CYP39A1 and ORM2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CYP39A1	ORM2
Description		cytochrome P450 family 39 subfamily A member 1	orosomucoid 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Steroid 7-alpha-hydroxylase Activity Steroid Hydroxylase Activity Oxysterol 7-alpha-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding 24S-hydroxycholesterol 7-alpha-hydroxylase Activity Metal Ion Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Bile Acid Biosynthetic Process Cholesterol Catabolic Process Digestion Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Cholesterol Homeostasis	Regulation Of Immune System Process Acute-phase Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production
Pathways		Synthesis of bile acids and bile salts via 24-hydroxycholesterol Endogenous sterols	Platelet degranulation Neutrophil degranulation
Drugs			Disopyramide Lidocaine Imipramine Chlorpromazine Thalidomide Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Normal facial asymmetry (deformation magnitude) ( 30631343)
Interacting Genes		4 interacting genes: GLUL ORM2 SERINC1 SMYD3	3 interacting genes: CYP39A1 PRDX6 STK3
Entrez ID		51302	5005
HPRD ID		07067	00725
Ensembl ID		ENSG00000146233	ENSG00000228278
Uniprot IDs		A0A087WTD2 B7Z786 Q9NYL5	P19652
PDB IDs			3APU 3APV 3APW 3APX 7OUB
Enriched GO Terms of Interacting Partners?		Glutamine Synthetase Activity Intracellular Ammonium Homeostasis Glutamine Biosynthetic Process Ammonium Homeostasis L-glutamate Catabolic Process Membrane Biogenesis RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Histone H4 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Regulation Of Protein Localization To Nucleolus Acetyltransferase Activator Activity	Steroid 7-alpha-hydroxylase Activity Oxysterol 7-alpha-hydroxylase Activity 24S-hydroxycholesterol 7-alpha-hydroxylase Activity Primitive Hemopoiesis Neural Tube Formation Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development 1-acylglycerophosphocholine O-acyltransferase Activity Calcium-independent Phospholipase A2 Activity Peroxiredoxin Activity Lipid Catabolic Process Cholesterol Catabolic Process BBSome
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