDC88B CDC37 EFHC2 FH GOLGA2 LZTS1 MFAP1 MID2 OVOL1 PIBF1 POU6F2 PPP1R13B PRKCD SVIL TFIP11 THAP1 TMPO TP53BP2 TRIM27 TSGA10IP USP2 WASHC3 ZC2HC1C ZFHX3	18 interacting genes: CCDC102B CCDC57 CCNDBP1 CSTPP1 DGCR6 EXOSC5 GRB2 H2AZ1 KLHL6 LMNB2 MDH2 OGT PIM1 POLR1C PRKDC SAT1 TNPO2 TTC19
Entrez ID		84823	2271
HPRD ID		01037	00652
Ensembl ID		ENSG00000176619	ENSG00000091483
Uniprot IDs		Q03252	A0A0S2Z4C3 P07954
PDB IDs		2LLL	3E04 5D6B 5UPP 6EBT 6V8F 6VBE 7LUB
Enriched GO Terms of Interacting Partners?		Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Regulation Of Actin Filament Organization Cytoplasm Regulation Of Autophagy Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription	Non-canonical Inflammasome Complex Assembly
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