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CYP39A1 and GLUL
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
CYP39A1
GLUL
Gene Name
cytochrome P450, family 39, subfamily A, polypeptide 1
glutamate-ammonia ligase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Intracellular Membrane-bounded Organelle
Nucleus
Cytoplasm
Mitochondrion
Rough Endoplasmic Reticulum
Cytosol
Perikaryon
Protein Complex
Axon Terminus
Extracellular Vesicular Exosome
Glial Cell Projection
Molecular Function
Iron Ion Binding
Steroid 7-alpha-hydroxylase Activity
Oxysterol 7-alpha-hydroxylase Activity
Heme Binding
24-hydroxycholesterol 7alpha-hydroxylase Activity
Magnesium Ion Binding
Glutamate Decarboxylase Activity
Glutamate-ammonia Ligase Activity
ATP Binding
Glutamate Binding
Manganese Ion Binding
Identical Protein Binding
Dynein Light Chain Binding
Biological Process
Bile Acid Biosynthetic Process
Cholesterol Catabolic Process
Xenobiotic Metabolic Process
Digestion
Bile Acid Metabolic Process
Sterol Metabolic Process
Bile Acid Catabolic Process
Small Molecule Metabolic Process
Oxidation-reduction Process
Neurotransmitter Uptake
Glutamate Catabolic Process
Glutamine Biosynthetic Process
Synaptic Transmission
Cell Proliferation
Cellular Amino Acid Biosynthetic Process
Cellular Response To Starvation
Response To Glucose
Positive Regulation Of Insulin Secretion
Cellular Nitrogen Compound Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Epithelial Cell Proliferation
Protein Homooligomerization
Positive Regulation Of Synaptic Transmission, Glutamatergic
Pathways
Bile acid and bile salt metabolism
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
Metabolism of lipids and lipoproteins
Metabolic disorders of biological oxidation enzymes
Phase 1 - Functionalization of compounds
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Cytochrome P450 - arranged by substrate type
Endogenous sterols
Biological oxidations
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Defective FMO3 causes Trimethylaminuria (TMAU)
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Defective CYP1B1 causes Glaucoma
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
Defective MAOA causes Brunner syndrome (BRUNS)
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Astrocytic Glutamate-Glutamine Uptake And Metabolism
Neurotransmitter uptake and Metabolism In Glial Cells
Amino acid synthesis and interconversion (transamination)
Metabolism of amino acids and derivatives
Transmission across Chemical Synapses
Drugs
L-Glutamine
L-Glutamic Acid
Diseases
GWAS
Protein-Protein Interactions
4 interactors:
GLUL
ORM2
SERINC1
SMYD3
18 interactors:
CASP8AP2
CYP39A1
DYNLL1
HIPK1
HIPK3
HTR2A
ND5
NFKB1
NUDT18
PIAS1
PIAS2
PIAS3
PLEKHF2
PPARD
RABEPK
RBBP6
SKIL
UBE2I
Entrez ID
51302
2752
HPRD ID
07067
00701
Ensembl ID
ENSG00000146233
ENSG00000135821
Uniprot IDs
B7Z786
Q9NYL5
A8YXX4
P15104
PDB IDs
2OJW
2QC8
Enriched GO Terms of Interacting Partners
?
Protein Sumoylation
Transcription, DNA-templated
RNA Biosynthetic Process
Cell Death
Death
Regulation Of Signal Transduction
Nucleobase-containing Compound Metabolic Process
Regulation Of Signaling
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-lysine Modification
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Protein Sumoylation
Apoptotic Process
Regulation Of Transcription, DNA-templated
Gene Expression
MRNA Transcription
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Programmed Cell Death
Protein Modification By Small Protein Conjugation
Regulation Of RNA Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of Protein Sumoylation
Apoptotic Signaling Pathway
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Signal Transduction
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Cell Differentiation
Intracellular Receptor Signaling Pathway
Androgen Receptor Signaling Pathway
Regulation Of Apoptotic Process
Cellular Metabolic Process
Peptidyl-amino Acid Modification
Response To Mechanical Stimulus
Regulation Of Cell Death
Regulation Of Cell Differentiation
Positive Regulation Of Fat Cell Differentiation
DGDP Catabolic Process
DADP Catabolic Process
Negative Regulation Of Interleukin-12 Biosynthetic Process
Tagcloud
?
bell
bgh
bio
blots
bromo
cnp
deoxyuridine
dlgap2
dor
fibrillary
gfap
gh
glutamine
grin2a
gs
haemoglobin
hbb
igf1
igf1r
inactivity
ionotropic
modestly
phosphodiesterase
postsynaptic
robustly
sapap2
synapse
synthetase
tg
Tagcloud (Difference)
?
bell
bgh
bio
blots
bromo
cnp
deoxyuridine
dlgap2
dor
fibrillary
gfap
gh
glutamine
grin2a
gs
haemoglobin
hbb
igf1
igf1r
inactivity
ionotropic
modestly
phosphodiesterase
postsynaptic
robustly
sapap2
synapse
synthetase
tg
Tagcloud (Intersection)
?