ACSL4 and HTATIP2

Number of citations of the paper that reports this interaction (PubMedID 21252234)
49

Data Source:
BioGRID (pull down)

		ACSL4	HTATIP2
Description		acyl-CoA synthetase long chain family member 4	HIV-1 Tat interactive protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Plasma Membrane Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Extracellular Exosome	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Ligase Activity Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Palmitoyl-CoA Ligase Activity	Catalytic Activity Protein Serine/threonine Kinase Activity Protein Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Lipid Biosynthetic Process Neuron Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Insulin Secretion Negative Regulation Of Prostaglandin Secretion Long-chain Fatty-acyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Embryonic Process Involved In Female Pregnancy Fatty Acid Derivative Biosynthetic Process	Regulation Of Translation Positive Regulation Of Programmed Cell Death Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation
Pathways		Intracellular metabolism of fatty acids regulates insulin secretion Synthesis of very long-chain fatty acyl-CoAs
Drugs		Icosapent Troglitazone Rosiglitazone	Polyethylene glycol 400
Diseases		Non-syndromic X-linked mental retardation
GWAS		Mean platelet volume ( 32888494)	Bell's palsy ( 33602968) Fractional shortening ( 29403010) Obesity-related traits ( 23251661) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762)
Interacting Genes		7 interacting genes: APP CDK1 DSE HTATIP2 PRKCB UBR5 YWHAQ	29 interacting genes: ABHD4 ACSL4 AQP6 ASF1A CD79A CFTR EHHADH ETS1 FAM209A FITM2 FKBP7 GET1 HDAC6 HSD17B11 JAGN1 JPH1 MIEF1 MTIF3 NCOA5 PITPNC1 PLIN2 RAB5A REEP4 RETREG3 SH3GLB1 SLC10A6 SLC18A1 TMEM115 TMX2
Entrez ID		2182	10553
HPRD ID		02152	09288
Ensembl ID		ENSG00000068366	ENSG00000109854
Uniprot IDs		O60488 Q8TAF6	Q9BUP3
PDB IDs			2BKA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Protein Transport Positive Regulation Of Protein Localization Mitotic Nuclear Membrane Disassembly Membrane Disassembly Nuclear Membrane Disassembly Regulation Of Protein Localization To Nucleus Regulation Of Establishment Of Protein Localization Chromatin Remodeling Response To Copper Ion Positive Regulation Of Protein Import Into Nucleus Regulation Of Transport Chromatin Organization Protein Metabolic Process Positive Regulation Of Transport Nuclear Membrane Organization Intracellular Signal Transduction Regulation Of Protein Localization Protein Phosphorylation Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Pronuclear Fusion Phosphorylation Protein Serine/threonine Kinase Activity Positive Regulation Of Intracellular Protein Transport Acetylcholine Receptor Activator Activity Lipoprotein Particle Chromatin Binding Positive Regulation Of Protein Import Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Positive Regulation Of Protein Localization To Nucleus Histone H3T6 Kinase Activity Chondroitin-glucuronate 5-epimerase Activity Heterochromatin Boundary Formation PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Lipid Biosynthetic Process Lysophosphatidic Acid Acyltransferase Activity Endoplasmic Reticulum Organization Regulation Of Establishment Of Protein Localization Organelle Disassembly Fatty Acid Derivative Metabolic Process Alpha-linolenic Acid Metabolic Process
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