AMOTL2 and GNG5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		AMOTL2	GNG5
Gene Name		angiomotin like 2	guanine nucleotide binding protein (G protein), gamma 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Tight Junction Apical Plasma Membrane Cytoplasmic Vesicle Recycling Endosome	Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	GTPase Activity Signal Transducer Activity PDZ Domain Binding
	Biological Process	Wnt Signaling Pathway Hippo Signaling	Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus
Pathways		Signaling by Hippo	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		52 interactors: BLZF1 BRMS1L CARD9 CCHCR1 CDR2 CYTH4 DDIT3 DYNLL1 EIF4E2 FAM184A FXR2 GCC1 GNG11 GNG5 GOLGA2 GSTM5 KRT13 KRT15 KRT19 KRT20 KRT31 KRT38 KRTAP10-5 KRTAP4-2 LMO4 MAD1L1 MAGEA4 MAGOHB MFAP1 MPP1 MTMR6 MYO5B NDC80 NFIL3 PSMC3 RAD51D RALBP1 RASSF5 RNF20 RNF40 SH3RF2 SMARCE1 SP100 SPAG5 SPP1 THRA TMCC2 TRAF2 TRIM27 WDYHV1 ZBED1 ZGPAT	12 interactors: AMOTL2 EPS15L1 GNB1 GNB2 GNB3 GNB4 GNB5 GOLGA2 KRT31 KRT40 MDFI TRAF1
Entrez ID		51421	2787
HPRD ID		16485	11865
Ensembl ID		ENSG00000114019	ENSG00000174021
Uniprot IDs		Q9Y2J4	P63218
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Localization Histone H2B Ubiquitination Regulation Of Cellular Localization Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Mitotic Cell Cycle Organelle Organization Chromosome Organization Protein Ubiquitination Histone Monoubiquitination Negative Regulation Of Viral Transcription Cell Cycle Negative Regulation Of Transcription, DNA-templated Protein Modification By Small Protein Conjugation Regulation Of Establishment Of Protein Localization Protein K63-linked Ubiquitination Histone Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter Protein Trimerization Negative Regulation Of Determination Of Dorsal Identity Regulation Of Metaphase Plate Congression Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Response To Glucagon Stimulus	Cellular Response To Glucagon Stimulus Response To Glucagon Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Signal Transduction Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Rhodopsin Mediated Signaling Pathway Signaling Rhodopsin Mediated Signaling Pathway Cell Communication Cellular Response To Hormone Stimulus Cellular Response To Stimulus Response To Organonitrogen Compound Phototransduction, Visible Light Response To Hormone Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Negative Regulation Of Binding Detection Of Light Stimulus Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Response To Stimulus Cellular Response To Radiation Synaptic Transmission Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Oxidation-reduction Process Regulation Of Signal Transduction Regulation Of Binding Cellular Response To Prostaglandin E Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell-cell Signaling Cellular Response To Organic Substance Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Trophoblast Giant Cell Differentiation Regulation Of Signaling Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity
Tagcloud ?		actin alanine amots angiomotin collectively consensus contain core dissociation endogenously exogenous filaments hippo hxrxxs lats1 lats2 mapping mediate members mimic negatively phospho promoted s175a s175d serine taz yap	adcy8 adcy9 br1 br2 consisted disturbance endometrial endometrium eventually fos g2 g3 gnb1 gng11 gng12 kinin kinins kras map2k2 mapk1 microarrays mitogenic oligonucleotide plcb4 prkacb prkar1a prkca reaching u133a
Tagcloud (Difference) ?		actin alanine amots angiomotin collectively consensus contain core dissociation endogenously exogenous filaments hippo hxrxxs lats1 lats2 mapping mediate members mimic negatively phospho promoted s175a s175d serine taz yap	adcy8 adcy9 br1 br2 consisted disturbance endometrial endometrium eventually fos g2 g3 gnb1 gng11 gng12 kinin kinins kras map2k2 mapk1 microarrays mitogenic oligonucleotide plcb4 prkacb prkar1a prkca reaching u133a
Tagcloud (Intersection) ?