ACSL4 and DSE

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ACSL4	DSE
Name		acyl-CoA synthetase long chain family member 4	dermatan sulfate epimerase
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Plasma Membrane Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Ligase Activity Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Palmitoyl-CoA Ligase Activity	Isomerase Activity Metal Ion Binding Chondroitin-glucuronate 5-epimerase Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Lipid Biosynthetic Process Neuron Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Insulin Secretion Negative Regulation Of Prostaglandin Secretion Long-chain Fatty-acyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Embryonic Process Involved In Female Pregnancy Fatty Acid Derivative Biosynthetic Process	Heparan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Chondroitin Sulfate Proteoglycan Metabolic Process Dermatan Sulfate Proteoglycan Metabolic Process
Pathways		Intracellular metabolism of fatty acids regulates insulin secretion Synthesis of very long-chain fatty acyl-CoAs	DS-GAG biosynthesis
Drugs		Icosapent Troglitazone Rosiglitazone	None
Diseases		Non-syndromic X-linked mental retardation	None
GWAS		Mean platelet volume ( 32888494 )	Fast beta electroencephalogram ( 28040410 ) Height ( 28552196 ) Heschl's gyrus morphology ( 25130324 ) Hip circumference adjusted for BMI ( 34021172 ) Mean platelet volume ( 32888494 ) Platelet count ( 32888494 ) Refractive error ( 32231278 ) Systemic lupus erythematosus ( 33272962 33536424 )
Interacting Genes		7 interacting genes: APP CDK1 DSE HTATIP2 PRKCB UBR5 YWHAQ	2 interacting genes: ACSL4 INTS11
Entrez ID		2182	29940
HPRD ID		02152	05807
Ensembl ID		ENSG00000068366	ENSG00000111817
Uniprot IDs		O60488 Q8TAF6	A0A2R8YE23 A0A2U3TZJ0 B3KY37 B7Z1T3 B7Z765 Q9UL01
PDB IDs		Not available	6HZN
GO Terms Enriched among Interactors		Positive Regulation Of Protein Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Protein Transport Positive Regulation Of Protein Localization Mitotic Nuclear Membrane Disassembly Membrane Disassembly Nuclear Membrane Disassembly Regulation Of Protein Localization To Nucleus Regulation Of Establishment Of Protein Localization Chromatin Remodeling Response To Copper Ion Positive Regulation Of Protein Import Into Nucleus Regulation Of Transport Chromatin Organization Protein Metabolic Process Positive Regulation Of Transport Nuclear Membrane Organization Intracellular Signal Transduction Regulation Of Protein Localization Protein Phosphorylation Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Pronuclear Fusion Phosphorylation Protein Serine/threonine Kinase Activity Positive Regulation Of Intracellular Protein Transport Acetylcholine Receptor Activator Activity Lipoprotein Particle Chromatin Binding Positive Regulation Of Protein Import Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Positive Regulation Of Protein Localization To Nucleus Histone H3T6 Kinase Activity Chondroitin-glucuronate 5-epimerase Activity Heterochromatin Boundary Formation PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium	Negative Regulation Of Prostaglandin Secretion Long-chain Fatty-acyl-CoA Biosynthetic Process Negative Regulation Of Icosanoid Secretion Very Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid-CoA Ligase Activity Embryonic Process Involved In Female Pregnancy Alpha-linolenic Acid Metabolic Process Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Arachidonate-CoA Ligase Activity Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Fatty Acid Transport Palmitoyl-CoA Ligase Activity SnRNA 3'-end Processing Integrator Complex INTAC Complex RNA Polymerase II Transcription Initiation Surveillance Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process Long-chain Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Transport Regulation Of Fatty Acid Transport Unsaturated Fatty Acid Biosynthetic Process SnRNA Processing Nuclear RNA Surveillance RNA Surveillance RNA Endonuclease Activity Transcription Elongation By RNA Polymerase II Fatty Acid Derivative Biosynthetic Process SnRNA Metabolic Process DNA-templated Transcription Elongation Peroxisomal Membrane Fatty Acid Derivative Metabolic Process Unsaturated Fatty Acid Metabolic Process Lipid Droplet Long-chain Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Positive Regulation Of Insulin Secretion RNA 3'-end Processing Regulation Of Transcription Elongation By RNA Polymerase II Sulfur Compound Biosynthetic Process Regulation Of DNA-templated Transcription Elongation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Fatty Acid Biosynthetic Process Ligase Activity Blood Microparticle Peroxisome Olefinic Compound Metabolic Process Regulation Of Lipid Transport