AMOTL2 and TNKS2

Number of citations: 0 (PubMedID 27521426)
Data Source: BioGRID (enzymatic study)

		AMOTL2	TNKS2
Name		angiomotin like 2	tankyrase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Endosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Junction Cytoplasmic Vesicle Cell Projection Recycling Endosome Anchoring Junction	Golgi Membrane Pericentriolar Material Chromosome, Telomeric Region Nucleus Nuclear Envelope Chromosome Cytoplasm Golgi Apparatus Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Actin Filament Binding	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding Metal Ion Binding NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Endothelial Cell Morphogenesis Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Wnt Signaling Pathway Actin Cytoskeleton Organization Regulation Of Cell Migration Hippo Signaling Positive Regulation Of Protein Localization	Protein Polyubiquitination Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways		Signaling by Hippo	TCF dependent signaling in response to WNT Degradation of AXIN XAV939 stabilizes AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
GWAS		Cadmium levels ( 26025379 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 )	Appendicular lean mass ( 33097823 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver volume ( 34128465 ) Serum alkaline phosphatase levels ( 33547301 )
Interacting Genes		92 interacting genes: AMOT BFSP2 BLZF1 BRMS1L BYSL CARD9 CCDC185 CCDC196 CCDC57 CCHCR1 CDC37 CDR2 CHCHD3 CINP CYTH4 DAXX DDIT3 DSCAM DTNB DYNLL1 DZIP1L EIF4E2 FAM184A FAM90A1 FBXO7 FCRL5 FXR2 GCC1 GNG11 GNG5 GOLGA2 GSTM5 KIF9 KRT1 KRT13 KRT15 KRT19 KRT20 KRT31 KRT38 KRTAP10-5 KRTAP4-2 L3MBTL2 LMNB2 LMO3 LMO4 MAD1L1 MAGEA4 MAGOHB MFAP1 MORF4L2 MPP1 MTCL2 MTMR6 MTNR1A MYO5B NDC80 NF2 NFIL3 NME7 NTAQ1 PIBF1 PPP2CA PPP2R1A PRKAA2 PRPF18 PSMC3 RAD51D RALBP1 RASAL3 RASSF5 RNF20 RNF40 RNF8 SAAL1 SH3RF2 SMARCE1 SP100 SPAG5 SPOP SPP1 TCEA2 THRA TMCC2 TNKS2 TRAF2 TRIM27 TSGA10IP YES1 ZBED1 ZBTB16 ZGPAT	17 interacting genes: AMOTL2 ANKRD28 ARAP3 DSCR9 GRB14 LNPEP MAPK1 MAVS MDC1 PTEN SASH1 SH3BP2 TERF1 TNKS TNKS1BP1 USP25 ZNF512B
Entrez ID		51421	80351
HPRD ID		16485	06182
Ensembl ID		ENSG00000114019	ENSG00000107854
Uniprot IDs		Q9Y2J4	Q9H2K2
PDB IDs		Not available	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT 5OWS 5OWT 6TG4 6TKM 6TKN 6TKP 6TKQ 6TKR 6TKS 7A1S 7O6X 7POX 7R3Z 8ALY
GO Terms Enriched among Interactors		Keratin Filament Intermediate Filament Intermediate Filament Organization Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Protein Binding Identical Protein Binding Structural Constituent Of Cytoskeleton Cytoskeleton Organization Ubiquitin Protein Ligase Binding Structural Molecule Activity Nucleus Cytosol Centriolar Satellite Organelle Organization Protein Polyubiquitination Centrosome Chromosome, Centromeric Region HULC Complex PML Body Supramolecular Fiber Organization Ubiquitin Ligase Complex Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Primary Metabolic Process Protein Ubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Cell Cycle	Protein Polyubiquitination Ankyrin Repeat Binding Positive Regulation Of Telomere Maintenance Peptidyl-threonine Phosphorylation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Process Telomere Maintenance Via Telomerase Protein Ubiquitination RNA-templated DNA Biosynthetic Process Negative Regulation Of Cell Cycle Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Modification By Small Protein Conjugation Molecular Adaptor Activity Protein Modification Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Response To DsRNA Phosphotyrosine Residue Binding Response To Exogenous DsRNA Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of IP-10 Production Post-translational Protein Modification Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Cytosine Metabolic Process Regulation Of Focal Adhesion Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Regulation Of Epithelial Cell Migration Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Regulation Of Peroxisome Organization Signal Transduction Insulin Receptor Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Interleukin-34-mediated Signaling Pathway Regulation Of Cell-substrate Junction Organization