LMNB2 and OVOL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LMNB2	OVOL1
Description		lamin B2	ovo like transcriptional repressor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Lamina Intermediate Filament Nuclear Membrane	Nucleus
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nuclear Envelope Organization Cytoskeleton Organization Nuclear Migration Heterochromatin Formation Nuclear Pore Localization Protein Localization To Nuclear Envelope	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Regulation Of Transcription By RNA Polymerase II Spermatogenesis Mesoderm Development Epidermis Development Epidermal Cell Differentiation Negative Regulation Of Keratinocyte Proliferation Skin Development Keratinocyte Proliferation Meiotic Cell Cycle Phase Transition Germline Cell Cycle Switching, Mitotic To Meiotic Cell Cycle Stem Cell Proliferation Negative Regulation Of Meiotic Cell Cycle Phase Transition Negative Regulation Of Stem Cell Proliferation
Pathways
Drugs
Diseases
GWAS			A body shape index ( 34021172) Acne (severe) ( 30542056 24927181) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 30013184) Apolipoprotein A1 levels ( 32203549) Asthma ( 31361310 30929738 31619474 32296059 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Atopic dermatitis ( 22197932 23042114 26482879) Atopic march ( 26542096) Basal cell carcinoma ( 33549134) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 23535729) Chronic kidney disease ( 20383146) DNA methylation (variation) ( 23725790) Eczema ( 31361310) Estimated glomerular filtration rate ( 31451708) High density lipoprotein cholesterol levels ( 31928498) Hip circumference adjusted for BMI ( 34021172) IgG N-glycosylation phenotypes (multivariate analysis) ( 33710309) Medication use (diuretics) ( 31015401) Rosacea symptom severity ( 29771307) Serum uric acid levels ( 30993211) Systemic lupus erythematosus ( 33272962 26502338 28714469) Systolic blood pressure ( 31928498) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Urate levels ( 23263486) Waist circumference ( 31928498) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		28 interacting genes: AMOT AMOTL2 CA8 CCDC120 CCDC88B CDC37 EFHC2 FH GOLGA2 LZTS1 MFAP1 MID2 OVOL1 PIBF1 POU6F2 PPP1R13B PRKCD SVIL TFIP11 THAP1 TMPO TP53BP2 TRIM27 TSGA10IP USP2 WASHC3 ZC2HC1C ZFHX3	3 interacting genes: FAM90A1 LMNB2 MAFF
Entrez ID		84823	5017
HPRD ID		01037	09080
Ensembl ID		ENSG00000176619	ENSG00000172818
Uniprot IDs		Q03252	G3V1B0 O14753
PDB IDs		2LLL
Enriched GO Terms of Interacting Partners?		Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Regulation Of Actin Filament Organization Cytoplasm Regulation Of Autophagy Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription
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