ACSL4

Name	acyl-CoA synthetase long chain family member 4
Structure	No pdb structure
Interactors	7 interactors: APP CDK1 DSE HTATIP2 PRKCB UBR5 YWHAQ
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Plasma Membrane Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Extracellular Exosome
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Ligase Activity Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Palmitoyl-CoA Ligase Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Lipid Biosynthetic Process Neuron Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Insulin Secretion Negative Regulation Of Prostaglandin Secretion Long-chain Fatty-acyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Embryonic Process Involved In Female Pregnancy Fatty Acid Derivative Biosynthetic Process
Pathways	Intracellular metabolism of fatty acids regulates insulin secretion Synthesis of very long-chain fatty acyl-CoAs
Drugs	Icosapent Troglitazone Rosiglitazone
Diseases	Non-syndromic X-linked mental retardation
GWAS	Mean platelet volume ( 32888494 )
Entrez ID	2182
HPRD ID	02152
Ensembl ID	ENSG00000068366
Uniprot IDs	O60488 Q8TAF6
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Positive Regulation Of Protein Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Protein Transport Positive Regulation Of Protein Localization Mitotic Nuclear Membrane Disassembly Membrane Disassembly Nuclear Membrane Disassembly Regulation Of Protein Localization To Nucleus Regulation Of Establishment Of Protein Localization Chromatin Remodeling Response To Copper Ion Positive Regulation Of Protein Import Into Nucleus Regulation Of Transport Chromatin Organization Protein Metabolic Process Positive Regulation Of Transport Nuclear Membrane Organization Intracellular Signal Transduction Regulation Of Protein Localization Protein Phosphorylation Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Pronuclear Fusion Phosphorylation Protein Serine/threonine Kinase Activity Positive Regulation Of Intracellular Protein Transport Acetylcholine Receptor Activator Activity Lipoprotein Particle Chromatin Binding Positive Regulation Of Protein Import Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Positive Regulation Of Protein Localization To Nucleus Histone H3T6 Kinase Activity Chondroitin-glucuronate 5-epimerase Activity Heterochromatin Boundary Formation PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium