ACSL4 and DSE

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ACSL4	DSE
Gene Name		acyl-CoA synthetase long-chain family member 4	dermatan sulfate epimerase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Membrane Lipid Particle Membrane Integral Component Of Membrane Neuronal Cell Body ER-mitochondrion Membrane Contact Site Extracellular Vesicular Exosome	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity	Chondroitin-glucuronate 5-epimerase Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Response To Nutrient Lipid Biosynthetic Process Fatty Acid Transport Triglyceride Biosynthetic Process Positive Regulation Of Cell Growth Negative Regulation Of Prostaglandin Secretion Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Embryonic Process Involved In Female Pregnancy Dendritic Spine Development Response To Interleukin-15	Carbohydrate Metabolic Process Pathogenesis Heparan Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process
Pathways		Fatty Acyl-CoA Biosynthesis Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Triglyceride Biosynthesis Synthesis of very long-chain fatty acyl-CoAs	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Glycosaminoglycan metabolism Defective SLC26A2 causes chondrodysplasias Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs		Icosapent Troglitazone Rosiglitazone
Diseases
GWAS
Protein-Protein Interactions		3 interactors: APP DSE YWHAQ	2 interactors: ACSL4 CPSF3L
Entrez ID		2182	29940
HPRD ID		02152	05807
Ensembl ID		ENSG00000068366	ENSG00000111817
Uniprot IDs		O60488 Q5JWV8	B7Z765 Q9UL01
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Dermatan Sulfate Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Cellular Copper Ion Homeostasis Chondroitin Sulfate Biosynthetic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Brain Development Chondroitin Sulfate Proteoglycan Biosynthetic Process Head Development Heparan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Heparan Sulfate Proteoglycan Metabolic Process RNA Polyadenylation Neuron Recognition Substantia Nigra Development Apoptotic Process Central Nervous System Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Cell Death Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Death Death Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Neural Nucleus Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Proteoglycan Biosynthetic Process Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitochondrion Organization Chondroitin Sulfate Metabolic Process	Negative Regulation Of Prostaglandin Secretion Negative Regulation Of Icosanoid Secretion Response To Interleukin-15 Embryonic Process Involved In Female Pregnancy Dendritic Spine Development Long-chain Fatty-acyl-CoA Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Long-chain Fatty-acyl-CoA Metabolic Process Negative Regulation Of Lipid Transport SnRNA Processing Regulation Of Fatty Acid Transport SnRNA Metabolic Process Triglyceride Biosynthetic Process Fatty Acid Transport Acyl-CoA Metabolic Process Triglyceride Metabolic Process Regulation Of Lipid Transport Negative Regulation Of Ion Transport Neutral Lipid Metabolic Process Long-chain Fatty Acid Metabolic Process Positive Regulation Of Cell Growth Monocarboxylic Acid Transport Dendrite Development Regulation Of Anion Transport Coenzyme Biosynthetic Process Negative Regulation Of Secretion
Tagcloud ?		acyl anchorage androgen biomarker coa consequences databases dependence etoposide forced hormone lapatinib mcf mediator monitored nude public qnbc quadruple referred simultaneous skbr3 steroid stimulatory synthetase tamoxifen tnbc triacsin utilized	a4 abstract add2 adducin binder chimeric coordination cpsf160 cstf depletion dses evidences exclude excluded ftd hek293 hypothesize ltd ltp minigenes participates pas polya polyadenylation substitution sv40 synapse tdp tdp43
Tagcloud (Difference) ?		acyl anchorage androgen biomarker coa consequences databases dependence etoposide forced hormone lapatinib mcf mediator monitored nude public qnbc quadruple referred simultaneous skbr3 steroid stimulatory synthetase tamoxifen tnbc triacsin utilized	a4 abstract add2 adducin binder chimeric coordination cpsf160 cstf depletion dses evidences exclude excluded ftd hek293 hypothesize ltd ltp minigenes participates pas polya polyadenylation substitution sv40 synapse tdp tdp43
Tagcloud (Intersection) ?